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1.
Nanotechnology ; 35(9)2023 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-38035378

RESUMO

The morphology of numerous nanocolumnar thin films deposited by the magnetron sputtering technique at oblique geometries and at relatively low temperatures has been analyzed for materials as different as Au, Pt, Ti, Cr, TiO2, Al, HfN, Mo, V, WO3and W. Despite similar deposition conditions, two characteristic nanostructures have been identified depending on the material: a first one defined by highly tilted and symmetric nanocolumnar structures with a relatively high film density, and a second one characterized by rather vertical and asymmetric nanocolumns, with a much lower film density. With the help of a model, the two characteristic nanostructures have been linked to different growth dynamics and, specifically, to different surface relaxation mechanisms upon the incorporation of gaseous species with kinetic energies above the surface binding energy. Moreover, in the case of Ti, a smooth structural transition between the two types of growths has been found when varying the value of the power used to maintain the plasma discharge. Based on these results, the existence of different surface relaxation mechanisms is proposed, which quantitatively explains numerous experimental results under the same conceptual framework.

2.
Rev. int. med. cienc. act. fis. deporte ; 23(91): 321-342, jul. 2023. tab
Artigo em Inglês | IBECS | ID: ibc-226933

RESUMO

El presente estudio tuvo como objetivo evaluar el impacto de una unidad didáctica de Educación Física (EF) sobre la satisfacción en las clases de EF, la satisfacción de las necesidades psicológicas básicas, la motivación, el clima social escolar y el rendimiento cognitivo. Se utilizó un diseño cuasi-experimental con grupo control para una muestra total de 120 estudiantes de Educación Secundaria (M = 13,48; DT = 1,36) a los que se les administró un cuestionario para analizar las variables de estudio. Se aplicó la unidad didáctica basada en la hibridación de la gamificación y el aprendizaje cooperativo (GF + CL) durante 8 sesiones. El programa mostró mejoras en el índice de mediadores psicológicos, la función ejecutiva de la planificación, la satisfacción de los alumnos de educación física y el clima social escolar, lo que podría ser adecuado para mejorar el rendimiento de los profesores de educación física en los centros educativos. (AU)


The present study aimed to assess the impact of a Physical Education (PE) teaching unit on PE satisfaction classes, basic psychological needs satisfaction, motivation, school social climate and cognitive performance. A quasi-experimental design with a control group was used for a total sample of 120 students of Secondary Education (M = 13,48; SD = 1,36) to whom a questionnaire was administered to analyse the study variables. The teaching unit based on the hybridization of gamification and Cooperative Learning (GF + CL) was applied for 8 sessions. The programme showed improvements in the psychological mediators index, executive function of planning, the PE students satisfaction and the school social climate, which would make it suitable for the improvement in the performance of PE teachers in educational centres. (AU)


Assuntos
Humanos , Masculino , Feminino , Adolescente , Educação Física e Treinamento/tendências , Satisfação Pessoal , Inquéritos e Questionários , Ensino Fundamental e Médio , Espanha
3.
J Stroke Cerebrovasc Dis ; 31(2): 106259, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34923436

RESUMO

BACKGROUND: Atrial fibrillation has been associated with higher morbidity and mortality rates in acute ischemic stroke patients (AIS). However, there is scarce information regarding the clinical outcomes and strokes' characteristics among AIS patients with other type of arrhythmias. OBJECTIVE: Our study aims to analyze the hospital mortality rate, stroke characteristics, and clinical and demographical data of patients with any post-stroke arrhythmia. METHODS: Retrospective cohort study of AIS patients with 24h-Holter monitoring during hospital admission recruited between 2015-2020, outcomes were measured using the modified Rankin scale. RESULTS: 597 patients (61.13±13.61 years; 352 men) were included. Arrhythmias were diagnosed in 33 (5.5%), with atrial fibrillation as the most common finding (82%). Age was related to a higher rate of arrhythmia (P = 0.014). A larger prevalence of cardioembolic strokes (69.7% vs 16.6%, P < 0.05) and AIS in the middle cerebral artery's vascular territory (78.8% vs 58.7%, P < 0.05) were found amongst patients with an arrhythmia. No significant association was found between NIHSS at admission with neither incidence of arrhythmia nor mortality. Within the arrhythmia group, three in-hospital deaths were reported: one AF, one ventricular arrhythmia and one second-degree atrioventricular block. In a logistic regression analysis, patients with any kind of arrhythmia had a higher mortality rate (9.1% vs 1.2%, P = 0.011; OR 6.766, 95% CI 1.552 - 29.500). CONCLUSION: Arrhythmia detection after an AIS was associated with increased in-hospital mortality. Risk factors related to arrhythmia detection were a higher mean age, cardioembolic strokes and AIS affecting the middle cerebral artery.


