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2.
Nature ; 614(7947): 239-243, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-36755175

RESUMO

Planetary rings are observed not only around giant planets1, but also around small bodies such as the Centaur Chariklo2 and the dwarf planet Haumea3. Up to now, all known dense rings were located close enough to their parent bodies, being inside the Roche limit, where tidal forces prevent material with reasonable densities from aggregating into a satellite. Here we report observations of an inhomogeneous ring around the trans-Neptunian body (50000) Quaoar. This trans-Neptunian object has an estimated radius4 of 555 km and possesses a roughly 80-km satellite5 (Weywot) that orbits at 24 Quaoar radii6,7. The detected ring orbits at 7.4 radii from the central body, which is well outside Quaoar's classical Roche limit, thus indicating that this limit does not always determine where ring material can survive. Our local collisional simulations show that elastic collisions, based on laboratory experiments8, can maintain a ring far away from the body. Moreover, Quaoar's ring orbits close to the 1/3 spin-orbit resonance9 with Quaoar, a property shared by Chariklo's2,10,11 and Haumea's3 rings, suggesting that this resonance plays a key role in ring confinement for small bodies.

3.
Artigo em Espanhol | IBECS | ID: ibc-205207

RESUMO

Introducción: Los inhibidores de la bomba de protones (IBP) son fármacos utilizados frecuentemente para el manejo de diferentes enfermedades gastrointestinales. Aunque sus indicaciones y dosis están bien establecidas, se han comunicado elevadas tasas de maluso. Métodos: Estudio observacional transversal realizado en un servicio de urgencias de un hospital terciario. Pacientes adultos que acudían por distintas patologías fueron invitados a participar. Se evaluó la correcta indicación del IBP, además de su dosis, duración del tratamiento y facultativo prescriptor. Resultados: Se incluyeron 300 pacientes. La indicación se consideró correcta en 142 pacientes (47,3%), siendo la indicación más frecuente la profilaxis de enteropatía inducida por AINE/AAS (n=95; 31,7%). La «gastroprotección» en paciente polimedicados, sin fármacos gastroerosivos fue la principal indicación inadecuada (n=82; 27,3%) seguida de la profilaxis innecesaria en pacientes menores de 60 años tratados en monoterapia con un fármaco gastroerosivo. La mediana del tiempo de prescripción fue de 31 meses (RIC: 9-72) con un intervalo de 1-360 meses. El tiempo de prescripción era inferior en aquellos con indicación correcta (42,3 vs. 59,6 meses, p=0,02). El médico de atención primaria era el prescriptor más frecuente (n=165; 55%), seguido del gastroenterólogo (n=38; 12,7%), sin encontrar diferencias significativas en cuanto a la adecuación de la prescripción. Conclusiones: Estudios como el presente alertan de la persistencia de unas elevadas sobreutilización y maluso de los IBP. La desprescripción, cuando el IBP no está indicado, puede ayudar a controlar el gasto sanitario innecesario y a evitar iatrogenia (AU)


Introduction: Proton-pump inhibitors (PPI) are frequently prescribed for wide gastrointestinal disorders. The indications are well established, although a high rate of misuse has been reported. Methods: Observation cross-sectional study conducted a tertiary hospital. Adult patients who attended the emergency department were eligible. The appropriate indication was evaluated. Also, the prescription period, dosage and the prescribing clinician were reviewed. Results: 300 patients were included. The indication was adequate in 142 patients (47.3%). The main indication was the primary prophylaxis for NSAIDs/ASA-induced enteropathy (n=95 patients, 31.7%). Polypharmacy was the main misuse indication (n=82 patients, 27.3%). The median prescription duration was 31 months (IQR 9-72), ranging from one month to 360 months. The duration was lower in those with correct indication (42.3 vs 59.6 months, P=.02). The primary care physician was the main responsible for prescription (n=165 patients, 55%), followed by gastroenterologist (n=38 patients, 12.7%) without significant differences in appropriateness by speciality. Conclusions: Studies like this raise awareness about the PPI overuse and misuse. Deprescribing should be considered as essential to reduce iatrogenic risk and redundant health expenditure (AU)


