RESUMO
A young, previously healthy woman developed bilateral exudative tonsillitis that was associated with severe systemic symptoms. This was followed by evidence of multisystem disease with acute abdominal pain, raised liver enzyme levels, respiratory difficulty, increasing drowsiness and multiple vesicular skin lesions. Herpes simplex virus type-1 was isolated from skin lesions and a throat swab and herpes simplex virus type-1 antigen was detected in a liver biopsy sample. She recovered rapidly without any sequelae after treatment with intravenously administered acyclovir.
Assuntos
Herpes Simples/imunologia , Dor Abdominal/etiologia , Aciclovir/uso terapêutico , Adulto , Feminino , Hepatite Viral Humana/etiologia , Hepatite Viral Humana/microbiologia , Hepatite Viral Humana/patologia , Herpes Simples/complicações , Herpes Simples/tratamento farmacológico , Herpes Simples/patologia , Humanos , Tolerância ImunológicaRESUMO
New observations are described in a case of congenital hepatic fibrosis. Histochemical stains of liver tissue for copper (rhodanine) and copper associated protein (orcein) were positive and hepatic copper concentration, measured by atomic absorption spectroscopy, was markedly elevated being 550 micrograms/g dry weight (NR less than 30 micrograms/g dry weight). Mallory bodies were observed in several areas in liver sections. These observations have not been previously recorded in congenital hepatic fibrosis. Increased hepatic copper concentration in this case may have contributed to the production of liver damage. Hepatic copper concentration should be specifically measured in other patients with congenital hepatic fibrosis.
Assuntos
Cobre/metabolismo , Hepatopatias/congênito , Fígado/ultraestrutura , Adulto , Retículo Endoplasmático/ultraestrutura , Humanos , Hepatopatias/metabolismo , Hepatopatias/patologia , MasculinoRESUMO
Exfoliative, abrasive and aspiration cytology were increasingly relied upon for tissue diagnosis of tumours. The established histological stains for the differentiation of mucin and non-mucin-secreting tumours are not ideal for alcohol-fixed cytology smears and a more reliable cytological technique for the preservation and staining of intra-cellular acidic mucins using Alcohol Alcian Blue 8GX is presented.
Assuntos
Citodiagnóstico/métodos , Mucinas/análise , Técnicas Histológicas , Humanos , Neoplasias/análise , Coloração e RotulagemRESUMO
A 34 year old female developed impaired function of her renal allograft 21 months post-transplant. This was associated with lethargy, pyrexia, tenosynovitis, pancytopenia and a colonic ulcer. Severe tubulo-interstitial changes with intranuclear inclusion bodies and intracytoplasmic herpes type viral particles were seen on renal biopsy. There was no evidence of rejection. Cytomegalovirus was cultured from the urine and there was a rise in CMV antibody titer. These findings suggested the renal impairment was due to a direct cytopathic effect of the CMV. Despite treatment with transfer factor and adenine arabinoside, there was progressive loss of graft function.
Assuntos
Infecções por Citomegalovirus/patologia , Transplante de Rim , Nefrite Intersticial/patologia , Adulto , Anticorpos Antivirais/imunologia , Citomegalovirus/isolamento & purificação , Infecções por Citomegalovirus/imunologia , Feminino , HumanosRESUMO
This study was undertaken to assess the frequency of development and the stages of evolution of chronic liver disease in patients with renal failure who are chronic carriers of hepatitis B surface antigen. Cirrhosis or chronic active hepatitis developed in five of 21 patients and could not be predicted by the initial histological appearance or by HLA-A and B typing but was associated with the e antigen in four of the five patients. However, the antigen was not a consistent indicator of a poor prognosis, as the four other e antigen positive patients did not develop chronic liver disease during the period of the study. Transmission of hepatitis B to spouses occurred in four cases, was fatal in one instance, and was associated with e antigen in three of the four. Determination of e antigen status in renal unit patients who are carriers of hepatitis B surface antigen may be of value to the patient and his home environment.
Assuntos
Portador Sadio/imunologia , Antígenos da Hepatite B/imunologia , Antígenos de Superfície da Hepatite B/imunologia , Falência Renal Crônica/imunologia , Hepatopatias/imunologia , Doença Aguda , Doença Crônica , Feminino , Hepatite/imunologia , Hepatite/patologia , Hepatite B/imunologia , Hepatite B/transmissão , Humanos , Falência Renal Crônica/complicações , Hepatopatias/etiologia , Masculino , PrognósticoRESUMO
A patient who manifested both pulmonary and hepatic disease associated with alpha1-antitrypsin deficiency is described. The biological function of alpha1-antitrypsin is discussed, as well as the inheritance of deficiency states and the spectrum of disorders which may ensue. Severe deficiency of alpha1-antitrypsin has been linked with pulmonary emphysema in adult life, progressive liver disease in childhood, adult cirrhosis but rarely with both pulmonary and liver disease.