BRAZILIAN MULTI-SOCIETY POSITION STATEMENT ON EMERGING BARIATRIC AND METABOLIC SURGICAL PROCEDURES.

This Brazilian multi-society position statement on emerging bariatric and metabolic surgical procedures was issued by the Brazilian Society of Bariatric and Metabolic Surgery (SBCBM), the Brazilian College of Digestive Surgery (CBCD), and the Brazilian College of Surgeons (CBC). This document is the result of a Brazilian Emerging Surgeries Forum aimed at evaluating the results of surgeries that are not yet listed in the Federal Council of Medicine (CFM), the regulatory agency that oversees and regulates medical practice in Brazil. The Forum integrated more than 400 specialists and academics with extensive knowledge about bariatric and metabolic surgery, representing the three surgical societies: SBCBM, CBC, and CBCD. International speakers participated online and presented their experiences with the techniques under discussion, emphasizing the regulatory policies in their countries. The indications for surgery and the subsequent procedures were carefully reviewed, including one anastomosis gastric bypass (OAGB), single anastomosis duodeno-ileal with sleeve gastrectomy (SADI-S or OADS), sleeve gastrectomy with transit bipartition (SGTB), and sleeve gastrectomy with ileal interposition (SGII). The recommendations of this document are based on an extensive literature review and discussions among bariatric surgery specialists from the three surgical societies. We concluded that patients with a body mass index over 30 kg/m2 may be candidates for metabolic surgery in the presence of comorbidities (arterial hypertension and type 2 diabetes) with no response to clinical treatment of obesity or in the control of other associated diseases. Regarding the surgical procedures, we concluded that OAGB, OADS, and SGTB are associated with low morbidity rates, satisfactory weight loss, and resolution of obesity-related comorbidities such as diabetes and arterial hypertension. SGII was considered a good and viable promising surgical alternative technique. The recommendations of this statement aim to synchronize our societies with the sentiments and understandings of most of our members and also serve as a guide for future decisions regarding bariatric surgical procedures in our country and worldwide.

BRAZILIAN MULTI-SOCIETY POSITION STATEMENT ON EMERGING BARIATRIC AND METABOLIC SURGICAL PROCEDURES / POSIÇÃO DAS SOCIEDADES BRASILEIRAS SOBRE PROCEDIMENTOS CIRÚRGICOS BARIÁTRICOS E METABÓLICOS EMERGENTES

This Brazilian multi-society position statement on emerging bariatric and metabolic surgical procedures was issued by the Brazilian Society of Bariatric and Metabolic Surgery (SBCBM), the Brazilian College of Digestive Surgery (CBCD), and the Brazilian College of Surgeons (CBC). This document is the result of a Brazilian Emerging Surgeries Forum aimed at evaluating the results of surgeries that are not yet listed in the Federal Council of Medicine (CFM), the regulatory agency that oversees and regulates medical practice in Brazil. The Forum integrated more than 400 specialists and academics with extensive knowledge about bariatric and metabolic surgery, representing the three surgical societies: SBCBM, CBC, and CBC. International speakers participated online and presented their experiences with the techniques under discussion, emphasizing the regulatory policies in their countries. The indications for surgery and the subsequent procedures were carefully reviewed, including One Anastomosis Gastric Bypass (OAGB), Single Anastomosis Duodeno-Ileal with Sleeve Gastrectomy (OADS or SADI-S), Sleeve Gastrectomy with Transit Bipartition (SGTB), and Sleeve Gastrectomy with Ileal Interposition (SGII). The recommendations of this document are based on an extensive literature review and discussions among bariatric surgery specialists from the three surgical societies. We concluded that patients with a body mass index (BMI) over 30 kg/m2 may be candidates for metabolic surgery in the presence of comorbidities (arterial hypertension and type 2 diabetes) with no response to clinical treatment of obesity or in the control of other associated diseases. Regarding the surgical procedures, we concluded that OAGB, OADS, and SGTB are associated with low morbidity rates and with satisfactory weight loss and resolution of obesity-related comorbidities such as diabetes and arterial hypertension. SGII was considered a good and viable promising surgical alternative technique. The recommendations of this statement aim to synchronize our societies with the sentiments and understandings of most of our members and also serve as a guide for future decisions regarding bariatric surgical procedures in our country and worldwide.

Esta declaração multissocietária de posicionamento sobre novos procedimentos cirúrgicos bariátricos e metabólicos emergentes foi emitida pela Sociedade Brasileira de Cirurgia Bariátrica e Metabólica (SBCBM), pelo Colégio Brasileiro de Cirurgia Digestiva (CBCD) e pelo Colégio Brasileiro de Cirurgiões (CBC). Este documento é resultado do Fórum Brasileiro de Cirurgias Emergentes, realizado com o objetivo de avaliar os resultados de cirurgias ainda não listadas no Conselho Federal de Medicina (CFM), órgão regulador que fiscaliza e regulamenta a prática médica no Brasil. O Fórum integrou mais de 400 especialistas e acadêmicos com amplo conhecimento sobre cirurgia bariátrica e metabólica, representando as três sociedades cirúrgicas: SBCBM, CBC e CBC. Palestrantes internacionais participaram online e apresentaram suas experiências com as técnicas em discussão, enfatizando as políticas regulatórias de seus países. As indicações para cirurgia e os procedimentos subsequentes foram cuidadosamente revisados, incluindo bypass gástrico de uma anastomose (OAGB), anastomose duodeno-Ileal única com gastrectomia vertical (OADS ou SADI-S), gastrectomia vertical com bipartição de trânsito (SGTB) e gastrectomia vertical com interposição ileal (SGII). As recomendações deste documento são baseadas em extensa revisão da literatura e discussões entre especialistas em cirurgia bariátrica das três sociedades cirúrgicas. Concluímos que pacientes com índice de massa corpórea (IMC) acima de 30 kg/m2 podem ser candidatos à cirurgia metabólica na presença de comorbidades (hipertensão arterial e diabetes tipo 2), sem resposta ao tratamento clínico da obesidade ou no controle de outras doenças associadas. Em relação aos procedimentos cirúrgicos, concluímos que OAGB, OADS e SGTB estão associados a baixas taxas de morbidade e com perda de peso satisfatória e resolução de comorbidades relacionadas à obesidade, como diabetes e hipertensão arterial. A SGII foi considerada uma boa e viável técnica cirúrgica, sendo considerada uma alternativa promissora. As recomendações desta declaração visam sincronizar nossas sociedades com os sentimentos e entendimentos da maioria de nossos membros e também servir como um guia para futuras decisões sobre procedimentos cirúrgicos bariátricos em nosso país e no mundo.