Assuntos
Humanos , Masculino , Feminino , Idoso , Idoso de 80 Anos ou mais , Serviço Hospitalar de Emergência , Inibidores da Bomba de Prótons/administração & dosagem , Gastroenteropatias/prevenção & controle , Prescrição Inadequada/prevenção & controle , Inquéritos e Questionários , Estudos Transversais , Polimedicação
4.
Semergen ; 48(2): 82-87, 2022 Mar.
Artigo em Espanhol | MEDLINE | ID: mdl-34728148

RESUMO

INTRODUCTION: Proton-pump inhibitors (PPI) are frequently prescribed for wide gastrointestinal disorders. The indications are well established, although a high rate of misuse has been reported. METHODS: Observation cross-sectional study conducted a tertiary hospital. Adult patients who attended the emergency department were eligible. The appropriate indication was evaluated. Also, the prescription period, dosage and the prescribing clinician were reviewed. RESULTS: 300 patients were included. The indication was adequate in 142 patients (47.3%). The main indication was the primary prophylaxis for NSAIDs/ASA-induced enteropathy (n=95 patients, 31.7%). Polypharmacy was the main misuse indication (n=82 patients, 27.3%). The median prescription duration was 31 months (IQR 9-72), ranging from one month to 360 months. The duration was lower in those with correct indication (42.3 vs 59.6 months, P=.02). The primary care physician was the main responsible for prescription (n=165 patients, 55%), followed by gastroenterologist (n=38 patients, 12.7%) without significant differences in appropriateness by speciality. CONCLUSIONS: Studies like this raise awareness about the PPI overuse and misuse. Deprescribing should be considered as essential to reduce iatrogenic risk and redundant health expenditure.


Assuntos
Prescrição Inadequada , Inibidores da Bomba de Prótons , Adulto , Estudos Transversais , Serviço Hospitalar de Emergência , Humanos , Prescrição Inadequada/prevenção & controle , Polimedicação , Inibidores da Bomba de Prótons/efeitos adversos
5.
Int J Paleopathol ; 30: 1-9, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32109842

RESUMO

OBJECTIVE: Actinomycosis infection of bone is rare and its diagnosis challenging. Here, we aim to identify and verify its microstructural features and the potential value for differential diagnosis. MATERIALS: We investigated the dry preparation of the lumbar vertebrae and pelvic ring of a purported case of actinomycosis documented by a post-mortem examination in 1891. METHODS: Macroscopic inspection, conventional radiology, µCT, 3D reconstruction, and histological examination were employed. RESULTS: All approaches revealed new periosteal bone deposition with increased vascularisation of the os coxa, vertebrae, and sacrum. The µCT revealed cortical loss underneath the new bone formation; the 3D reconstruction and histological examination revealed plexiform bone and granular structures. CONCLUSIONS: The plexiform bone is the result of reactive rapid growth and remodelling processes, and is consistent with pathomorphological findings summarised in the autopsy report (soft tissue abscesses and formation of fistulas caused by "Actinomycosis intestine et ossis ilei sin."). SIGNIFICANCE: This is the first case of a historically documented case of actinomycosis infection investigated by µCT and histology. Different degrees of tissue damage and inflammatory reaction in form of plexiform bone, which has not been reported previously, was identified. LIMITATIONS: The noted bone tissue modifications are not solely pathognomic of actinomycosis; they characterise other diseases, as well. Histological evaluation is not appropriate for identifying the aetiology of the granular structures observed here; but clinically such aggregations appear in tissue affected by actinomycosis. SUGGESTIONS FOR FURTHER RESEARCH: Histochemical and molecular-genetic analyses are obligatory to affirm the diagnosis based on micromorphological features.


