Aloe vera Compositions Used for Medicinal Applications: A Patent Review (2013-till 2020).

BACKGROUND: Aloe vera is a plant traditionally used for medicinal purposes. It is also used as a cosmetic. Aloe vera gel/extract/juice is used in hair care, moisturizing, cleansing, and thickening agent in formulations. Aloe vera gel is rarely used for burns, wounds, infections, and gastric diseases. OBJECTIVES: To study the patents filed recently and understand the trend in the application of Aloe vera for therapeutic purposes. METHODS: This patent review focuses on granted patents during the year 2013 to 2020. The patents were analyzed, and their therapeutic use was studied to assess the recent trends in Aloe vera formulations. RESULTS: Most of the patents studied in this article are based on skincare products. Out of those, the maximum patents are on moisturizing compositions. Most of the patents are found in US jurisdiction and a few in Europe and China. As there are certain restrictions on patenting inventions related to composition and natural products in various jurisdictions, patents are only found in a few jurisdictions. CONCLUSION: The trend of the use of Aloe vera is still towards cosmetic products. Also, Aloe vera is used in oral care composition, deodorant compositions, anti-inflammatory composition, vitamin compositions, antibiotic compositions, etc.

Isatin Hybrids and Their Pharmacological Investigations.

Hybridization is an important strategy to design molecules that can be effectively used to treat fatal diseases known to mankind. Molecular hybrids and their pharmacological investigations aided in discovering several potent isatin (Indole 2, 3 dione) derivatives with anti-HIV, antimalarial, antitubercular, antibacterial, and anticancer activities. Indole-2,3-dione and their derivatives have diverse pharmacological properties and have a prominent role in the discovery of new drugs. To understand the various approaches for designing new molecules based on isatin nucleus analysis of various pharmacophore hybrids, spacers/linkers between pharmacophores and isatin for hybridization and their biological activities are important. This review discusses the progress in developing isatin hybrids as biologically effective agents and their crucial aspects of design and structure-activity relationships.