Brazilian multi-society position statement on emerging bariatric and metabolic surgical procedures / Posição das sociedades brasileiras sobre procedimentos cirúrgicos bariátricos e metabólicos emergentes

ABSTRACT This Brazilian multi-society position statement on emerging bariatric and metabolic surgical procedures was issued by the Brazilian Society of Bariatric and Metabolic Surgery (SBCBM), the Brazilian College of Digestive Surgery (CBCD), and the Brazilian College of Surgeons (CBC). This document is the result of a Brazilian Emerging Surgeries Forum aimed at evaluating the results of surgeries that are not yet listed in the Federal Council of Medicine (CFM), the regulatory agency that oversees and regulates medical practice in Brazil. The Forum integrated more than 400 specialists and academics with extensive knowledge about bariatric and metabolic surgery, representing the three surgical societies: SBCBM, CBC, and CBCD. International speakers participated online and presented their experiences with the techniques under discussion, emphasizing the regulatory policies in their countries. The indications for surgery and the subsequent procedures were carefully reviewed, including one anastomosis gastric bypass (OAGB), single anastomosis duodeno-ileal with sleeve gastrectomy (SADI-S or OADS), sleeve gastrectomy with transit bipartition (SGTB), and sleeve gastrectomy with ileal interposition (SGII). The recommendations of this document are based on an extensive literature review and discussions among bariatric surgery specialists from the three surgical societies. We concluded that patients with a body mass index over 30 kg/m2 may be candidates for metabolic surgery in the presence of comorbidities (arterial hypertension and type 2 diabetes) with no response to clinical treatment of obesity or in the control of other associated diseases. Regarding the surgical procedures, we concluded that OAGB, OADS, and SGTB are associated with low morbidity rates, satisfactory weight loss, and resolution of obesity-related comorbidities such as diabetes and arterial hypertension. SGII was considered a good and viable promising surgical alternative technique. The recommendations of this statement aim to synchronize our societies with the sentiments and understandings of most of our members and also serve as a guide for future decisions regarding bariatric surgical procedures in our country and worldwide.

RESUMO Esta declaração multissocietária de posicionamento sobre novos procedimentos cirúrgicos bariátricos e metabólicos emergentes foi emitida pela Sociedade Brasileira de Cirurgia Bariátrica e Metabólica (SBCBM), pelo Colégio Brasileiro de Cirurgia Digestiva (CBCD) e pelo Colégio Brasileiro de Cirurgiões (CBC). Este documento é resultado do Fórum Brasileiro de Cirurgias Emergentes, realizado com o objetivo de avaliar os resultados de cirurgias ainda não listadas no Conselho Federal de Medicina (CFM), órgão regulador que fiscaliza e regulamenta a prática médica no Brasil. O Fórum integrou mais de 400 especialistas e acadêmicos com amplo conhecimento sobre cirurgia bariátrica e metabólica, representando as três sociedades cirúrgicas: SBCBM, CBC e CBCD. Palestrantes internacionais participaram online e apresentaram suas experiências com as técnicas em discussão, enfatizando as políticas regulatórias de seus países. As indicações para cirurgia e os procedimentos subsequentes foram cuidadosamente revisados, incluindo bypass gástrico de uma anastomose (OAGB), anastomose duodeno-Ileal única com gastrectomia vertical (OADS ou SADI-S), gastrectomia vertical com bipartição de trânsito (SGTB) e gastrectomia vertical com interposição ileal (SGII). As recomendações deste documento são baseadas em extensa revisão da literatura e discussões entre especialistas em cirurgia bariátrica das três sociedades cirúrgicas. Concluímos que pacientes com índice de massa corpórea (IMC) acima de 30 kg/m2 podem ser candidatos à cirurgia metabólica na presença de comorbidades (hipertensão arterial e diabetes tipo 2), sem resposta ao tratamento clínico da obesidade ou no controle de outras doenças associadas. Em relação aos procedimentos cirúrgicos, concluímos que OAGB, OADS e SGTB estão associados a baixas taxas de morbidade e com perda de peso satisfatória e resolução de comorbidades relacionadas à obesidade, como diabetes e hipertensão arterial. A SGII foi considerada uma boa e viável técnica cirúrgica, sendo considerada uma alternativa promissora. As recomendações desta declaração visam sincronizar nossas sociedades com os sentimentos e entendimentos da maioria de nossos membros e também servir como um guia para futuras decisões sobre procedimentos cirúrgicos bariátricos em nosso país e no mundo.

Influence of Gastric Bypass on Obese Women Sexual Function-a Prospective Study.