Assuntos
Actinomicose , Vértebras Lombares , Ossos Pélvicos , Actinomicose/diagnóstico por imagem , Actinomicose/história , Actinomicose/patologia , Adulto , Feminino , História do Século XIX , Humanos , Imageamento Tridimensional , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/patologia , Paleopatologia , Ossos Pélvicos/diagnóstico por imagem , Ossos Pélvicos/patologia , Microtomografia por Raio-X , Adulto Jovem
6.
Brain Res ; 1719: 235-242, 2019 09 15.
Artigo em Inglês | MEDLINE | ID: mdl-31181184

RESUMO

During adolescence dopaminergic neurotransmission shows transient changes until reaching adulthood. The administration of CB1 agonists such as WIN55212-2 during adulthood increases dopamine extracellular levels. However, the effects of acute administration of cannabinoids on nigrostriatal dopamine neurotransmission during adolescence are not fully elucidated. The aim of this research is to compare dorsolateral striatum (DLS) dopamine (DA) dynamics and to study the effect of WIN55212-2 on DLS DA dynamics during adolescence and adulthood. No-net flux microdialysis experiments were carried out in adolescent (post-natal day 35-40) and young-adult (post-natal day 70-75) urethane-anesthetized rats. Basal DA dialysate, DA extraction fraction (Ed) and extracellular concentration of DA (Cext) in DLS were assessed after an acute injection of WIN55212-2 (1.2 mg/kg) or vehicle. An increased basal DA dialysate and DA Ed were observed during adolescence compared to adulthood. Moreover, WIN55212-2 increases DLS DA Cext rising basal DA dialysate in adulthood and decreasing DA Ed in adolescence. Our results suggest that an age-dependent mechanism underlies the effect of WIN 55212-2 on DA balance between release and uptake in DLS.


Assuntos
Benzoxazinas/farmacologia , Corpo Estriado/efeitos dos fármacos , Dopamina/metabolismo , Morfolinas/farmacologia , Naftalenos/farmacologia , Fatores Etários , Animais , Benzoxazinas/metabolismo , Canabinoides/farmacologia , Dopamina/farmacologia , Masculino , Morfolinas/metabolismo , Naftalenos/metabolismo , Neostriado/efeitos dos fármacos , Ratos , Ratos Sprague-Dawley , Receptor CB1 de Canabinoide/agonistas , Receptor CB1 de Canabinoide/metabolismo , Transmissão Sináptica/efeitos dos fármacos
7.
Nature ; 550(7675): 219-223, 2017 10 11.
Artigo em Inglês | MEDLINE | ID: mdl-29022593

RESUMO

Haumea-one of the four known trans-Neptunian dwarf planets-is a very elongated and rapidly rotating body. In contrast to other dwarf planets, its size, shape, albedo and density are not well constrained. The Centaur Chariklo was the first body other than a giant planet known to have a ring system, and the Centaur Chiron was later found to possess something similar to Chariklo's rings. Here we report observations from multiple Earth-based observatories of Haumea passing in front of a distant star (a multi-chord stellar occultation). Secondary events observed around the main body of Haumea are consistent with the presence of a ring with an opacity of 0.5, width of 70 kilometres and radius of about 2,287 kilometres. The ring is coplanar with both Haumea's equator and the orbit of its satellite Hi'iaka. The radius of the ring places it close to the 3:1 mean-motion resonance with Haumea's spin period-that is, Haumea rotates three times on its axis in the time that a ring particle completes one revolution. The occultation by the main body provides an instantaneous elliptical projected shape with axes of about 1,704 kilometres and 1,138 kilometres. Combined with rotational light curves, the occultation constrains the three-dimensional orientation of Haumea and its triaxial shape, which is inconsistent with a homogeneous body in hydrostatic equilibrium. Haumea's largest axis is at least 2,322 kilometres, larger than previously thought, implying an upper limit for its density of 1,885 kilograms per cubic metre and a geometric albedo of 0.51, both smaller than previous estimates. In addition, this estimate of the density of Haumea is closer to that of Pluto than are previous estimates, in line with expectations. No global nitrogen- or methane-dominated atmosphere was detected.

