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1.
Arch Esp Urol ; 61(4): 485-98, 2008 May.
Artigo em Espanhol | MEDLINE | ID: mdl-18592766

RESUMO

OBJECTIVES: To study paratesticular malignant fibrous histiocytomas (FHM) from the clinical, histological, immunohistochemical and histogenetic, point of view. METHODS: Through Medline and not index-linked search of international scientific literature we have found a total of 77 cases of paratesticular FHM that globally create diagnostic, terminological and therapeutic problems. RESULTS: We include the case number 78 of FHM of spermatic cord, that presents a few special characteristics (not described before) of cutaneous fistula and infiltration of an inguinal leiomyoma, with histological and immunohistochemical confirmation. We performed a conceptual review of this type of tumours, including the evaluation of contradictions and reclassifications that has undergone from its first description, which causes that they are underestimated and their real prevalence in international series is very variable: from 7 to 37% of paratesticular sarcomas. Also, the fact of their low incidence has determined the lack of protocols for diagnosis and treatment. CONCLUSIONS: Paratesticular tumours, although infrequent, have a high rate of malignancy. The FHM concept has varied throughout the last 15 years. Today, this term is synonymous of pleomorphic undifferentiated sarcoma and has been an exclusion diagnosis (Vimentin [+]/ CD 68 [+]--occasionally--without ultrastructural differences), reserving the inflammatory subtype for which they have an inflammatory and histiocytic component. The accomplishment of an intraoperatory biopsy is essential in this location, since it is even difficult to know preoperatively, if a lesion is benign or malignant. The differential diagnosis is only solved after microscopic and inmunohistochemical study. Leiomyoma next to this location (inguinal) could be diagnosed and confused with a nodule of the main FHM. Their immunophenotype allowed us to diagnose it not only as leiomyoma (myogenic markers were positive -non skeletal muscle-), but also to observe the infiltration by the FHM.


Assuntos
Neoplasias dos Genitais Masculinos/patologia , Histiocitoma/patologia , Canal Inguinal , Leiomioma/patologia , Neoplasias Primárias Múltiplas/patologia , Cordão Espermático , Idoso de 80 Anos ou mais , Neoplasias dos Genitais Masculinos/imunologia , Histiocitoma/imunologia , Humanos , Imunofenotipagem , Inflamação/patologia , Masculino , Invasividade Neoplásica , Neoplasias Primárias Múltiplas/imunologia
2.
Acta Cytol ; 48(2): 234-8, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15085759

RESUMO

BACKGROUND: Lymphoepithelioid cell lymphoma (LCL) is a rare morphologic variant of peripheral T-cell lymphoma. Although their histopathologic and immunohistochemical findings are well known, the cytopathologic features have not been well documented. This report describes the fine needle aspiration cytology (FNAC) findings of a case of LCL. CASE: A 75-year-old woman presented with cervical, supraclavicular, axillary and mediastinal lymphadenopathy. FNAC of a cervical lymph node was performed. The smears contained a polymorphous infiltrate formed by abundant histiocytes disposed singly or in clusters, small and medium-sized to large atypical lymphoid cells and reactive cells, including eosinophils and plasma cells. Isolated capillary-sized vessels also were observed. Histopathologic and immunohistochemical examination confirmed the diagnosis of Lennert's lymphoma. CONCLUSION: Although histopathologic and immunohistochemical studies were required for a definitive diagnosis, the findings of FNAC in this case appeared distinctive and suggested the possibility of LCL.


