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1.
Sensors (Basel) ; 24(2)2024 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-38257629

RESUMO

This article presents an open-source device illustrating the well-known magnetic levitation experiment. The uniqueness of this particular device lies in its exceptionally small dimensions, affordability and availability, which makes it a perfect design for take-home experiments for education but it can also serve as a referential design for testing various control algorithms in research. In addition, this paper provides a comprehensive hardware design for reproducibility along with the detailed derivation of the mathematical model, system identification and validation. Moreover, the introduced hardware comes with an easy-to-use open-source application programming interface in C/C++ for the Arduino IDE, Simulink and CircuitPython. REXYGEN, another environment similar to Simulink, had also been used to demonstrate the capabilities of the MagnetoShield.

2.
Science ; 377(6606): 629-634, 2022 08 05.
Artigo em Inglês | MEDLINE | ID: mdl-35926014

RESUMO

Meiosis, at the transition between diploid and haploid life cycle phases, is accompanied by reprograming of cell division machinery and followed by a transition back to mitosis. We show that, in Arabidopsis, this transition is driven by inhibition of translation, achieved by a mechanism that involves processing bodies (P-bodies). During the second meiotic division, the meiosis-specific protein THREE-DIVISION MUTANT 1 (TDM1) is incorporated into P-bodies through interaction with SUPPRESSOR WITH MORPHOGENETIC EFFECTS ON GENITALIA 7 (SMG7). TDM1 attracts eIF4F, the main translation initiation complex, temporarily sequestering it in P-bodies and inhibiting translation. The failure of tdm1 mutants to terminate meiosis can be overcome by chemical inhibition of translation. We propose that TDM1-containing P-bodies down-regulate expression of meiotic transcripts to facilitate transition of cell fates to postmeiotic gametophyte differentiation.


Assuntos
Proteínas de Arabidopsis , Arabidopsis , Ciclinas , Meiose , Corpos de Processamento , Arabidopsis/citologia , Arabidopsis/genética , Proteínas de Arabidopsis/genética , Proteínas de Arabidopsis/metabolismo , Proteínas de Transporte/metabolismo , Diferenciação Celular , Ciclinas/genética , Ciclinas/metabolismo , Meiose/genética , Mitose , Corpos de Processamento/metabolismo , Biossíntese de Proteínas
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