8.
Environ Manage ; 60(6): 1022-1041, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-28887588

RESUMO

Understanding how to improve decision makers' use of scientific information across their different scales of management is a core challenge for narrowing the gap between science and conservation practice. Here, we present a study conducted in collaboration with decision makers that aims to explore the functionality of the mechanisms for scientific input within the institutional setting of the National Protected Area Network of Peru. First, we analyzed institutional mechanisms to assess the scientific information recorded by decision makers. Second, we developed two workshops involving scientists, decision makers and social actors to identify barriers to evidence-based conservation practice. Third, we administered 482 questionnaires to stakeholders to explore social perceptions of the role of science and the willingness to collaborate in the governance of protected areas. The results revealed that (1) the institutional mechanisms did not effectively promote the compilation and application of scientific knowledge for conservation practice; (2) six important barriers hindered scientific input in management decisions; and (3) stakeholders showed positive perceptions about the involvement of scientists in protected areas and expressed their willingness to collaborate in conservation practice. This collaborative research helped to (1) identify gaps and opportunities that should be addressed for increasing the effectiveness of the institutional mechanisms and (2) support institutional changes integrating science-based strategies for strengthening scientific input in decision-making. These insights provide a useful contextual orientation for scholars and decision makers interested in conducting empirical research to connect scientific inputs with operational aspects of the management cycle in other institutional settings around the world.


Assuntos
Conservação dos Recursos Naturais/métodos , Tomada de Decisões , Política Ambiental/tendências , Pesquisa Interdisciplinar/organização & administração , Formulação de Políticas , Projetos de Pesquisa/tendências , Conservação dos Recursos Naturais/legislação & jurisprudência , Conservação dos Recursos Naturais/tendências , Política Ambiental/legislação & jurisprudência , Regulamentação Governamental , Pesquisa Interdisciplinar/legislação & jurisprudência , Pesquisa Interdisciplinar/tendências , Peru , Projetos de Pesquisa/legislação & jurisprudência
9.
Radiat Prot Dosimetry ; 165(1-4): 107-10, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25805885

RESUMO

The aims of this work were to report the results of a national survey on entrance surface air kerma (ESAK) values for different phantom thicknesses and operation modes in paediatric interventional cardiology (IC) systems and to compare them with previous values. The national survey also offers suggested investigation levels (ILs) for ESAK in paediatric cardiac procedures. ESAK was measured on phantoms of 4-16 cm thickness of polymethyl methacrylate slabs. For low fluoroscopy mode (FM), ESAK rates ranged from 0.11 to 33.1 mGy min(-1) and for high FM from 0.34 to 61.0 mGy min(-1). For cine mode, values of ESAK per frame were from 1.9 to 78.2 µGy fr(-1). The ILs were suggested as the third quartile of the values measured. This research showed lower ESAK values than in previous research, particularly for ESAK values in cine modes. This work represents a first step towards launching a national programme in paediatric dosimetry for IC procedures.


Assuntos
Cardiologia/métodos , Pediatria/métodos , Radiologia Intervencionista/métodos , Ar , Cardiologia/instrumentação , Criança , Chile , Desenho de Equipamento , Fluoroscopia/métodos , Humanos , Pediatria/instrumentação , Imagens de Fantasmas , Polimetil Metacrilato , Doses de Radiação , Intensificação de Imagem Radiográfica/instrumentação , Radiologia Intervencionista/instrumentação , Radiometria/instrumentação , Raios X
10.
Radiat Prot Dosimetry ; 147(1-2): 90-3, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21743071

RESUMO

The aim of this work was to investigate the differences in dose settings and image quality among 10 X-ray systems used for interventional cardiology in Chile. Entrance surface air kerma (ESAK) was measured on a phantom of 20 cm thickness of polymethyl methacrylate slabs. Image quality was evaluated using DICOM images of a test object Leeds TOR 18-FG for cine mode acquisition, through the numerical parameters signal-to-noise ratio (SNR), high-contrast spatial resolution (HCSR) and figure of merit. ESAK rate values for fluoroscopy modes ranged between 7.1 and 121.7 mGy min(-1). For cine mode, ESAK values per frame ranged from 63 to 400 µGy fr(-1). SNR and HCSR parameters for cine mode varied from 4.8 to 8.6 and 0.4 to 10, respectively. FOM values resulted from 6.9 to 64.5 among the different X-ray systems. Results show important differences between systems and point out the need to launch an optimisation programme.