INTRODUCTION: Obesity may lead to hyperandrogenia and affect female sexual function. The study aims to evaluate female sexual function and androgenic profile in obese women after laparoscopic Roux-en-Y gastric bypass (LRYGB). METHODS: Forty obese women with a mean age of 34 years were prospectively studied. Diabetes and psychiatric and pelvic disorders were the exclusion criteria. All patients underwent LRYGB. Total (TT) and free (FT) testosterone, androstenedione (AD), dehydroepiandrosterone (DHEA) and the Sexual Quotient - Female Version were evaluated, preoperatively, 6 and 12 months after the operation. RESULTS: Preoperative incidence of sexual dysfunction was 10% and hyperandrogenia was 40%. At 6 months, sexual function was not different; and FT (0.49-0.33 ng/dl) and AD (2.0-1.3 ng/dl) decreased significantly. At 12 months, there was an improvement in female sexual function (77-84 points), related to desire and interest (22-25 points) and comfort (15.9-17.3 points) without case of sexual dysfunction at 12 months. Hyperandrogenia (40-8%), FT levels (0.5-0.3 ng/dl), and AD (2.0-1.4 ng/dl) decreased, while DHEA levels (3.4-4.2 ng/dl) increased. The percentage of weight loss was 22% and 31% at 6 and 12 months, respectively. Sexual function did not correlate with BMI, weight, or androgen levels in any period. CONCLUSION: Female sexual function in obese women with no diabetes and psychiatric and pelvic disorders improved in patients undergoing LRYGB, especially in desire, interest, and sexual comfort, and this occured after 6 months of the operation and unrelated to BMI, percentage of weight loss, or androgen levels. KEY POINTS: • In obese women with no diabetes and psychiatric and pelvic disorders the FSD improvement after LRYGB. • FSD no correlation with weight loss and BMI. • FSD no correlation with androgens levels.

Preoperative progressive pneumoperitoneum in obese patients with loss of domain hernias.

BACKGROUND: Repair of hernias with loss of domain in obese patients can lead to acute respiratory failure. OBJECTIVES: The objective of this study was to analyze preoperative progressive pneumoperitoneum (PPP) in increasing abdominal cavity volume and its impact on respiratory function. SETTING: The study was conducted at the University Hospital, State University of Londrina, Brazil, which is a referral center for the treatment of obesity. The patients were hospitalized for the duration of the study. METHODS: Sixteen obese patients were evaluated. Computed tomography was used to determine hernia sac volume (HSV) and abdominal cavity volume (ACV). Respiratory function was evaluated by measuring vital capacity and forced expiratory volume in the first second (FEV-1). All data were obtained before PPP, on the day before surgery, and on the second postoperative day. PPP was performed daily with insufflation of CO2. RESULTS: The number of insufflations was 12. The average of total volume inflated was 5.7 L. The HSV was 2953 cm3 before PPP and 1935 cm3 after PPP. The average ACV increased from 8898 to 11,317 cm3 after PPP. The relationship between HSV and ACV was 38.2% before and 16.3% after PPP. There was a favorable improvement in respiratory function with an increase in vital capacity from 1875 to 2760 mL and an increase in FEV-1 from 1060 to 1670 mL after PPP. Respiratory function tests after surgery showed values of 2600 and 1560 mL, respectively, for cavity volume and FEV-1. There were no postoperative respiratory complications. CONCLUSIONS: This technique can be used safely in the surgical preparation of obese patients with hernias with loss of domain, reducing the relation between HSV and ACV and avoiding pulmonary complications.

PREOPERATIVE MANOMETRY FOR THE SELECTION OF OBESE PEOPLE CANDIDATE TO SLEEVE GASTRECTOMY.

BACKGROUND: Sleeve gastrectomy may alter esophageal motility and lower esophageal sphincter pressure. AIM: To detect manometric changings in the esophagus and lower esophageal sphincter before and after sleeve gastrectomy in order to select patients who could develop postoperative esophageal motilitity disorders and lower esophageal sphincter pressure modifications. METHODS: Seventy-three patients were selected. All were submitted to manometry before the operation and one year after. The variables analyzed were: resting pressure of the lower esophageal sphincter, contraction wave amplitude, duration of contraction waves, and esophageal peristalsis. Data were compared before and after surgery and to the healthy and non-obese control group. Exclusion criteria were: previous gastric surgery, reflux symptoms or endoscopic findings of reflux or hiatal hernia, diabetes and use of medications that could affect esophageal or lower esophageal sphincter motility. RESULTS: 49% of the patients presented preoperative manometric alterations: lower esophageal sphincter hypertonia in 47%, lower esophageal sphincter hypotonia in 22% and increase in contraction wave amplitude in 31%. One year after surgery, manometry was altered in 85% of patients: lower esophageal sphincter hypertonia in 11%, lower esophageal sphincter hypotonia in 52%, increase in contraction wave amplitude in 27% and 10% with alteration in esophageal peristalsis. Comparing the results between the preoperative and postoperative periods, was found statistical significance for the variables of the lower esophageal sphincter, amplitude of contraction waves and peristalsis. CONCLUSION: Manometry in the preoperative period of sleeve gastrectomy is not an exam to select candidates to this technique.