Assuntos
Arritmias Cardíacas , Mortalidade Hospitalar , AVC Isquêmico , Idoso , Arritmias Cardíacas/diagnóstico , Arritmias Cardíacas/epidemiologia , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/epidemiologia , Feminino , Mortalidade Hospitalar/tendências , Humanos , AVC Isquêmico/mortalidade , AVC Isquêmico/terapia , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco
4.
Acta Ortop Mex ; 35(3): 286-289, 2021.
Artigo em Espanhol | MEDLINE | ID: mdl-34921540

RESUMO

Bone metastases from a primary cancer of any part of the body are the most common form of malignant bone tumor constituting approximately 70% of them. The proximal femur being the most common extra-vertebral location for its location; 10% of patients have some pathological fracture, which is a serious complication. Currently the objectives of the treatment of a pathological fracture are: resection with adequate oncological margins, that the patient survives the surgical intervention, maintain the functionality, that the placed implant has a longer life time than the patient. The use of non-conventional hip prostheses is an excellent treatment option fulfilling the 4 established objectives, therefore this case is presented in which a right bipolar hip hemiarthroplasty is performed with a non-conventional prosthesis where it was treated with a described complication and the surgery of resolution.


Las metástasis óseas de un cáncer primario de cualquier parte del cuerpo son la forma más común de tumor óseo maligno constituyendo aproximadamente 70% de ellos. Siendo el fémur proximal la localización extravertebral más común para su localización; 10% de los pacientes presentan alguna fractura patológica, lo que es una grave complicación. En la actualidad, los objetivos del tratamiento de una fractura patológica son: resección con márgenes oncológicos adecuados, que el paciente sobreviva la intervención quirúrgica, mantener la funcionalidad, que el implante colocado tenga un tiempo de vida más largo que el del paciente. El uso de prótesis de cadera no convencionales es una excelente opción de tratamiento cumpliendo los cuatro objetivos establecidos, por ello se presenta este caso en el que se realiza una hemiartroplastía de cadera derecha bipolar con una prótesis no convencional donde se cursa con una complicación y se realiza la cirugía de resolución.


Assuntos
Neoplasias , Próteses e Implantes , Humanos
5.
Rehabilitación (Madr., Ed. impr.) ; 55(4): 266-272, oct. - dic. 2021. tab
Artigo em Espanhol | IBECS | ID: ibc-227781

RESUMO

Objetivo Describir nuestra experiencia con un protocolo basado en el uso de sevoflurano para la sedación y analgesia durante la infiltración de toxina botulínica tipo A (BoNT-A), en niños con parálisis cerebral (PC), especialmente en términos de seguridad y eficacia. Material y métodos Estudio observacional retrospectivo de pacientes con PC a los que se realizó infiltración con BoNT-A bajo sedación con sevoflurano desde noviembre de 2012 hasta diciembre de 2019. Se revisaron las características demográficas, las características clínicas y funcionales, la efectividad de la sedación, los eventos adversos (EA) y la satisfacción del profesional. Resultados Se realizaron 387 sedaciones en 74 pacientes diagnosticados de PC. La sedación efectiva se logró en el 100% de los procedimientos, facilitando la colaboración durante la infiltración y la satisfacción del profesional. Se notificaron EA en el 6,02% de los procedimientos, siendo los más frecuentes las náuseas y los vómitos (3,88%) y la hipoxemia transitoria (2,07%). No se informaron EA graves. No se encontró asociación entre la incidencia de EA y las variables clínicas, funcionales o el riesgo antes de la anestesia. Conclusiones La sedación con sevoflurano muestra resultados prometedores en términos de seguridad y efectividad para el manejo de la agitación y el dolor durante la infiltración de BoNT-A en nuestra práctica clínica diaria. Además, puede facilitar la infiltración, permitir la exploración bajo sedación e infiltración multinivel con buena tolerancia (AU)