Assuntos
Cardiologia/instrumentação , Coração/diagnóstico por imagem , Processamento de Imagem Assistida por Computador , Doses de Radiação , Radiografia Intervencionista , Adulto , Chile , Humanos , Imagens de Fantasmas , Polimetil Metacrilato/química
11.
Rev. Méd. Clín. Condes ; 19(4): 353-359, sept. 2008. tab
Artigo em Espanhol | LILACS | ID: lil-504161

RESUMO

El síndrome de intestino irritable es un cuadro clínico frecuente caracterizado por malestar/dolor y ditensión abdominal, diarrea, constipación o alternancia de estos síntomas. Tiene un carácter crónico recurrente. El diagnóstico se basa en el cuadro clínico y en la ausencia de síntomas y signos patológicos en los exámenes de rutina. La fisiopatología es compleja y no totalmente esclarecida, reconociéndose la importancia del estrés emocional, las alteraciones de la relación flora intestinal/sistema inmune de la mucosa intestinal y en algunos casos el antecedente de una infección entérica. Es de buen pronóstico y su tratamiento es sintomático. Es importante una óptima relación médico/paciente.


The irritable bowel syndrome is a clinical entity characterized by abdominal distention and pain/discomfort associated with changes in the bowel habit, diarrhoea, constipation or alternating of these symptons. It is a chronic and recurrent condition. Diagnosis is based in the clinical presentation and in the absence of symptoms and signs of severity. The pathophysiology is complex and not completely elucidated although the importance of psychological stress and changes in the relationship of the intestinal flora with the intestinal mucosal immune system are recognized. In some cases a history of intestinal infections is identified. The treatment is addressed to control the symptoms and the prognosis is good. An optimal relationship between the doctor and the patient is of paramount importance.


Assuntos
Humanos , Síndrome do Intestino Irritável/diagnóstico , Síndrome do Intestino Irritável/etiologia , Síndrome do Intestino Irritável/terapia , Diagnóstico Diferencial , Fatores de Risco , Síndrome do Intestino Irritável/fisiopatologia
12.
Rev. Méd. Clín. Condes ; 19(4): 316-321, sept. 2008. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-504165

RESUMO

El esófago de Barrett (EB) es una complicación frecuente de la enfermedad por reflujo gastroesofágico y es un factor importante en el desarrollo de adenocarcinoma esofágico. El EB es sospechado por los hallazgos en la endoscopia y su diagnóstico se confirma cuando la histología demuestra la presencia de metaplasia intestinal en la mucosa esofágica. Dado que la mayoría de los pacientes con EB no desarrollará cáncer de esófago, es necesario definir nuevas estrategias que ayuden a identificar pacientes de mayor riesgo. Aunque la vigilancia de los pacientes con EB está basada aún en la toma sistemática de biopsias de la mucosa con metaplasia, nuevas técnicas endoscópicas de alta resolución pueden ayudar en el proceso de selección. El tratamiento endoscópico de la displasia en pacientes con EB es una nueva modalidad que espera mayor estudio para precisar su indicación.


Barrett's esophagus (BE) is a common complication of gastroesophageal re flux disease and is a major risk factor in the development of esophageal adenocarcinoma. BE is detected on endoscopy and confirmed when histology shows intestinal metaplasia. The majority of Barretts patients will not develop cancer of the esophagus, so new specific methods of identification of those at risk are needed. Although the surveillance of patients with BE is still based on systematic biopsy sampling of Barrett's mucosa endoscopy.


Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Adenocarcinoma , Esôfago de Barrett/diagnóstico , Esôfago de Barrett/patologia , Esôfago de Barrett/terapia , Neoplasias Esofágicas/diagnóstico , Neoplasias Esofágicas/patologia , Endoscopia Gastrointestinal , Refluxo Gastroesofágico/patologia
14.
Rev. Hosp. Matern. Infant. Ramon Sarda ; 27(1): 11-17, 2008. tab, graf
Artigo em Espanhol | LILACS | ID: lil-497626

