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1.
Metabolites ; 12(6)2022 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-35736464

RESUMO

Lesniowski-Crohn's disease (CD) is a type of chronic inflammatory bowel disease (IBD) of uncertain etiology. Initially, pharmacological management is undertaken; however, surgical intervention is necessary to improve life quality and relieve symptoms in most cases. Here changes are reported in blood metabolome that occurred three days after the ileo-colic region resection in the case of seven patients. Alterations are observed in levels of metabolites associated with multiple mitochondrial pathways, based on the Metabolite Set Enrichment Analysis, reflecting a high energy demand in the post-operative period. As most of these metabolites are also essential nutrients supplied from foods, we believe that our results might contribute to the discussion on perioperative nutrition's role in enhanced recovery.

2.
Pol Przegl Chir ; 85(10): 569-75, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24310759

RESUMO

UNLABELLED: The abdominoperineal resection of the rectum is a classical operation performed in case of patients diagnosed with rectal cancer. The development of laparoscopic techniques in recent years, introduced yet another method of treatment, considering patients with rectal cancer- laparoscopic abdominoperineal resection of the rectum. The aim of the study was to present initial treatment results considering the above-mentioned patients. MATERIAL AND METHODS: The study group comprised 25 patients (16 male and 9 female) diagnosed with low-rectal cancer, subjected to surgery by means of the above-mentioned method. Mean patient age amounted to 66 years. Three (12%) patients required conversion to classical surgery (laparotomy), while one patient required reoperation, due to presacral vascular bleeding. Complications were observed in 10 (40%) patients. Average hospitalization was 7 days. In case of all patients the radial margin was negative, and mean number of removed lymph nodes amounted to 9.6. Mortality was not observed during the perioperative period. Due to the initial character of the study analysis (mean observation period in case of 68% of patients was shorter than 2 years), oncological results were not subject to evaluation. CONCLUSIONS: Laparoscopic abdominoperineal resections are considered as technically difficult operations, requiring significant experience of the operating team. However, they enable the patient to take advantage of the many assets of minimally invasive surgery, with comparable rates of postoperative complications.


Assuntos
Adenocarcinoma/cirurgia , Neoplasias Retais/cirurgia , Reto/cirurgia , Adenocarcinoma/secundário , Idoso , Conversão para Cirurgia Aberta , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Feminino , Humanos , Laparoscopia/métodos , Tempo de Internação , Excisão de Linfonodo , Metástase Linfática , Masculino , Pneumotórax Artificial , Estudos Prospectivos , Reoperação , Resultado do Tratamento
3.
Pol Przegl Chir ; 84(7): 352-7, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22935457

RESUMO

THE AIM OF THE STUDY: Was an evaluation of conversion causes and intraoperative difficulties in patients treated with laparoscopic surgery due to colorectal tumours on the basis of authors' own material. MATERIAL AND METHODS: in the period 2009-2012 160 patients were operated on because of large bowel cancer, 79 women and 81 men. Average age of patients was 66 years. The conversion was recognized as desuflation of peritoneal cavity, trocars removal and making laparotomy. RESULTS: The conversion was made in 22 cases (13,7%). More in men (16.1%) than in women. The conversion was made twice as likely in T3 and T4 tumors than in T1 and T2. CONCLUSIONS: The main cause of conversion in laparoscopic operations of colorectal cancer is local tumor progression.


Assuntos
Neoplasias Colorretais/patologia , Neoplasias Colorretais/cirurgia , Complicações Intraoperatórias/etiologia , Complicações Intraoperatórias/cirurgia , Laparoscopia/efeitos adversos , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Laparoscopia/métodos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Reoperação , Medição de Risco , Resultado do Tratamento
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