Objective This study aimed to describe our experience with a protocol based on sevoflurane sedation to control pain and agitation during botulinum toxin-A (BoNT-A) infiltration in children with cerebral palsy (CP), especially in terms of safety and efficacy. Material and methods We conducted a retrospective observational study of patients diagnosed with CP who underwent BoNT-A infiltration with sevoflurane sedation from November 2012 to December 2019. Demographic, clinical and functional characteristics, the effectiveness of sedation, adverse events (AE) and professional satisfaction were reviewed. Results A total of 387 sedations were successfully performed in 74 patients. Effective sedation was achieved in 100% of procedures, facilitating collaboration during infiltration and improving professional satisfaction. AE were reported in 6.02% of the procedures, the most frequent being nausea and vomiting (3.88%) and transient hypoxemia (2.07%). There were no severe AE. No association was found between the incidence of AE and the clinical and functional variables or risk before anaesthesia. Conclusion Sevoflurane sedation shows promising results in terms of safety and effectiveness for the management of agitation and pain during BoNT-A infiltration in our daily clinical practice. In addition, it can facilitate infiltration, allowing examination under sedation and multilevel infiltration with good tolerance (AU)


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Toxinas Botulínicas Tipo A/uso terapêutico , Paralisia Cerebral/tratamento farmacológico , Sevoflurano/uso terapêutico , Anestesia/métodos , Estudos Retrospectivos , Protocolos Clínicos
6.
Acta ortop. mex ; 35(3): 286-289, may.-jun. 2021. graf
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1374186

RESUMO

Resumen: Las metástasis óseas de un cáncer primario de cualquier parte del cuerpo son la forma más común de tumor óseo maligno constituyendo aproximadamente 70% de ellos. Siendo el fémur proximal la localización extravertebral más común para su localización; 10% de los pacientes presentan alguna fractura patológica, lo que es una grave complicación. En la actualidad, los objetivos del tratamiento de una fractura patológica son: resección con márgenes oncológicos adecuados, que el paciente sobreviva la intervención quirúrgica, mantener la funcionalidad, que el implante colocado tenga un tiempo de vida más largo que el del paciente. El uso de prótesis de cadera no convencionales es una excelente opción de tratamiento cumpliendo los cuatro objetivos establecidos, por ello se presenta este caso en el que se realiza una hemiartroplastía de cadera derecha bipolar con una prótesis no convencional donde se cursa con una complicación y se realiza la cirugía de resolución.


Abstract: Bone metastases from a primary cancer of any part of the body are the most common form of malignant bone tumor constituting approximately 70% of them. The proximal femur being the most common extra-vertebral location for its location; 10% of patients have some pathological fracture, which is a serious complication. Currently the objectives of the treatment of a pathological fracture are: resection with adequate oncological margins, that the patient survives the surgical intervention, maintain the functionality, that the placed implant has a longer life time than the patient. The use of non-conventional hip prostheses is an excellent treatment option fulfilling the 4 established objectives, therefore this case is presented in which a right bipolar hip hemiarthroplasty is performed with a non-conventional prosthesis where it was treated with a described complication and the surgery of resolution.