Preoperative manometry for the selection of obese people candidate to sleeve gastrectomy / Manometria pré-operatória para a seleção de obesos candidatos à gastrectomia vertical

ABSTRACT Background: Sleeve gastrectomy may alter esophageal motility and lower esophageal sphincter pressure. Aim: To detect manometric changings in the esophagus and lower esophageal sphincter before and after sleeve gastrectomy in order to select patients who could develop postoperative esophageal motilitity disorders and lower esophageal sphincter pressure modifications. Methods: Seventy-three patients were selected. All were submitted to manometry before the operation and one year after. The variables analyzed were: resting pressure of the lower esophageal sphincter, contraction wave amplitude, duration of contraction waves, and esophageal peristalsis. Data were compared before and after surgery and to the healthy and non-obese control group. Exclusion criteria were: previous gastric surgery, reflux symptoms or endoscopic findings of reflux or hiatal hernia, diabetes and use of medications that could affect esophageal or lower esophageal sphincter motility. Results: 49% of the patients presented preoperative manometric alterations: lower esophageal sphincter hypertonia in 47%, lower esophageal sphincter hypotonia in 22% and increase in contraction wave amplitude in 31%. One year after surgery, manometry was altered in 85% of patients: lower esophageal sphincter hypertonia in 11%, lower esophageal sphincter hypotonia in 52%, increase in contraction wave amplitude in 27% and 10% with alteration in esophageal peristalsis. Comparing the results between the preoperative and postoperative periods, was found statistical significance for the variables of the lower esophageal sphincter, amplitude of contraction waves and peristalsis. Conclusion: Manometry in the preoperative period of sleeve gastrectomy is not an exam to select candidates to this technique.

RESUMO Racional: A gastrectomia vertical pode determinar alterações na motilidade esofágica e no esfíncter inferior do esôfago. Objetivo: Estudar as alterações manométricas do esfíncter inferior do esôfago e do esôfago antes e depois da operação a fim de selecionar pacientes que pudessem desenvolver alterações pós-operatórias. Métodos: Setenta e três pacientes foram selecionados. Todos foram submetidos à manometria antes da operação e um ano após. As variáveis analisadas foram: pressão do esfíncter inferior do esôfago, amplitude e duração das ondas de contração e peristaltismo esofágico. Os dados foram comparados entre si antes e depois da operação e também com grupo controle saudável e não obeso. Critérios de exclusão foram: operação gástrica prévia, história de refluxo ou achado endoscópico de esofagite de refluxo ou de hérnia de hiato, diabete e uso de medicamentos que pudessem afetar a motilidade do esôfago ou do esfíncter esofágico inferior. Resultados: 49% dos pacientes apresentaram alterações no pré-operatório: hipertonia do esfíncter em 47%, hipotonia do esfíncter em 22% e aumento na amplitude das ondas de contração em 31%. Um ano após, a manometria encontrou-se alterada em 85% dos pacientes: hipertonia do esfíncter em 11%, hipotonia do esfíncter em 52%, aumento na amplitude das ondas de contração em 27% e 10% com alteração no peristaltismo esofágico. Comparando-se os resultados entre o pré e pós-operatório encontrou-se significância estatística para a pressão do esfíncter inferior do esôfago, amplitude das ondas de contração e peristaltismo. Conclusão: A manometria no pré-operatório da gastrectomia vertical não é fator de seleção dos candidatos a essa técnica.

Roux-en-Y gastric bypass: limb length and weight loss.

BACKGROUND: Roux-en-Y gastric bypass is a surgical technique widely used in the treatment of obesity. It is unclear, however, if the length of the biliopancreatic and alimentary limb interferes with the magnitude of weight loss. AIM: To evaluate if the length of these limbs is related to the percentage of weight loss one year after surgery. METHOD: One hundred and twenty obese people underwent surgery between 2009 and 2011. Patients were inserted into four groups: A) biliopancreatic limb with 50 cm length and alimentary limb with 100 cm length; B) biliopancreatic limb with 50 cm length and alimentary limb with 150 cm length; C) biliopancreatic limb with 100 cm length and alimentary limb with 100 cm length; D) biliopancreatic limb with 100 cm length and alimentary limb with 150 cm length. Age, gender, body mass index and the percentage of total weight loss were analyzed. Data were collected preoperatively and one year after surgery. The groups were compared and weight loss compared between groups. RESULTS: The follow-up occurred in 78.3% of the sample. The composition of the groups was similar, with no statistical significance. The average age was 43 years in groups A, C and D and 42 years in group B. The female gender predominated in all groups (about 60% of the sample). The mean body mass index was 46 kg/m2 for groups A, C and D and 42 kg/m2 in group B. The percentage of weight loss was 33% for group A and 34% for groups B, C and D. There was no significant difference among groups. CONCLUSION: Different lengths of the biliopancreatic and alimentary limbs did not affect the percentage of total weight loss.

Roux-en-Y gastric bypass: limb length and weight loss / Derivação gástrica em Y-de-Roux: comprimento das alças e emagrecimento

BACKGROUND: Roux-en-Y gastric bypass is a surgical technique widely used in the treatment of obesity. It is unclear, however, if the length of the biliopancreatic and alimentary limb interferes with the magnitude of weight loss. AIM: To evaluate if the length of these limbs is related to the percentage of weight loss one year after surgery. METHOD: One hundred and twenty obese people underwent surgery between 2009 and 2011. Patients were inserted into four groups: A) biliopancreatic limb with 50 cm length and alimentary limb with100 cm length; B) biliopancreatic limb with 50 cm length and alimentary limb with 150 cm length; C) biliopancreatic limb with 100 cm length and alimentary limb with100 cm length; D) biliopancreatic limb with 100 cm length and alimentary limb with150 cm length. Age, gender, body mass index and the percentage of total weight loss were analyzed. Data were collected preoperatively and one year after surgery. The groups were compared and weight loss compared between groups. RESULTS: The follow-up occurred in 78.3% of the sample. The composition of the groups was similar, with no statistical significance. The average age was 43 years in groups A, C and D and 42 years in group B. The female gender predominated in all groups (about 60% of the sample). The mean body mass index was 46 kg/m2 for groups A, C and D and 42 kg/m2 in group B. The percentage of weight loss was 33% for group A and 34% for groups B, C and D. There was no significant difference among groups. CONCLUSION: Different lengths of the biliopancreatic and alimentary limbs did not affect the percentage of total weight loss. .

