Assuntos
Infecções por Helicobacter/complicações , Helicobacter pylori , Linfoma de Zona Marginal Tipo Células B/complicações , Neoplasias Cutâneas/complicações , Adulto , Amoxicilina/administração & dosagem , Claritromicina/administração & dosagem , Diagnóstico Diferencial , Quimioterapia Combinada , Feminino , Infecções por Helicobacter/diagnóstico , Infecções por Helicobacter/tratamento farmacológico , Humanos , Linfoma de Zona Marginal Tipo Células B/diagnóstico , Linfoma de Zona Marginal Tipo Células B/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Omeprazol/administração & dosagem , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/tratamento farmacológicoRESUMO
Topical tretinoin is used in the treatment of acne and other dermatoses. The most common side-effects are itching, dryness and reddening of the skin. We report an additional cutaneous reaction, which occurred in patients using topical tretinoin. Pyogenic granulomas developed in two patients with acne and in one with dermatofibroma following application of tretinoin. The granulomas grew on the lesions after 2-3 weeks of therapy initiation. All patients were men and the granulomas developed in their trunk. The lesions resolved when topical tretinoin was ceased. Although the number of patients reported is too small to estimate the true incidence of this reaction, it is likely that dermatologists will encounter similar reactions in patients treated with topical tretinoin for acne or other reasons.
Assuntos
Granuloma Piogênico/induzido quimicamente , Granuloma Piogênico/patologia , Dermatopatias/induzido quimicamente , Dermatopatias/patologia , Tretinoína/efeitos adversos , Acne Vulgar/tratamento farmacológico , Administração Tópica , Adolescente , Adulto , Biópsia por Agulha , Humanos , Imuno-Histoquímica , Ceratolíticos/efeitos adversos , Ceratolíticos/uso terapêutico , Masculino , Prognóstico , Medição de Risco , Estudos de Amostragem , Índice de Gravidade de Doença , Tretinoína/uso terapêuticoRESUMO
INTRODUCTION: Perforating necrobiosis lipoidica is a rare clinical form of necrobiosis lipoidica and is almost always associated with diabetes. Necrotized tissue is usually eliminated via transfollicular perforations. CASE REPORT: We report two cases of perforating necrobiosis lipoidica associated with type II diabetes mellitus. The characteristic clinical feature was the presence of keratotic plugs around the periphery of the lesions. Transfollicular perforation predominated in the first case. The second also presented epidermal perforation. DISCUSSION: There have been only 6 cases of perforating necrobiosis lipoidica in the literature. To our knowledge, this is the first case report of transepidermal elimination. We confirmed the constant association between this perforation type and diabetes mellitus.