7.
Rehabilitacion (Madr) ; 55(4): 266-272, 2021.
Artigo em Espanhol | MEDLINE | ID: mdl-33468348

RESUMO

OBJECTIVE: This study aimed to describe our experience with a protocol based on sevoflurane sedation to control pain and agitation during botulinum toxin-A (BoNT-A) infiltration in children with cerebral palsy (CP), especially in terms of safety and efficacy. MATERIAL AND METHODS: We conducted a retrospective observational study of patients diagnosed with CP who underwent BoNT-A infiltration with sevoflurane sedation from November 2012 to December 2019. Demographic, clinical and functional characteristics, the effectiveness of sedation, adverse events (AE) and professional satisfaction were reviewed. RESULTS: A total of 387 sedations were successfully performed in 74 patients. Effective sedation was achieved in 100% of procedures, facilitating collaboration during infiltration and improving professional satisfaction. AE were reported in 6.02% of the procedures, the most frequent being nausea and vomiting (3.88%) and transient hypoxemia (2.07%). There were no severe AE. No association was found between the incidence of AE and the clinical and functional variables or risk before anaesthesia. CONCLUSION: Sevoflurane sedation shows promising results in terms of safety and effectiveness for the management of agitation and pain during BoNT-A infiltration in our daily clinical practice. In addition, it can facilitate infiltration, allowing examination under sedation and multilevel infiltration with good tolerance.


Assuntos
Anestesia , Toxinas Botulínicas Tipo A , Paralisia Cerebral , Fármacos Neuromusculares , Paralisia Cerebral/tratamento farmacológico , Criança , Humanos , Fármacos Neuromusculares/efeitos adversos , Estudos Observacionais como Assunto , Sevoflurano , Resultado do Tratamento
8.
Opt Express ; 28(23): 34812-34824, 2020 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-33182941

RESUMO

Rigorous knowledge of the optical fingerprint of droplets is imperative for the understanding of complex aerosol processes. Here, a Paul trap is operated to store single semi-volatile organic droplets in air. The droplets are illuminated with a green laser and the elastic scattering is collected on a CMOS camera. The setup provides excellent performance in terms of confinement and stability, allowing us to detect size changes of the order of few nanometres. The stability also allows us to measure vapour pressures with remarkable reproducibility. This approach supplies a robust method for the optical interrogation in the sub-micron range.

9.
Rev. chil. neuro-psiquiatr ; 58(3): 251-258, set. 2020.
Artigo em Espanhol | LILACS | ID: biblio-1138579

RESUMO

Resumen La Organización Mundial de la Salud (OMS) entiende salud no solo como la ausencia de enfermedad, sino que también considera el bienestar personal. El perdón es un concepto relacionado con el bienestar y se conceptualiza generalmente como la reducción de los pensamientos, sentimientos y conductas negativas, así como el aumento de las positivas, en torno a la persona particular involucrada o a la situación de transgresión. A nivel biológico, se ha vinculado con marcadores de menor estrés fisiológico, con áreas cerebrales relacionadas con la teoría de la mente, la empatía, la regulación emocional, y con neurotransmisores como la oxitocina y monoaminas. Se asocia además a mejores resultados en salud mental y física, principalmente a nivel cardiovascular. Existen numerosas intervenciones en perdón que han mostrado efectividad, siendo los modelos teóricos con más evidencia el modelo de Enright y el modelo REACH. Dado los potenciales beneficios y escasos riesgos, el estudio y abordaje del perdón en la práctica clínica se convierte en una posibilidad que los clínicos deberían considerar para eventualmente disminuir el malestar y aumentar el bienestar de los pacientes.


The World Health Organization (WHO) understands health not only as the absence of disease, but also considers personal well-being. Forgiveness is a concept related to well-being and is generally conceptualized as the reduction of negative thoughts, feelings and behaviors, as well as the increase of positive ones, around the particular person involved or the situation of transgression. At the biological level, it has been linked to markers of lower physiological stress, with brain areas related to the theory of mind, empathy, emotional regulation, and neurotransmitters such as oxytocin and monoamines. It is also associated with better results in mental and physical health, mainly at the cardiovascular level. There are numerous interventions in forgiveness that have shown effectiveness, being the theoretical models with more evidence the Enright model and the REACH model. Given the potential benefits and few risks, the study and approach of forgiveness in clinical practice becomes a possibility that clinicians should consider to eventually reduce discomfort and increase the well-being of patients.