RESUMO

Introducción: La pérdida insensible de agua (PIA) es mayor a menor edad gestacional y peso de nacimiento. El método estándar para reducirlas es mantener al recién nacido en un ônidoõ, con un gorro y cubierto por una lámina de plástico. Hipótesis: Una alta HR (HRA) en la incubadora (80 por ciento) es más eficaz para reducir la PIA durante las primeras 72 horas de vida, comparado con baja HR (HRB). Diseño: Ensayo clínico controlado y aleatorizado. Objetivo: Determinar si la PIA se reduce significativamente en una incubadora con alta HR. Población y Métodos: RN <1.500 g de peso y 32 semanas de edad gestacional colocados en una Incubadora NATAL CARE® fueron asignados a recibir HRB o alta. Se realizó control de peso, líquidos aportados, diuresis y natremia durante los primeros 3 días. Resultados: Ingresaron 20 pacientes con HRB y 21 con HRA. No se hallaron diferencias clínicas entre ellos. El máximo descenso de peso fue de 8,9 por ciento para el grupo HRA y de 14,5 por ciento para el grupo HRB (p <0,001); la recuperación del peso de nacimiento fue de 10,3 días para el grupo HRA y 16 días para el de HRB (p <0,001), la media de líquidos aportados fue de 87 y 104,4 ml/kg/día respectivamente (p <0,001). La natremia del grupo HRA fue de 134,1 mEq/l y 138,6 mEq/l para HRB (p<0,0001), se registraron 7 casos de hipernatremia en el grupo control. Conclusiones: Estos resultados indirectamente confirman que los recién nacidos prematuros manejados en un microclima de HRA, tienen menos PIA sin aumentar sus riesgos en los primeros días.


Assuntos
Humanos , Recém-Nascido , Regulação da Temperatura Corporal , Recém-Nascido Prematuro , Recém-Nascido de muito Baixo Peso , Perda Insensível de Água , Peso Corporal , Desenho de Equipamento , Umidade , Hipernatremia , Incubadoras para Lactentes , Mortalidade Infantil , Unidades de Terapia Intensiva Neonatal , Pele/crescimento & desenvolvimento , Ensaios Clínicos Controlados Aleatórios como Assunto
15.
Rev. esp. pediatr. (Ed. impr.) ; 63(1): 76-83, ene.-feb. 2007. tab
Artigo em Espanhol | IBECS | ID: ibc-61933

RESUMO

El artículo presenta los datos actuales básicos sobre consumo de tabaco, alcohol y otras drogas por parte de los adolescentes españoles y su evolución en los últimos años. Posteriormente se ofrece un apartado dedicado a subrayar el carácter sociológico de los consumos de drogas expuestos. La principal tesis del artículo, en este sentido, es que dichos consumos se encuentran directamente vinculados con valores, actitudes y otras circunstancias de carácter social, que los enmarcan y, en gran medida, condicionan. Finalmente, se hace una reflexión acerca de los riesgos personales y sociales que pueden derivarse de la situación actual de los consumos, en los niveles en los que han sido expuesto y con el carácter sintónico que poseen para los estilos de vida dominantes actualmente (AU)


This document present some basic data about use of tobacco, alcohol and other drugs for Spanish adolescent population, and its development last years. We offer a paragraph devoted to emphasize these drug consumes, at a sociological level, later. Principal thesis underlying in this article, as we mentioned above, is that drug´s abuse links to a scale of values and circumstances, and it tends to condition itself. Finally, we propose a reflection about personal and social risks derivated from present situation, according to consumer’s levels and its nature for our prevailing way of life (AU)


Assuntos
Humanos , Masculino , Feminino , Adolescente , Saúde do Adolescente , Fumar/epidemiologia , Comportamento do Adolescente/fisiologia , Comportamento do Adolescente/psicologia , Comportamento do Adolescente , Transtornos Relacionados ao Uso de Substâncias/epidemiologia , Estilo de Vida , Serviços de Saúde do Adolescente , Tabagismo/epidemiologia , Desenvolvimento do Adolescente , Desenvolvimento do Adolescente/fisiologia , Codependência Psicológica , Codependência Psicológica/fisiologia
16.
Rev. méd. Chile ; 134(12): 1524-1529, dic. 2006. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-441430

