Association between raftlin and presepsin levels with periodontal healthy and disease conditions.

OBJECTIVE: The aim of this study was to examine the association between Raftlin and Presepsin levels in periodontal healthy/diseases, hypothesizing a change in their levels. Also, the study aimed to determine their potential role in diagnosing and predicting the prognosis of periodontal diseases. DESIGN: A cross-sectional study design was used, including 20 periodontally healthy individuals, 21 gingivitis patients, and 21 periodontitis patients. Clinical measurements and gingival crevicular fluid (GCF) sample collection were conducted, and the levels of Raftlin and Presepsin were analyzed. Statistical analysis was performed to evaluate the differences and correlations among the groups. RESULTS: Raftlin and Presepsin levels displayed significant variations among groups in both total amount (mean values for Raftlin in periodontitis, gingivitis, and healthy were 33.42, 17.45, 7.70 pg/30 s, respectively; for Presepsin, values were 3.98, 3.01, 1.92 pg/30 s, respectively) (p < 0.001) and concentration levels (pg/µl) (p = 0.007 for Raftlin, p = 0.026 for Presepsin). Particularly noteworthy were the concentration distinctions observed exclusively between the periodontitis and healthy groups. CONCLUSIONS: The present study offers preliminary insights into the presence and variations of raftlin and prepsepsin in the GCF across different periodontal conditions. While these findings hint at a potential role for these markers in periodontal disease, further research is essential to fully understand their diagnostic and prognostic capabilities.

Effect of peri-implant disease on oral health-related quality of life in geriatric patients.

OBJECTIVE: This study aimed to evaluate the effect of peri-implant disease on the quality of life in geriatric patients using implant-supported overdentures. BACKGROUND: Peri-implant disease and bone loss are two main complications of dental implant treatment that can impact the quality of life in the geriatric population. MATERIALS AND METHODS: This cross-sectional study included 109 geriatric individuals treated in the prosthodontics and periodontology departments. On clinical examination, periodontal pocket depth, gingival index (GI) and plaque index (PIn) were measured to determine peri-implant status. Marginal bone loss was measured by radiological examination, using ImageJ software. Moreover, the Oral Healthy Impact Profile-14 (OHIP-14) questionnaire was used to evaluate participants' perceived oral health-related quality of life. RESULTS: Peri-implantitis (PI) and peri-implant mucositis (PM) prevalence were 30% and 24%, respectively. Only 44% of patients had healthy implants. Although total OHIP-14 scores were higher in the PI group than in the healthy and PM groups, this difference was not statistically significant (P = .148). Total OHIP-14 score was significantly correlated with PIn and GI. CONCLUSIONS: Within the limitations of this study, it can be said that on quality of life in patients using implant-supported overdenture related to clinical parameters such as PIn and GI. Results also indicated that geriatric patients should take action to improve their oral health. Further longitudinal studies are needed to support our results and should include control groups that use conventional removable dentures.

The Effect of Periodontal and Peri-Implanter Health on IL-1 and TNF- Levels in Gingival Crevicular and Peri-Implanter Sulcus Fluid: a Cross-Sectional Study / El efecto de la salud periodontal y peri-implantar en niveles de IL-1ß y TNF-α en el fluido crevicular y sulcus peri-implantador: un estudio transversal

Abstract: It is stated that peri-implanter diseases have destructive effects similar to periodontal diseases. This study aims to compare IL-1β and TNF-α levels in healthy and diseased areas. Forty non-smokers systemically health individuals (40 implants/40 teeth) (age:38-67) were included in the study. In clinical and radiographic examinations; plaque index (PIn), gingival index (GI), periodontal pocket depth (PPD), clinical attachment level (CAL) and marginal bone loss (MBL) values were recorded. The gingival crevicular fluid (GCF) and peri-implanter sulcus fluids (PISF) of the patients were collected, and IL-1β and TNF-α levels were measured by ELISA in the samples. The collected data were analyzed with the help of SPSS v.22 package program. Sample PPD score showed a statistically significant difference between the diseased and healthy groups and also sample CAL showed statistically significant higher in Periodontitis(P) compared to periodontally heathy(H) and Gingivitis(G) (p>0.05). IL-1beta and TNF-α levels in GCF/PISF; In the P and Peri-implantitis (PI) group, it was found statistically significantly higher than the H, Healthy-Implant (HI), besides P showed higher levels compared to G (p<0.05). Within the limitations of our study, it can be said that IL-1β and TNF-α among inflammatory cytokines in GCF/PISF will increase in periodontal and peri-implanter diseases, it can also be said that this increase in cytokines may indicate that periodontal and peri-implanter diseases have similar immunological structure. Peri-implant mucositis without periodontitis history has similarity to peri-implantitis and periodontitis in terms of IL-1β and TNF-α levels in GCF/PISF.

Resumen: Se afirma que las enfermedades peri-implantarias tienen efectos destructivos similares a los de las enfermedades periodontales. Este estudio tiene como objetivo comparar los niveles de IL-1β y TNF-α en zonas sanas y enfermas. Cuarenta individuos no fumadores con salud sistémica (40 implantes/40 dientes) (edad:38-67) fueron incluidos en el estudio. En los exámenes clínicos y radiográficos se registraron los valores de índice de placa (PIn), índice gingival (GI), profundidad de la bolsa periodontal (PPD), nivel de fijación clínica (CAL) y pérdida de hueso marginal (MBL). Se recogieron los fluidos creviculares gingivales (GCF) y los fluidos del surco peri-implantario (PISF) de los pacientes, y se midieron los niveles de IL-1β y TNF-α mediante ELISA en las muestras. Los datos recogidos fueron analizados con la ayuda del programa de paquete SPSS v.22. La puntuación PPD de la muestra mostró una diferencia estadísticamente significativa entre los grupos enfermos y sanos y también la muestra CAL mostró estadísticamente significativa más alta en la Periodontitis (P) en comparación con la salud periodontal (H) y la Gingivitis (G) (p>0.05). Los niveles de IL-1beta y TNF-α en GCF/PISF. En el grupo de P y Peri-implantitis (PI), se encontró estadísticamente significativo más alto que el H, implante sano (HI), además P mostró niveles más altos en comparación con G (p<0.05). Dentro de las limitaciones de nuestro estudio, se puede decir que IL-1β y TNF-α entre las citoquinas inflamatorias en GCF/PISF aumentarán en las enfermedades periodontales y peri-implantarias. También se puede decir que este aumento de citoquinas puede indicar que las enfermedades periodontales y peri-implantarias tienen una estructura inmunológica similar. La mucositis peri-implantaria sin antecedentes de periodontitis tiene similitudes con la peri-implantitis y la periodontitis en cuanto a los niveles de IL-1β y TNF-α en la GCF/PISF.