Assuntos
Humanos , Qualidade de Vida , Saúde , Saúde Mental , Emoções , Empatia , Perdão , Pessoas
10.
Opt Lett ; 45(9): 2518-2521, 2020 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-32356805

RESUMO

In a single shot, we measure the full propagation path, including the evolution to pulse collapse, of a high power femtosecond laser pulse propagating in air. Our technique enables examination of the effect of parameters that fluctuate on a shot-to-shot basis, such as pulse energy, pulse duration, and air turbulence-induced refractive index perturbations. We find that even in lab air over relatively short propagation distances, turbulence plays a significant role in determining the location of pulse collapse.

11.
Rev. int. med. cienc. act. fis. deporte ; 20(77): 103-118, mar. 2020. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-194771

RESUMO

El objetivo fue determinar la capacidad de predicción de las creencias implícitas de la habilidad sobre las creencias de las causas del éxito en el deporte. La muestra estuvo compuesta por 444 deportistas de alto rendimiento (233 chicos y 211 chicas; M = 16,70; DT = 0,49). Estos deportistas cumplimentaron el Inventario de Percepción de las Creencias sobre las Causas del Éxito en el deporte y la Escala de Creencias Implícitas sobre la Habilidad. Los resultados reflejaron que las creencias de habilidad incremental predicen el esfuerzo, mientras que las creencias de habilidad como entidad predicen la capacidad y el engaño como causas del éxito en balonmano


The main of this study was to determine the prediction of ability implicit beliefs of sport success causes in sport. The sample was comprised of 444 youth high performance players (233 boys and 211 girls; M = 16,70; SD = 0,49). These players completed the Spanish version of the Beliefs about the Causes of Success in Sport Questionnaire and the Conceptions of the Nature of Athletic Ability Questionnaire-2. The results revealed that belief of incremental ability predict effort, while ability beliefs as an entity predict the capability and the deception as the causes of success in handball


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Destreza Motora/fisiologia , Sucesso Acadêmico , Motivação , Atletas/psicologia , Desempenho Atlético/fisiologia , Inquéritos e Questionários
12.
Rev. int. med. cienc. act. fis. deporte ; 19(75): 415-430, sept. 2019. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-187223

RESUMO

El objetivo de este estudio fue conocer las relaciones existentes entre la responsabilidad percibida por los estudiantes, los mediadores psicológicos, la motivación autodeterminada, deportividad, estilo de vida e intención de ser físicamente activo, proponiendo un modelo de predicción en consonancia con los postulados del modelo jerárquico de la motivación intrínseca y extrínseca. Participaron 128 estudiantes de Educación Física (68 chicos y 60 chicas) con edades comprendidas entre los 11 y los 15 años (M = 12,45; DT = 1,15). Se utilizó un diseño transversal. Se administraron los cuestionarios PSRQ, BPNES, CMEF, MSOS, IPAS y Test corto Krece Plus para medir las variables estudiadas. Los resultados mostraron que la responsabilidad percibida predijo positivamente la satisfacción de los mediadores psicológicos y estados de motivación autodeterminada. Como consecuencia, se explica una mayor importancia de la deportividad, de la intención de práctica futura y percepción del estilo de vida en los participantes


The aim of this study was to understand the relationships between the perceived responsibility by students, psychological mediators, self-determined motivation, sportsmanship, lifestyle and intention to be physically active, proposing a prediction model in line with the postulates of the hierarchical model of the intrinsic and extrinsic motivation. The participants were 128 students of Physical Education (68 boys and 60 girls) aged between 11 and 15 years (M = 12,45; SD = 1,15). A cross-sectional study was designed. The questionnaires PSRQ, BPNES, CMEF, MSOS, IPAS Krece Plus Short Test were used to measure the variables studied. The results showed that the perceived responsibility by students positively predicted the satisfaction of the psychological mediators and states of self-determined motivation. As a consequence of this, a greater importance of sportsmanship, intention of future practice and perception of lifestyle of the participating students is explained