RESUMO

Background: Many patients with irritable bowel syndrome (IBS) have lowered sensory thresholds to rectal distention when compared to control subjects, a phenomenon called visceral hypersensitivity. Aim: To investigate the usefulness of a rectal barostat as a diagnostic tool in IBS and if there are differences in visceral hypersensitivity in different groups of IBS patients. Patients and Methods: Ten healthy subjects and 19 IBS patients, defined using Rome II criteria (12 with constipation, three with diarrhea and four alternating between diarrhea and constipation), were studied. Sequential isobaric rectal distentions, from 2 mmHg up to a maximal pressure of 52 mmHg or when the patients reported pain, were carried out. Visceral hypersensitivity was defined as a pain threshold under 38 mmHg. Results: Only 26 percent of IBS patients had visceral hypersensitivity (16 percent and 43 percent of patients with IBS and constipation and IBS and diarrhea or alternating symptoms, respectively, p =NS). Pain threshold in controls, patients with IBS and constipation and patients with IBS and diarrhea or alternating symptoms was 43.8±6.6, 45.3±9.2 and 40.8±9.2 mmHg, respectively (p =NS). Conclusions: Our results do not support the usefulness of the electronic rectal barostat as a diagnostic method to diagnose IBS.


Assuntos
Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Hiperalgesia/fisiopatologia , Síndrome do Intestino Irritável/fisiopatologia , Limiar da Dor/fisiologia , Estudos de Casos e Controles , Hiperalgesia/etiologia , Síndrome do Intestino Irritável/complicações , Reto/fisiopatologia , Reprodutibilidade dos Testes , Vísceras/fisiopatologia
17.
Cir. pediátr ; 19(4): 247-249, oct. 2006. ilus
Artigo em Es | IBECS | ID: ibc-051868

RESUMO

El vólvulo gástrico es una patología rara en la población pediátrica, en la cual hay una rotación anormal de una parte del estómago alrededor de otra. Se considera una emergencia quirúrgica. El caso presentado es un paciente de sexo femenino de 6 años, ingresado con cuadro de dolor abdominal de 24 horas de evolución, náuseas sin vómito y acompañado de distensión de hemiabdomen superior, doloroso a la palpación y con ausencia de ruidos hidroaéreos. Se realiza laparotomía encontrando vólvulo gástrico con compromiso vascular. En su evolución posquirúrgica requiere segunda exploración por presentar síndrome adherencial (AU)


: Gastric volvulus is a rare condition in pediatric population in which there is an abnormal rotation of one part of the stomach around itself. It´s a surgical emergency. We report a six year old female admitted in the emergency due to upper abdominal distention, nausea without vomiting, physical exam revealed upper abdominal distention and abdominal tenderness, no bowel sounds. Laparotomy was performed and a gastric volvulus with occlusive vascular involvement was found. In the post operative period she required a second laparotomy due to adhesions in small bowel (AU)


Assuntos
Feminino , Criança , Humanos , Volvo Gástrico/complicações , Volvo Gástrico/diagnóstico , Volvo Gástrico/cirurgia , Laparotomia/métodos , Dor Abdominal/complicações , Dor/diagnóstico , Dor/etiologia , Transtornos Traumáticos Cumulativos/complicações , Transtornos Traumáticos Cumulativos/diagnóstico , Medicina de Emergência/métodos , Náusea/complicações , Náusea/diagnóstico
18.
J Oral Rehabil ; 33(3): 194-201, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16512885

RESUMO

Head and cervical posture evaluation has been a concern for many years, not only because of the purported relationship that exists between head and cervical posture in the presence of temporomandibular disorders, neck pain and headache, but also because of the biomechanical relationship between the head and cervical spine and dentofacial structures. Many methods have been suggested in an attempt to establish the best way to evaluate the position of the head using teleradiographs and cephalometric analysis. However, there is still no agreement as to which procedure is the best. The objective of this study was to evaluate the differences that exist between craniocervical measurements in lateral teleradiographs when comparing the position of the head in the self-balanced position to the position of the head using the Frankfurt method (Frankfurt plane parallel to the floor). Sixty-eight subjects who sought dental treatment in community health centres in Talca, Chile participated in this study. Rocabado analysis was used to measure the craniocervical variables. The Cobb analysis was used to measure cervical lordosis. A paired student t-test was used to evaluate the differences between both procedures, using an alpha of 0.05 and a power of 0.90. The use of the cephalostat changed only the craniocervical angle (P < 0.001). However, this change was minimal. No changes related to gender and age were found. More studies are needed to determine the variation between different procedures and to define a good procedure for evaluating head posture.