Assuntos
Linfonodos/patologia , Doenças Linfáticas/patologia , Linfoma de Células T/patologia , Idoso , Antígenos de Superfície/metabolismo , Biomarcadores Tumorais/metabolismo , Biópsia por Agulha Fina , Tamanho Celular/fisiologia , Epitopos de Linfócito T/imunologia , Feminino , Humanos , Doenças Linfáticas/etiologia , Linfócitos/imunologia , Linfócitos/patologia
3.
Rev. esp. patol ; 37(1): 91-98, ene. 2004. ilus, tab
Artigo em Es | IBECS | ID: ibc-30713

RESUMO

Se presenta un caso de proliferación nodular y difusa fibrosa de la túnica vaginal testicular en un varón de 28 años de edad con 3 años de evolución. La exploración física mostró una masa escrotal firme en el testículo izquierdo. En el acto quirúrgico se observó una cubierta endurecida, multinodular, en la túnica vaginal de dicho testículo. La impresión intraoperatoria fue la de un tumor de músculo liso benigno y la lesión fue extirpada. Macroscópicamente correspondía a una masa firme, multinodular y difusa de la túnica vaginal. Microscópicamente se correspondía con un pseudotumor fibroso formado por tejido conectivo denso hialinizado y fibroblastos con un pequeño número de agregados linfoides en la perifería de la lesión (AU)


Assuntos
Adulto , Masculino , Humanos , Testículo/citologia , Testículo/patologia , Fibrose Cística/diagnóstico , Fibrose Cística/patologia , Fibroblastos/patologia , Calcinose/diagnóstico , Calcinose/patologia , Neoplasias Testiculares/diagnóstico , Neoplasias Testiculares/patologia , Microscopia/métodos , Microscopia/instrumentação , Neoplasias Testiculares/diagnóstico , Neoplasias Testiculares/patologia
4.
Arch Esp Urol ; 56(4): 428-30, 2003 May.
Artigo em Espanhol | MEDLINE | ID: mdl-12830617

RESUMO

OBJECTIVES: To report the case of a patient with the diagnosis of solid renal mass after ultrasound and confirmatory CT scan, whose final diagnosis was inflammatory pseudotumour, a rare benign tumour. METHODS: We describe the case, diagnostic difficulties and treatment because of the exceptional character of the case. RESULTS: A bibliographic review was necessary to achieve consensus acceptance of an etiologic relationship between tumour and previous renal trauma 15 years before. CONCLUSIONS: The hypothesis of renal pseudotumour should not be rejected in similar cases.


Assuntos
Carcinoma de Células Renais/diagnóstico , Granuloma de Células Plasmáticas/diagnóstico , Nefropatias/diagnóstico , Neoplasias Renais/diagnóstico , Rim/lesões , Acidentes por Quedas , Adulto , Diagnóstico Diferencial , Granuloma de Células Plasmáticas/diagnóstico por imagem , Granuloma de Células Plasmáticas/etiologia , Granuloma de Células Plasmáticas/cirurgia , Humanos , Nefropatias/diagnóstico por imagem , Nefropatias/etiologia , Nefropatias/cirurgia , Masculino , Nefrectomia , Tomografia Computadorizada por Raios X , Ultrassonografia
5.
Acta Cytol ; 47(3): 485-9, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-12789937

RESUMO

BACKGROUND: Neurothekeoma (NT) is a rare, benign neoplasm of soft parts with a distinctive histologic appearance. To our knowledge, the cytologic findings have not been described before. We present a case of NT with the cytologic features on fine needle aspiration cytology (FNAC). CASE: A 54-year-old female presented with a circumscribed nodule in the left breast. The lesion was evaluated by FNAC. The smears showed an abundant, metachromatic, myxoid matrix with fusiform and epithelioid cells, some binucleated or multinucleated, loose or in groups and sometimes forming concentric whorls. The lesion was removed, and the diagnosis of NT was made after histopathologic study. CONCLUSION: NT is an extremely rare neoplasm in the mammary region. Fusiform and epithelioid cells arranged in concentric whorls in a myxoid tumor of soft tissue are a distinctive characteristic of this neoplasm and can suggest the diagnosis.


Assuntos
Biópsia por Agulha/métodos , Mama/patologia , Neurotecoma/patologia , Neoplasias de Tecidos Moles/patologia , Biomarcadores Tumorais/análise , Mama/cirurgia , Células Epitelioides/patologia , Feminino , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Neurotecoma/química , Neurotecoma/cirurgia , Neoplasias de Tecidos Moles/química , Neoplasias de Tecidos Moles/cirurgia , Vimentina/análise
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