RACIONAL: A derivação gástrica em Y-de-Roux é técnica cirúrgica amplamente empregada no tratamento da obesidade. Não está claro, porém, se o comprimento das alças biliopancreática e alimentar interfere na magnitude da perda de peso. OBJETIVO: Avaliar se o comprimento dessas alças tem relação com a percentagem de perda de peso, um ano após a operação. MÉTODO: Cento e vinte obesos foram submetidos à cirurgia entre 2009 e 2011. Eles foram inseridos, por sorteio, em qautro grupos: A) alça biliopancreática de 50 cm e alimentar de 100 cm; B) alça biliopancreática de 50 cm e alimentar de 150 cm; C) alça biliopancreática de 100 cm e alimentar de 100 cm; e D) alça biliopancreática de 100 cm e alimentar de 150 cm. Analisou-se a idade, o gênero, o índice de massa corpórea e a percentagem de perda do peso total. Os dados foram coletados no pré-operatório e um ano após a operação. Os grupos foram comparados entre si e a perda ponderal comparada entre os grupos. RESULTADOS: O acompanhamento ocorreu em 78,3% da casuística. A composição dos grupos foi semelhante, sem significância estatística. A média de idade foi de 43 anos nos grupos A, C e D e de 42 no grupo B. O gênero feminino predominou em todos os grupos (cerca de 60% da amostra). O índice de massa corpóreo médio foi de 46 kg/m2 para os grupos A, C e D e de 42 kg/m2no grupo B. A percentagem de perda de peso foi de 33% para o grupo A e de 34% para os grupos B, C e D. Sem diferença significante entre os grupos. CONCLUSÃO: Diferentes comprimentos das alças biliopancreática e alimentar não interferiram na percentagem de perda do peso total. .

[Esophageal motility, symptoms, food intake and weight loss after Roux-en-Y gastric bypass]. / Motilidade esofágica, sintomas, resultado alimentar e perda de peso após derivação gástrica em Y-de-Roux.

BACKGROUND: Abnormal manometry findings can be found in the obese population. It is controversial if the manometry should be used to choose the adequate operation or if the motility status could predict symptomatic outcomes. AIM: To correlate the esophageal motility with postoperative symptoms, alimentary outcome and weight loss after Roux-en-Y gastric bypass. METHODS: One hundred and fourteen patients were submitted to the operation and were prospectively studied. They had no GERD symptoms or diseases that might interfere with esophageal motor function. One year after surgery patients were interviewed regarding current symptoms and eating habits. RESULTS: Excess weight loss was 66.2 %. Sixty (52.6%) patients had an abnormal manometry. Hypertensive lower esophageal sphincter was found in 18 (16%) patients and hypotonic sphincter in 31 (27%). Dumping syndrome was mentioned by 27 (23.6%) patients and 21 (18.4%) complained of regurgitation. Excellent, good, moderate and poor alimentary outcome was present in 32 (28%), 31 (27.2%), 39 (34.2%), 12 (11.6%) patients, respectively. Sphincter pressure and esophageal amplitude did not correlate with excess weight loss. Its average was significantly higher for patients with hypertensive esophageal amplitude. Regurgitation was more frequent in patients with a hypotensive sphincter. There is no correlation between dumping and sphincter pressure status; between dumping or regurgitation and esophageal amplitude; between alimentary outcomes and sphincter pressure status or esophageal amplitude. CONCLUSION: Esophageal manometry before Roux-en-Y gastric bypass is of limited clinical significance.

Motilidade esofágica, sintomas, resultado alimentar e perda de peso após derivação gástrica em Y-de-Roux / Esophageal motility, symptoms, food intake and weight loss after Roux-en-Y gastric bypass

RACIONAL: Achados anormais de manometria podem ser encontrados na população obesa. É controverso se a manometria deveria ser usada para escolher a técnica cirúrgica e se a função esofágica poderia prever os sintomas pós-operatórios. OBJETIVO: Correlacionar a motilidade do esôfago com sintomas pós-operatórios, resultado alimentar e perda de peso após a derivação gástrica em Y de Roux. MÉTODO: Cento e catorze pacientes submetidos à derivação foram estudados prospectivamente. Eles não apresentavam sintomas de refluxo gastroesofágico ou doenças que pudessem interferir com a função motora do esôfago. Um ano após a operação foram entrevistados sobre os sintomas e hábitos alimentares. RESULTADOS: A perda do excesso de peso foi de 66,2%. Sessenta pacientes (52,6%) tiveram manometria anormal; quarenta e nove (43%) alterações manométricas no esfíncter inferior do esôfago no pré-operatório; pressão elevada em 18 pacientes (16%) e baixa em 31 (27%). A síndrome de dumping foi encontrada em 27 (23,6%) pacientes e 21 (18,4%) queixaram-se de regurgitação. Resultado alimentar excelente, bom, moderado e pobre esteve presente em 32 (28%), 31 (27,2%), 39 (34,2%), 12 (11,6%) pacientes, respectivamente. A pressão do esfíncter inferior e amplitude de contração do esôfago não se correlacionam com perda do excesso de peso, cuja média foi significativamente maior para os pacientes com hipertensão na amplitude de contração. Regurgitação foi mais frequente em pacientes com hipotonia do esfíncter. Não houve correlação entre dumping e pressão do esfíncter inferior; entre amplitude de contração e dumping ou regurgitação; entre os resultados alimentares e pressão do esfíncter ou amplitude de contração do esôfago. CONCLUSÃO: A manometria esofágica antes da derivação é de importância clínica limitada.

