RESUMO
Psoriasis in plaques is a chronic disease that requires systemic treatment in its moderate and severe forms. Because the need for treatment is generally prolonged, many medications indicated for its treatment cannot be used continuously and have to be replaced by other different drugs, but also with a limited use, both due to their possible side effects, their teratogenicity, the time of use and accumulated dose, among other reasons. The biological drugs have been designed for middle and long term control of the disease. Efalizumab is a drug that has been shown to be effective and safe in patients who have moderate-to-severe psoriasis. We present our results in a group of 50 patients, our special cases, the form in which we have treated the side effects due to Efalizumab and those due to the disease.
Assuntos
Anticorpos Monoclonais/uso terapêutico , Produtos Biológicos/uso terapêutico , Fármacos Dermatológicos/uso terapêutico , Psoríase/terapia , Adulto , Anticorpos Monoclonais/efeitos adversos , Anticorpos Monoclonais Humanizados , Produtos Biológicos/efeitos adversos , Fármacos Dermatológicos/efeitos adversos , Toxidermias/etiologia , Feminino , Febre/etiologia , Seguimentos , Cefaleia/etiologia , Hospitais Universitários , Humanos , Leucocitose/etiologia , Masculino , Pessoa de Meia-Idade , Gravidez , Complicações na Gravidez/terapia , Estudos Retrospectivos , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
Blue nevus rarely develops a malignant melanoma. The loss of the regular border and the development of satellite lesions are ominous clinical indicators of the malignant change. A case is presented in which both of these clinical features--irregular border and satellite lesions--were present, but no malignant change was observed histopathologically. To our knowledge, such a single nodule with satellite lesions mimicking malignant melanoma has not been described previously.
Assuntos
Melanoma/patologia , Nevo Azul/patologia , Neoplasias Cutâneas/patologia , Idoso , Diagnóstico Diferencial , Humanos , MasculinoRESUMO
Two unrelated patients, a woman aged 44 and a man aged 56, with a type I neurofibromatosis, showed comedo-like formations at the top of some neurofibromas. One of them was excised in each case and they were studied histopathologically. The comedo-like formation of the first case mimicked the epithelial component of a fibrofolliculoma, and that of the second case had the structure of a primary late microcomedo and showed also anagen hair differentiation in the form of a follicular bulb and papilla. Both events are considered to be the result of a stimulation phenomenon and to reflect the essential role of the stroma in many cutaneous epithelial hyperplasias, hamartomas and possibly in some neoplasms.
