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Eur J Clin Nutr ; 54(11): 840-3, 2000 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11114678

RESUMO

OBJECTIVE: To evaluate alpha-linolenic acid (ALA) (18∶3 n-3) and linolenic acid (LA) (18∶2 n-6) in cholesterol esters (CE) as markers of ALA and LA dietary intakes in preterm infants. SUBJECTS: Forty-five preterm infants: two groups fed different formulas, the third fed human milk. DESIGN: ALA and LA dietary intakes were precisely recorded in each infant to accurately determine the cumulative amount of ingested ALA and LA during two intervals: (i) between the second day after the first significant formula intake (D0) and the fifteenth day (D15); and (ii) between D0 and the first day of the 37th week of post-conception age (W37). The corresponding amounts of ingested ALA and LA were related to ALA and LA levels determined by capillary column gas-liquid chromatography in plasma cholesterol esters at D15 and W37, respectively. RESULTS: ALA in CE was very significantly correlated to D0-D15 and D0-W37 ALA intakes (0.66; P=0.0001 and 0.70; P=0.0001), respectively. LA in CE was weakly correlated to D0-D15 LA intakes (0.03; P=0.01) and whatever the group (human milk or enriched formula) the correlation was lost at W37. CONCLUSION: In preterm infants, ALA in CE can be considered as representative of ALA dietary intakes, whereas LA in CE appears as a poor marker of LA intakes.


Assuntos
Ésteres do Colesterol/química , Alimentos Infantis , Recém-Nascido Prematuro/metabolismo , Ácido alfa-Linolênico/administração & dosagem , Disponibilidade Biológica , Biomarcadores/análise , Ésteres do Colesterol/sangue , Cromatografia Gasosa , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Recém-Nascido Prematuro/sangue , Masculino , Leite Humano , Estatística como Assunto , Ácido alfa-Linolênico/análise , Ácido alfa-Linolênico/metabolismo
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