BACKGROUND: Abnormal manometry findings can be found in the obese population. It is controversial if the manometry should be used to choose the adequate operation or if the motility status could predict symptomatic outcomes. AIM: To correlate the esophageal motility with postoperative symptoms, alimentary outcome and weight loss after Roux-en-Y gastric bypass. METHODS: One hundred and fourteen patients were submitted to the operation and were prospectively studied. They had no GERD symptoms or diseases that might interfere with esophageal motor function. One year after surgery patients were interviewed regarding current symptoms and eating habits. RESULTS: Excess weight loss was 66.2 %. Sixty (52.6%) patients had an abnormal manometry. Hypertensive lower esophageal sphincter was found in 18 (16%) patients and hypotonic sphincter in 31 (27%). Dumping syndrome was mentioned by 27 (23.6%) patients and 21 (18.4%) complained of regurgitation. Excellent, good, moderate and poor alimentary outcome was present in 32 (28%), 31 (27.2%), 39 (34.2%), 12 (11.6%) patients, respectively. Sphincter pressure and esophageal amplitude did not correlate with excess weight loss. Its average was significantly higher for patients with hypertensive esophageal amplitude. Regurgitation was more frequent in patients with a hypotensive sphincter. There is no correlation between dumping and sphincter pressure status; between dumping or regurgitation and esophageal amplitude; between alimentary outcomes and sphincter pressure status or esophageal amplitude. CONCLUSION: Esophageal manometry before Roux-en-Y gastric bypass is of limited clinical significance.

Endoscopic findings of asymptomatic patients one year after Roux-en-Y gastric bypass for treatment of obesity.

BACKGROUND: In the late post-operative period, the necessity of performing an upper gastrointestinal endoscopy (GIE) to check for complications is controversial. Some authors suggest it should be routine for all patients, others selectively, but not all patients with endoscopic abnormalities are symptomatic and some abnormalities are potentially severe. The study was conducted to evaluate the endoscopic findings from asymptomatic obese patients after Roux-en-Y gastric bypass (RYGB) and correlate them with the demographic data and the presence of Helicobacter pylori (Hp). METHODS: A total of 715 asymptomatic patients were prospectively submitted to an upper GIE at the end of their first post-operative year. These examinations were evaluated for the presence of abnormalities, their prevalence and their potential severity. RESULTS: Abnormalities were found in 189 patients (26.5 %). Eighty-four (11.7 %) presented esophageal abnormalities, with 72 (10.1 %) characterized as esophagitis and 12 (1.7 %) as hiatal hernia. Forty-five patients (6.3 %) presented abnormalities of the stomach and the anastomosis, with 26 (3.6 %) characterized as anastomotic ulcers, nine (1.3 %) as stenosis of the gastrojejunal anastomosis, ten (1.4 %) as band erosion and 72 (10.1 %) as jejunitis. There was a statistically significant correlation between super obesity and band erosion. CONCLUSIONS: An upper GIE at the end of the first year of RYGB plays an important role, even for asymptomatic patients. One fourth of these asymptomatic patients had their treatment modified after the upper GIE was performed.

Weight loss outcome after Roux-en-Y gastric bypass: 10 years of follow-up.

BACKGROUND: By submitting obese people to surgical treatment, we hope they lose weight and stay slim. Long-term monitoring is essential to assess effectiveness of surgery. This study aims to evaluate weight loss over 10 years in an obese population undergoing banded Roux-en-Y gastric bypass (B-RYGBP). METHODS: The surgery was performed in 211 obese between May 1999 and December 2000. This prospective study evaluated excess weight loss (%EWL) and body mass index (BMI) during the period. We considered surgical treatment failure if %EWL was less than 50 %. RESULTS: We followed 54.9 % of the population (116 patients). Patients' %EWL was 67.6 ± 14.9 % 1 year after surgery, 72.6 ± 14.9 % after 2 years, 69.7 ± 15.1 % after 5 years, 66.8 ± 7.6 % after 8 years, and 67.1 ± 11.9 % after 10 years postoperatively. Surgical treatment failure occurred in 16 patients (14.6 %) over 10 years. CONCLUSIONS: B-RYGBP is a good technique to promote and maintain weight loss 10 years after surgery with low failure rate.

Urinary evaluation after RYGBP: a lithogenic profile with early postoperative increase in the incidence of urolithiasis.

BACKGROUND: The objective of this study was to assess predictors for new-onset stone formers after Roux-en-Y gastric bypass (RYGBP). METHODS: One hundred and fifty-one obese patients underwent RYGBP and were followed for 1 year. The analysis comprised two study time points: preoperative (T0) and 1 year after surgery (T1). They were analyzed for urinary stones, blood tests, and 24-h urinary evaluation. Nonparametric tests, logistic regression, and multivariate analysis were conducted using SPSS 17. RESULTS: Median BMI decreased from 44.1 to 27.0 kg/m2 (p < 0.001) in the postoperative period. Urinary oxalate (24 versus 41 mg; p < 0.001) and urinary uric acid (545 versus 645 mg; p < 0.001) increased significantly postoperatively (preoperative versus postoperative, respectively). Urinary volume (1310 versus 930 ml; p < 0.001), pH (6.3 versus 6.2; p = 0.019), citrate (268 versus 170 mg; p < 0.001), calcium (195 versus 105 mg; p < 0.001), and magnesium (130 versus 95 mg; p = 0.004) decreased significantly postoperatively (preoperative versus postoperative, respectively). Stone formers increased from 16 (10.6 %) to 27 (17.8%) patients in the postoperative analysis (p = 0.001). Predictors for new stone formers after RYGBP were postoperative urinary oxalate (p = 0.015) and uric acid (p = 0.044). CONCLUSIONS: RYGBP determined profound changes in urinary composition which predisposed to a lithogenic profile. The prevalence of urinary lithiasis increased almost 70% in the postoperative period. Postoperative urinary oxalate and uric acid were the only predictors for new stone formers.

