RESUMO
The phytochemical study of stem bark of Allanblackia gabonensis has resulted in the isolation and characterisation of one new xanthone derivative, named allanxanthone D, together with 10 known compounds, including 6 xanthones derivatives, allanxanthone A, 1,5-dihydroxyxanthone, 1,7-dihydroxyxanthone and 1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)xanthone, forbexanthone, 6-deoxyisojacareubin, one polyisoprenylated benzophenone, guttiferone F, one flavanol, epicathechin, two phytosterols, beta-sitosterol and campesterol. The structures of these compounds were established on the basis of one- and two-dimensional NMR homo- and hetero-nuclear evidence. These compounds were evaluated for their activity against Leishmania amazonensis in vitro and antimicrobial activities against a range of Gram negative and Gram positive bacteria.
Assuntos
Antibacterianos/química , Antifúngicos/química , Antiprotozoários/química , Clusiaceae/química , Animais , Antibacterianos/farmacologia , Antiprotozoários/farmacologia , Bactérias/efeitos dos fármacos , Leishmania/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Estrutura Molecular , Casca de Planta/química , Caules de Planta/químicaRESUMO
A cacalolide derivative named 4alpha-[2'-hydroxymethylacryloxy]-1beta-hydroxy-14-(5-->6) abeo eremophilan-12,8-olide and a shikimic acid derivative named (3'E)-(1alpha)-3-hydroxymethyl-4beta,5alpha-dimethoxycyclohex-2-enyloctadec-3'-enoate along with three known compounds, octacosan-1-ol, 3beta-hydroxyolean-12-en-28-oic acid and 3beta-acetoxyolean-12-en-28-oic acid were isolated from Senecio burtonii. Their structures and relative configurations were established on the basis of spectroscopic analysis.
Assuntos
Naftalenos/isolamento & purificação , Senécio/química , Ácido Chiquímico/análogos & derivados , Estrutura Molecular , Naftalenos/química , Estruturas Vegetais/química , Ácido Chiquímico/química , Ácido Chiquímico/isolamento & purificaçãoRESUMO
In addition to one known compound, 3beta,8alpha-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (8-desacylcynaropicrin) (3), two new sesquiterpene lactones have been isolated from the aerial parts of Crepis cameroonica. By means of spectroscopic analysis, the structures and relative configurations of the new compounds were established as 3beta,9beta-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (1) and 8alpha-hydroxy-4alpha(13),11beta(15)-tetrahydrozaluzanin C (2). The in vitro antimicrobial spectrum of pure compounds and crude extracts are also reported.
Assuntos
Antibacterianos/farmacologia , Crepis , Fitoterapia , Extratos Vegetais/farmacologia , Antibacterianos/administração & dosagem , Antibacterianos/química , Antibacterianos/uso terapêutico , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Humanos , Lactonas/administração & dosagem , Lactonas/química , Lactonas/farmacologia , Lactonas/uso terapêutico , Testes de Sensibilidade Microbiana , Componentes Aéreos da Planta , Extratos Vegetais/administração & dosagem , Extratos Vegetais/química , Extratos Vegetais/uso terapêutico , Sesquiterpenos/administração & dosagem , Sesquiterpenos/química , Sesquiterpenos/farmacologia , Sesquiterpenos/uso terapêuticoRESUMO
From the methanol extract of the stem bark of Scaphopetalum thonneri, two new compounds, including one lignan, named scaphopetalone, one new ester of ferulic acid, named scaphopetalumate were isolated together with three known compounds including: two coumarins (scopoletin and scopolin), and one pentacyclic triterpene (oleanolic acid). The structure of the new compounds were elucidated by means of spectroscopic analyses.
Assuntos
Ácidos Cumáricos/isolamento & purificação , Guaiacol/isolamento & purificação , Malvaceae/química , Ácido Oleanólico/isolamento & purificação , Tetra-Hidronaftalenos/isolamento & purificação , Triterpenos/isolamento & purificação , Camarões , Ácidos Cumáricos/química , Ésteres , Guaiacol/análogos & derivados , Guaiacol/química , Lignanas , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Ácido Oleanólico/análogos & derivados , Ácido Oleanólico/química , Casca de Planta/química , Tetra-Hidronaftalenos/química , Triterpenos/químicaRESUMO
One new diterpenoid, methyl 3alpha-hydroxy-7-oxo-dehydroabietate (1), two new limonoids, 3alpha-deacetyl-amoorastatin (2) and 9beta-amoorastatin (3), and the known limonoid amoorastatin (4) were isolated from the stem of Pterorhachis zenkeri.
Assuntos
Abietanos , Diterpenos/isolamento & purificação , Flavonoides/isolamento & purificação , Limoninas , Plantas Medicinais , Rosales , Triterpenos/isolamento & purificação , Diterpenos/química , Flavonoides/química , Humanos , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Caules de Planta , Triterpenos/químicaRESUMO
Bioassay-directed fractionation of a methylene chloride extract of the root bark of Erythrina eriotricha resulted in the isolation of a novel isoflavanone, named eriotrichin B, and the five known pterocarpans, isonorautenol, erybraedin A, erybraedin C, erybraedin D and erybraedin E. The structure of the new compound has been investigated by extensive spectroscopic studies, including 2D NMR and chemical evidence. The in vitro antimicrobial spectrum and potencies of the isolated compounds are also reported.
Assuntos
Antibacterianos/química , Benzofuranos/química , Erythrina , Isoflavonas/química , Plantas Medicinais , Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Benzofuranos/isolamento & purificação , Benzofuranos/farmacologia , Escherichia coli/efeitos dos fármacos , Escherichia coli/crescimento & desenvolvimento , Isoflavonas/isolamento & purificação , Isoflavonas/farmacologia , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Cloreto de Metileno , Testes de Sensibilidade Microbiana , Estrutura Molecular , Extratos Vegetais , Raízes de Plantas , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus aureus/crescimento & desenvolvimentoRESUMO
In addition to the two known compounds neotautenol [2] and erythrinassinate B [4], two new compounds, an isoflavanone named sigmoidin J [1] and a coumestan derivative named sigmoidin K [3], have been isolated and characterized from the root bark of the Cameroonian medicinal plant Erythrina sigmoidea. Their structures have been established as 7, 4'-dihydroxy-2',5'-dimethoxy-6'(gamma, gamma-dimethylally)isoflavanone [1] and 3,9-dihydroxy-2,10-(gamma, gamma dimethylallyl) coumestan [3], respectively, by spectroscopic techniques and from chemical evidence.