Assuntos
Cabeça , Pescoço , Postura , Adolescente , Adulto , Fatores Etários , Cefalometria/métodos , Vértebras Cervicais , Criança , Pré-Escolar , Feminino , Cabeça/diagnóstico por imagem , Humanos , Lordose/patologia , Masculino , Pescoço/diagnóstico por imagem , Radiografia , Reprodutibilidade dos Testes , Fatores Sexuais
19.
Gastroenterol. latinoam ; 17(1): 13-22, ene.-mar. 2006. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-430763

RESUMO

El tromboembolismo (TE) arterial y venoso, posee una elevada morbimortalidad, siendo en pacientes con enfermedades inflamatorias intestinales (EII) 3-4 veces mayor que la población general, con una prevalencia de un 2-10 por ciento. El mecanismo por el cual la actividad procoagulante está aumentada en las EII es aún desconocido, sin embargo, factores de riesgo como el grado de inflamación de la mucosa han sido descritos. Objetivos: Determinar las características clínicas de TE en un grupo de pacientes con EII. Pacientes y Métodos: Se analizaron de manera retrospectiva los antecedentes clínicos de 16 pacientes con EII que presentaron TE durante su evolución. Se evaluó edad, extensión y grado de actividad de la EII al momento del TE. Resultados: Los pacientes estudiados fueron 13 con colitis ulcerosa (CU) y tres con enfermedad de Crohn (EC), edad promedio 43 años (rango 21-72), ocho mujeres. Once pacientes tenían < 50 años al momento del TE. En CU, nueve pacientes tenían pancolitis, todos con enfermedad activa moderada-severa. En EC, dos pacientes presentaban actividad de la enfermedad al momento del TE. Tres pacientes tenían otra manifestación extraintestinal (MEI), dos de ellos artralgias y uno colangitis esclerosante primaria. Los eventos de TE son: trombosis venosa profunda de extremidades inferiores en 9 casos; TE pulmonar en 3 pacientes, trombosis mesentérica/portal (dos casos), trombosis del seno venoso longitudinal (un paciente), trombosis arteria cerebral (uno) y trombosis de arteria braquial un caso). Quince casos de TE ocurrieron entre una semana y 6 años luego del diagnóstico de EII. Cinco pacientes estaban hospitalizados al momento del TE, dos de ellos después de cirugía por su EII. Ningún paciente estaba recibiendo nutrición parenteral total o tenía catéter venoso central al momento del TE. El estudio de trombofilia realizado en cinco pacientes, no demostró alteraciones características. Todos los pacientes fueron tratados con heparina sin complicaciones, y un paciente falleció por embolia pulmonar. Ningún paciente tenía antecedentes personales o familiares de TE. Conclusiones: El tromboembolismo es otra MEI de las EII que debe ser sospechado. La remisión de la EII pudiera ser el factor más importante en la prevención de estos episodios. El uso de heparina como tratamiento del TE no está contraindicado en estos pacientes, incluso en aquellos con crisis severa con sangramiento intestinal.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Doenças Inflamatórias Intestinais/complicações , Tromboembolia/etiologia , Cérebro , Colite Ulcerativa/complicações , Embolia Pulmonar/etiologia , Doença de Crohn/complicações , Estudos Retrospectivos , Fatores de Risco , Heparina/uso terapêutico , Tromboembolia/diagnóstico , Tromboembolia/tratamento farmacológico , Trombose Venosa/etiologia
20.
Cir Pediatr ; 19(4): 247-9, 2006 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-17352117

RESUMO

Gastric volvulus is a rare condition in pediatric population in which there is an abnormal rotation of one part of the stomach around itself. It's a surgical emergency. We report a six year old female admitted in the emergency due to upper abdominal distention, nausea without vomiting, physical exam revealed upper abdominal distention and abdominal tenderness, no bowel sounds. Laparotomy was performed and a gastric volvulus with occlusive vascular involvement was found. In the post operative period she required a second laparotomy due to adhesions in small bowel.


Assuntos
Volvo Gástrico/diagnóstico por imagem , Criança , Procedimentos Cirúrgicos do Sistema Digestório , Feminino , Humanos , Radiografia Abdominal , Volvo Gástrico/cirurgia , Resultado do Tratamento
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