Esophageal motility after laparoscopic Roux-en-Y gastric bypass: the manometry should be preoperative examination routine?

BACKGROUND: Our goal was to identify the changes of esophageal motility, lower esophageal sphincter (LES) function, and eating adaptation before and after Roux-en-Y gastric bypass (RYGBP) and whether manometry should be a routine examination in patients who undergo this procedure. METHODS: A total of 81 patients underwent manometry before surgery and 1 year after surgery. The control group consisted of 10 nonobese volunteers. Patients were classified as presenting with vomiting and without vomiting 1 year after surgery. Manometric variables were compared before and after surgery. Statistical analysis was performed using Wilcoxon and Mann-Whitney test. RESULTS: The patients (45.6%) had preoperative manometric findings, 29.8% had LES hypertonia, 18.9% LES hypotonia, 43.2% increase in wave amplitude of contraction, and three 8.1% abnormal peristalsis. One year after surgery manometry was abnormal in 62.9% of patients, 11.7% with hypertonia and 15.7% with hypotonia of the LES, 53% with changes in amplitude contraction and 19.6% with abnormal peristalsis. The control group showed no manometric abnormalities. Chronic vomiting was noted in 21% of patients. When comparing all variables between the pre and postoperative periods, there was no significant difference for all of them except for peristalsis. Comparing the results of manometric findings between the vomiting and non-vomiting groups, no significant changes were found in the variables studied. CONCLUSIONS: There was an association between RYGBP and motor abnormalities in the esophagus but no differences in postoperative feeding adaptation. Thus, we conclude that esophageal manometry is not necessary as a routine preoperative examination.

Weight loss eight years after gastric bypass.

OBJECTIVE: To evaluate the effectiveness of banded Roux-en-Y gastric bypass in promoting weight loss after an eight-year follow-up. METHODS: Two hundred and eleven obese patients underwent Roux-en-Y gastric bypass with banding by the same surgical team. The study design was longitudinal, prospective and descriptive. The analysis of weight decrease in the postoperative period was based on the loss of excess weight in percentage and BMI. Failure was considered when patients lost <50% of excess weight. RESULTS: The loss of follow-up was 36.5%, therefore, 134 patients were included in this study. The loss of excess weight in global average rate in the postoperative period was: 67.6 ± 14.9% in the first year, 72.6 ± 14.9% in the second year, 69.7 ± 15.1% in fifth year and 66.8 ± 7.6 in eight years. Surgical treatment failure occurred in 15 patients (7.1%) over the period. CONCLUSION: Banded Roux-en-Y gastric bypass was effective in promoting and sustaining weight loss in the long term, with low failure rates.

Evolução ponderal oito anos após a derivação gástrica em Y-de-Roux / Weight loss eight years after gastric bypass

OBJETIVO: Avaliar a eficácia da derivação gástrica com bandagem em Y-de-Roux na promoção da perda de peso após oito anos de seguimento. MÉTODOS: Duzentos e onze obesos foram submetidos à derivação gástrica com bandagem em Y-de-Roux, pela mesma equipe cirúrgica. O desenho do estudo foi longitudinal, prospectivo e descritivo. A análise da diminuição do peso no pós-operatório foi baseado na perda do excesso de peso em percentual e no cálculo do IMC. Falha terapêutica foi considerada quando os pacientes perderam <50 por cento do excesso de peso. RESULTADOS: A perda de seguimento foi de 36,5 por cento, portanto, 134 pacientes foram incluídos neste estudo. A perda do excesso de peso em percentual média global no pós-operatório foi de: 67,6 ± 14,9 por cento no primeiro ano, 72,6 ± 14,9 por cento no segundo ano, 69,7 ± 15,1 por cento no quinto ano e 66,8 ± 7,6 em oito anos. Falha no tratamento cirúrgico ocorreu em 15 pacientes (7,1 por cento) ao longo dos oito anos. CONCLUSÃO: A derivação gástrica com bandagem em Y-de-Roux foi efetiva na promoção e manutenção da perda de peso no longo prazo, com baixa taxa de falhas.

OBJECTIVE: To evaluate the effectiveness of banded Roux-en-Y gastric bypass in promoting weight loss after an eight-year follow-up. METHODS: Two hundred and eleven obese patients underwent Roux-en-Y gastric bypass with banding by the same surgical team. The study design was longitudinal, prospective and descriptive. The analysis of weight decrease in the postoperative period was based on the loss of excess weight in percentage and BMI. Failure was considered when patients lost <50 percent of excess weight. RESULTS: The loss of follow-up was 36.5 percent, therefore, 134 patients were included in this study. The loss of excess weight in global average rate in the postoperative period was: 67.6 ± 14.9 percent in the first year, 72.6 ± 14.9 percent in the second year, 69.7 ± 15.1 percent in fifth year and 66.8 ± 7.6 in eight years. Surgical treatment failure occurred in 15 patients (7.1 percent) over the period. CONCLUSION: Banded Roux-en-Y gastric bypass was effective in promoting and sustaining weight loss in the long term, with low failure rates.