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Educação Física e Treinamento/métodos , Estudantes de Ciências da Saúde/psicologia , Estilo de Vida , Atividade Motora/fisiologia , Educação Física e Treinamento/estatística & dados numéricos , Estudantes de Ciências da Saúde/estatística & dados numéricos
13.
Nanotechnology ; 30(47): 475603, 2019 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-31426050

RESUMO

We experimentally analyze different growth regimes of Ti thin films associated to the existence of kinetic energy-induced relaxation mechanisms in the material's network when operating at oblique geometries. For this purpose, we have deposited different films by evaporation and magnetron sputtering under similar geometrical arrangements and at low temperatures. With the help of a well-established growth model we have found three different growth regimes: (i) low energy deposition, exemplified by the evaporation technique, carried out by species with typical energies in the thermal range, where the morphology and density of the film can be explained by solely considering surface shadowing processes, (ii) magnetron sputtering under weak plasma conditions, where the film growth is mediated by surface shadowing mechanisms and kinetic-energy-induced relaxation processes, and (iii) magnetron sputtering under intense plasma conditions, where the film growth is highly influenced by the plasma, and whose morphology is defined by nanocolumns with similar tilt than evaporated films, but with much higher density. The existence of these three regimes explains the variety of morphologies of nanocolumnar Ti thin films grown at oblique angles under similar conditions in the literature.

14.
Rev. Hosp. Clin. Univ. Chile ; 30(1): 12-23, 2019. Ilus., Tab.
Artigo em Espanhol | LILACS | ID: biblio-1005566

RESUMO

Adult atopic dermatitis is a chronically recurring inflammatory dermatosis which presents in various forms. Some of these forms develop mostly in adults such as head and neck dermatitis and chronic hand eczema. Even though the diagnosis is clinical it frequently requires further investigations to exclude differential diagnosis. Once confirmed, it is crucial to classify its severity and exclude other comorbidities. Treatment includes general measures such as the use of emollients and soap substitutes which are applicable in all cases regardless of its severity. Other therapeutic options include topical corticosteroids, topical calcineurin inhibitors, phototherapy and immunosuppressants. Their use will depend on the degree of severity and specific characteristics of each individual. Newer biologics have proven to be a safe and effective alternative, and seem to be a promising option in cases of adult atopic dermatitis refractory to conventional treatments. (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Dermatite Atópica/diagnóstico , Dermatite Atópica/tratamento farmacológico , Dermatite Atópica/terapia
15.
Acta Crystallogr E Crystallogr Commun ; 74(Pt 4): 441-444, 2018 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-29765741

RESUMO

In the title compound, C7H6BNO2, the mean plane of the -B(OH)2 group is twisted by 21.28 (6)° relative to the cyano-phenyl ring mean plane. In the crystal, mol-ecules are linked by O-H⋯O and O-H⋯N hydrogen bonds, forming chains propagating along the [101] direction. Offset π-π and B⋯π stacking inter-actions link the chains, forming a three-dimensional network. Hirshfeld surface analysis shows that van der Waals inter-actions constitute a further major contribution to the inter-molecular inter-actions, with H⋯H contacts accounting for 25.8% of the surface.

