1.
Org Biomol Chem
; 15(37): 7758-7764, 2017 Sep 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28891572
RESUMO
Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.