Roux-en-Y gastric bypass and inflammatory activity of the adipose tissue.

OBJECTIVE: To evaluate the oxidative stress and inflammatory markers in obese patients before and after Roux-en-Y vertical banded gastroplasty. METHODS: We studied 20 class III obese patients undergoing Roux-en-Y vertical banded gastroplasty, seven men and 13 women, mean age 39 years, and 20 non-obese subjects, nine males and 11 females, mean age 38 years. We determined the plasma levels of malondialdehyde, stress an index, total antioxidant capacity, catalase, reduced and oxidized glutathione and inflammatory markers (C reactive protein and á-1 acid glycoprotein). In the obese group, these parameters were determined before and 2, 6 and 12 months after gastroplasty. RESULTS: Preoperatively, the obese group showed elevated levels of inflammatory markers of oxidative stress (malondialdehyde levels and stress index) and lower levels of indicators of antioxidant defense compared to the control group. Weight loss was accompanied by gradual reduction in the levels of malondialdehyde and stress index. We found an increased concentration of reduced glutathione and total antioxidant status and reduced levels of inflammatory markers. CONCLUSION: Weight loss improves the inflammatory state and oxidative stress levels.

Emagrecimento e desempenho cardíaco / Weight loss and cardiac performance

RACIONAL: As doenças cardiovasculares representam as complicações mais frequentemente associadas à obesidade. O emagrecimento determina diminuição da pressão arterial e melhora nos parâmetros dos lipídeos e glicose séricos. A perda de peso e sua manutenção reduzem os fatores de risco para doenças cardiovasculares, tornando, reversíveis as alterações cardíacas decorrentes da obesidade. OBJETIVO: Avaliar o efeito da perda de peso sobre a capacidade física e as alterações estruturais e funcionais do coração de obesos submetidos à procedimento cirúrgico bariátrico. MÉTODOS: Quarenta e três pacientes submetidos à derivação gástrica em Y-de-Roux, foram analisados por eletrocardiograma, teste ergométrico e ecodopplercardiograma no pré-operatório e um ano após a derivação. Na análise estatística utilizaram-se os testes de Wilcoxon, t de Student, Shapiro-Wilk com nível de significância de 5 por cento. RESULTADOS: O peso diminuiu de 116,5 kg ± 21,5 para 80 kg ± 15,9; o IMC de 41,8kg/m2 ± 4,4 para 28,4kg/m2 ± 3,8; a frequência cardíaca reduziu de 77,9 bpm ± 9,6 para 70,9bpm ± 7,8; a pressão sistólica de 130 mmHg ± 20 para 120mmHg ± 10; a diastólica de 80 mmHg ± 10 para 80 mmHg ± 0. O teste ergométrico mostrou aumentos na distância percorrida de 378,9m ± 126,5m para 595m ± 140,4; no coeficiente metabólico (MET) de 6,7 ± 2,4 ml de O2/kg/min para 8,3 ± 2,6ml de O2/kg/min; no consumo de oxigênio (VO2) de 23,1 ± 8,4 para 30 ± 10,3. O ecodopplercardiograma mostrou redução no septo interventricular de 12 mm ± 2 para 10 mm ± 1; parede posterior de 11 mm ± 2 para 10 mm ± 1; massa ventricular de 273 g ± 85 para 216g ± 60. Houve melhora na função diastólica com aumento na relação E'/A'e E/A e da fração de ejeção com elevação de 70,2 por cento ± 7,2 para 72,9 por cento ± 6,4. CONCLUSÃO: Obesos submetidos à cirurgia bariátrica apresentaram melhora na capacidade física e melhora estrutural e funcional do coração.

BACKGROUND: Cardiovascular diseases are the most frequent complications associated with obesity. The weight loss determine blood pressure decrease and improvement in parameters of lipid and glucose levels. Weight loss and maintenance reduce the risk factors for cardiovascular disease, making reversible cardiac changes resulting from obesity. AIM: To evaluate the effect of weight loss on physical capacity and the structural and functional heart of obese patients undergoing to bariatric surgery. METHODS: Forty-three patients who underwent gastric Roux-en-Y bypass, were analyzed by ECG, and echocardiography preoperatively and one year after the bypass. Statistical analysis used the Wilcoxon and Student t test, Shapiro-Wilk test with a significance level of 5 percent. RESULTS: The weight decreased from 116.5 kg to 21.5 ± 15.9 ± 80 kg, BMI of 41.8 kg/m 2 ± 4.4 to 28.4 kg/m 2 ± 3.8, heart rate decreased from 77.9 ± 9.6 bpm to 70.9 ± 7.8 bpm, systolic pressure of 130 ± 20 mmHg to 120 mmHg ± 10, diastolic 80 mmHg ± 10 mmHg to 80 ± 0. The exercise test showed increases in distance traveled of 378.9 m ± ​​126.5 m to 140.4 ± 595m; coefficient in metabolic equivalents (METs) from 6.7 ± 2.4 ml O 2 / kg / min to 8.3 ± 2.6 ml O 2 / kg / min, oxygen consumption (VO 2) 23.1 ± 8.4 to 10.3 ± 30. The echocardiogram showed a reduction in the interventricular septum of 12 mm to 10 mm ± 2 ± 1; posterior wall of 11 mm to 10 mm ± 2 ± 1; ventricular mass of 273 ± 85 g to 216g ± 60. There was improvement in diastolic function with increase in E '/ A'e E / A and ejection fraction with an increase of 70.2 percent ± 7.2 to 72.9 ± 6.4 percent. CONCLUSION: Obese patients undergoing bariatric surgery showed improvement in physical capacity and in the structure/functioning of the heart.