16.
Acta Crystallogr C Struct Chem ; 74(Pt 4): 452-459, 2018 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-29620029

RESUMO

Boronic esters are useful building blocks for crystal engineering and the generation of supramolecular architectures, including macrocycles, cages and polymers (one-, two- and three-dimensional), with potential utility in diverse fields such as separation, storage and luminescent materials. The novel dinuclear cyanophenylboronic ester described herein, namely 4,4'-(2,4,8,10-tetraoxa-3,9-diboraspiro[5.5]undecane-3,9-diyl)dibenzonitrile, C19H16B2N2O4, was prepared by condensation of 4-cyanophenylboronic acid and pentaerythritol and fully characterized by elemental analysis, IR and NMR (1H and 11B) spectroscopy, single-crystal X-ray diffraction analysis and TG-DSC (thermogravimetry-differential scanning calorimetry) studies. In addition, the photophysical properties were examined in solution and in the solid state by UV-Vis and fluorescence spectroscopies. Density functional theory (DFT) calculations with ethanol as solvent reproduced reasonably well the HOMO (highest occupied molecular orbital) and LUMO (lowest unoccupied molecular orbital) of the title compound. Hirshfeld surface and fingerprint plot analyses are presented to illustrate the supramolecular connectivity in the solid state.

17.
J Thromb Haemost ; 16(5): 919-932, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29495105

RESUMO

Essentials Plg-RKT-/- female mice give birth, but no offspring of Plg-RKT-/- female mice survive to weaning. Causal mechanisms of potential lactational failure in Plg-RKT-/- mice are unknown. Plg-RKT regulates extracellular matrix remodeling, cell proliferation, apoptosis, fibrin surveillance. Plg-RKT is essential for lactogenesis and mammary lobuloalveolar development. SUMMARY: Background Lactational competence requires plasminogen, the zymogen of the serine protease, plasmin. Plg-RKT is a unique transmembrane plasminogen receptor that promotes plasminogen activation to plasmin on cell surfaces. Plg-RKT-/- mice are viable, but no offspring of Plg-RKT-/- female mice survive to weaning. Objectives We investigated potential lactational failure in Plg-RKT-/- mice and addressed causal mechanisms. Methods Fibrin accumulation, macrophage infiltration, processing of extracellular matrix components, effects of genetic deletion of fibrinogen, expression of fibrosis genes, and proliferation and apoptosis of epithelial cells were examined in lactating mammary glands of Plg-RKT-/- and Plg-RKT+/+ mice. Results Milk was not present in the stomachs of offspring of Plg-RKT-/- female mice and the pups were rescued by foster mothers. Although the mammary ductal tree developed normally in Plg-RKT-/- glands, lobuloalveolar development was blocked by a hypertrophic fibrotic stroma and infiltrating macrophages were present. A massive accumulation of fibrin was also present in Plg-RKT-/- alveoli and ducts. Although this accumulation was decreased when Plg-RKT-/- mice were made genetically heterozygous for fibrinogen, defects in lobuloalveolar development were not rescued by fibrinogen heterozygosity. Transcriptional profiling revealed that EGF was downregulated 12-fold in Plg-RKT-/- glands. Furthermore, proliferation of epithelial cells was not detectable. In addition, the pro-survival protein, Mcl-1, was markedly downregulated and apoptosis was observed in Plg-RKT-/- but not Plg-RKT+/+ glands. Conclusions Plg-RKT is essential for lactogenesis and functions to maintain the appropriate stromal extracellular matrix environment, regulate epithelial cell proliferation and apoptosis, and, by regulating fibrinolysis, preserve alveolar and ductal patency.


Assuntos
Fibrina/metabolismo , Lactação , Glândulas Mamárias Animais/metabolismo , Morfogênese , Receptores de Superfície Celular/deficiência , Animais , Apoptose , Proliferação de Células , Matriz Extracelular/metabolismo , Matriz Extracelular/patologia , Feminino , Fibrinogênio/genética , Fibrinogênio/metabolismo , Fibrose , Genótipo , Macrófagos/metabolismo , Macrófagos/patologia , Glândulas Mamárias Animais/crescimento & desenvolvimento , Glândulas Mamárias Animais/patologia , Camundongos da Linhagem 129 , Camundongos Endogâmicos C57BL , Camundongos Knockout , Fenótipo , Receptores de Superfície Celular/genética , Receptores de Superfície Celular/metabolismo
18.
Nanotechnology ; 28(46): 465605, 2017 11 17.
Artigo em Inglês | MEDLINE | ID: mdl-29063864

RESUMO

In this work we analyze a phenomenon that takes place when growing magnetron sputtered porous/compact multilayer systems by alternating the oblique angle and the classical configuration geometries. We show that the compact layers develop numerous fissures rooted in the porous structures of the film below, in a phenomenon that amplifies when increasing the number of stacked layers. We demonstrate that these fissures emerge during growth due to the high roughness of the porous layers and the coarsening of a discontinuous interfacial region. To minimize this phenomenon, we have grown thin interlayers between porous and compact films under the impingement of energetic plasma ions, responsible for smoothing out the interfaces and inhibiting the formation of structural fissures. This method has been tested in practical situations for compact TiO2/porous SiO2 multilayer systems, although it can be extrapolated to other materials and conditions.

19.
Rev. int. med. cienc. act. fis. deporte ; 17(66): 225-241, jun. 2017. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-164153

RESUMO

El objetivo principal fue analizar las propiedades psicométricas del cuestionario que valora los estilos de enseñanza con los que se identifican preferentemente los docentes de educación física. La muestra estuvo compuesta por 120 docentes de Educación Secundaria. Para el diseño del instrumento se partió del cuestionario DEMEVI al que 12 jueces expertos dieron la validación de contenido. Tras los respectivos análisis factoriales, exploratorios y confirmatorios, se obtuvo un modelo de cinco factores y de 20 ítems presentando índices de ajuste satisfactorios. Se obtuvieron niveles aceptables de consistencia interna y estabilidad temporal. El profesorado menor de 30 años valoraba más los estilos cognitivos, participativos y socializadores, mientras que en función del sexo, los hombres menores de 30 años se identificaban más con estilos de carácter tradicional frente a las mujeres de la misma edad que preferían los cognitivos. El cuestionario de estilos de enseñanza en educación física proporciona evidencias fiables y válidas para su uso (AU)


The objective of the study was to analyze the psychometric properties of the questionnaire which values teaching styles with which preferentially identify physical education teachers. The sample was composed of 120 secondary school teachers. In designing of the instrument they started from a DEMEVI questionnaire to which 12 experts judges got the validation of content. After the respective factor, exploratory and confirmatory analysis, five-factor model and 20 items were obtained, which showed satisfactory indexes of adjustment. Acceptable levels of internal consistency and temporal stability were obtained. Teachers under 30 years valued more the cognitive, participatory and socializing styles while men under 30 years of age identified more with traditional character styles compared to women of the same age who preferred the cognitive ones. The teaching styles questionnaire in physical education provides reliable and valid evidence for use (AU)


Assuntos
Humanos , Educação Física e Treinamento/métodos , Educação Física e Treinamento/organização & administração , Educação Profissionalizante/métodos , Educação Profissionalizante/organização & administração , Avaliação Educacional/normas , Psicometria/métodos , Psicometria/organização & administração , Psicometria/normas , Inquéritos e Questionários , Análise Fatorial , Análise de Variância , Reprodutibilidade dos Testes
20.
Rev. Hosp. Clin. Univ. Chile ; 28(1): 18-26, 2017. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-987217

RESUMO

Pernio (chilblains) is an inflammatory condition classically characterized by localized erythema and swelling of acral sites upon exposure to cool and damp conditions. It is reported a case of a 59-year-old otherwise healthy woman with acute primary perniosis. She had a 3-day history of lesions on the toes brought on by cold, damp weather. On initial presentation, a biopsy sample was taken of a hallux lesion, and the patient was given a trial course of oral pentoxifylline, topical corticoid and nifedipine therapy. Follow-up at 2 weeks showed complete relief of symptoms and the biopsy results confirmed the diagnosis. Pentoxifylline therapy has been shown to be effective and should be considered the standard of care in the treatment of perniosis along with conservative environmental measures.The etiology and pathogenesis of perniosis are reviewed and discussed, as well as differential diagnoses and treatment options. (AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Pérnio/tratamento farmacológico , Pérnio/diagnóstico , Pérnio/prevenção & controle
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