RESUMO
OBJECTIVES: Evaluate the 5-year safety and efficacy of a narrow-diameter (3.0 mm) implant that was immediately provisionalized with a single crown in the maxillary lateral incisor or mandibular central or lateral incisor area. MATERIALS AND METHODS: An open, prospective, single-cohort, multicenter study was conducted, in which narrow-diameter implants were placed in fresh, healed extraction, or congenitally missing sites. All patients were required to meet strict criteria for immediate loading. The primary endpoints were marginal bone levels (MBL) and MBL changes (MBLC) from implant placement to 5-year follow-up. Secondary endpoints included cumulative 5-year survival and success rates, soft tissue health, and esthetic parameters. RESULTS: A total of 91 implants were placed in 77 patients. The mean MBL remained stable from the 1-year (- 0.79 ± 0.73 mm, n = 75) to 5-year (- 0.74 ± 0.87 mm, n = 65) follow-up. A marginal bone gain of 0.11 ± 0.83 mm was observed from the 1-year to 5-year follow-up. The cumulative 5-year survival rate was 96.5%, and the cumulative 5-year success rate was 93%. The clinical parameters, including the modified plaque index, modified sulcus bleeding index, Jemt's papilla index, and pink esthetic score improved throughout the 5-year study. CONCLUSIONS: The study demonstrated that narrow-diameter implants represent a safe and predictable treatment option for subjects suitable for immediate loading and with limited bone volume or limited inter-dental space. CLINICAL RELEVANCE: Narrow-diameter implants with immediate provisionalization can be considered for use to restore missing or damaged teeth with predictable functional and esthetic outcomes. This trial was registered with ClinicalTrials.gov (NCT02184845).
Assuntos
Coroas , Planejamento de Prótese Dentária , Estética Dentária , Carga Imediata em Implante Dentário , Humanos , Estudos Prospectivos , Feminino , Masculino , Pessoa de Meia-Idade , Adulto , Resultado do Tratamento , Implantes Dentários para Um Único Dente , Incisivo , IdosoRESUMO
OBJECTIVES: This study aimed to assess levels of biomarkers associated with inflammation and tissue destruction in peri-implant crevicular fluid (PICF) of implants provided with customized or standard healing abutments during early implant healing. MATERIALS AND METHODS: Thirty implants were placed in 22 patients with partial posterior edentulism. Subsequently, test group implants (n=15) received one-piece titanium abutments that were fabricated using computer-aided design/computer-aided manufacturing (CAD/CAM). Control group implants (n=15) were provided with standard abutments. PICF collection and standardized periapical radiographs were carried out at suture removal one week later, following crown delivery after 3 months and at 6 months. Expression of C-reactive protein (CRP), interferon-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-1α, IL-1ß, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12A, IL-17A, macrophage inflammatory protein (MIP)-1α, matrix metalloproteinase (MMP)-13, osteopontin, osteoactivin, Receptor Activator of NF-κB (RANK), and TGF-ß were analyzed using a multiplex ELISA kit. RESULTS: Both groups showed a significant decrease in protein expression of CRP, IL-1ß, IL-6, IL-8, MIP-1α, osteopontin, osteoactivin, and TGF-ß, while MMP-13 levels increased during the observation period. A rise in OPG and RANK levels was detected among customized abutments. Expression of CRP was higher, whereas IL-1ß, IL-1α, and MIP-1α were decreased in control compared to test group implants after 6 months. Marginal bone loss did not depend on abutment modality. CONCLUSIONS: Both abutment types showed distinctive temporal expression of inflammatory biomarkers during 6 months following implant placement. TRIAL REGISTRATION: ISRCTN98477184, registration date 18/05/2022 CLINICAL RELEVANCE: Customized healing abutments exert similar effects on inflammation during early implant healing compared to standard healing abutments.
Assuntos
Implantes Dentários , Humanos , Quimiocina CCL3 , Osteopontina , Projetos Piloto , Interleucina-6 , Interleucina-8 , Fator de Necrose Tumoral alfa/análise , Inflamação , Interleucina-1alfa , Fator de Crescimento Transformador beta , Desenho Assistido por Computador , Dente Suporte , TitânioRESUMO
INTRODUCTION: The aim was to present a novel surgical technique using virtually preplanned 3-dimensional (3D)-printed templates for guided osteotomies. These were to ensure atraumatic uncovering of a severely impacted donor tooth including guided drilling of the recipient alveolus followed by a secure autotransplantation procedure. METHODS: This report presents an autotransplantation procedure of a 14-year-old patient with a severely impacted second premolar and extensive contact to the roots of the adjacent teeth and the inferior alveolar nerve. Autotransplantation of the impacted premolar was virtually performed using modified methods from guided implant surgery in order to prefabricate 3D-printed templates with the aid of a fully digital workflow. RESULTS: Satisfactory treatment could be achieved using surgical templates for guided osteotomies of the surgical access, guided drilling of the recipient site, and occlusal reference template ensuring autotransplantation in the appropriate 3D location of the graft. An atraumatic approach could be ensured with an extraoral time of 46 seconds by 1 fitting attempt; no injuries or altered sensation of the inferior alveolar nerve were present. A vital natural tooth could be observed. CONCLUSIONS: This innovative technique uses for the first time a fully implemented digital workflow for guided osteotomies, guided drilling, and guided autotransplantation of a severely impacted tooth. 3D-printed templates could ensure a guided atraumatic approach and facilitate highly complex treatments by virtually implementing recommended guidelines in future autotransplantations.
Assuntos
Cirurgia Assistida por Computador , Dente Impactado , Adolescente , Dente Pré-Molar/cirurgia , Tomografia Computadorizada de Feixe Cônico , Humanos , Osteotomia , Impressão Tridimensional , Dente Impactado/diagnóstico por imagem , Dente Impactado/cirurgia , Transplante AutólogoRESUMO
OBJECTIVES: The aim of this interim analysis of a 5-year prospective multicenter study is to evaluate clinical and radiological performance of immediately provisionalized 3.0-mm-diameter tapered implants. MATERIALS AND METHODS: Patients needing implant rehabilitation of maxillary lateral incisors or mandibular lateral and central incisors were treated with 3.0-mm-diameter implants placed in extraction or healed sites and immediately provisionalized. Clinical and radiographic examinations were performed at implant insertion, 6 months thereafter, and are ongoing. Marginal bone levels and changes, complications, the papilla, plaque, and bleeding indices, and the pink esthetic score (PES) were evaluated at each follow-up visit. RESULTS: Of 112 enrolled patients, 77 patients (91 implants) met the inclusion criteria. Seventy-one patients with 82 implants completed the 1-year follow-up. Three implants failed yielding a CSR of 96.7%. All failures occurred within the first 3 months after implant insertion. Marginal bone level changes from insertion to 6 months was - 0.57 ± 1.30 mm (n = 75) and from insertion to 12 months - 0.25 ± 1.38 mm (n = 72). Fifteen non-serious complications were recorded. Papilla index score and PES improved at the 1-year follow-up. Plaque formation and bleeding-on-probing showed no statistically significant differences between the 6-month and the 1-year visit. CONCLUSIONS: This 1-year analysis demonstrated high survival, stable bone levels, and healthy soft tissue with 3.0-mm-diameter implants. CLINICAL IMPLICATIONS: Narrow diameter implants are a safe and predictable treatment option in patients with limited bone volume and/or limited interdental space and eligible for immediate loading protocols.
Assuntos
Implantes Dentários para Um Único Dente , Estética Dentária , Carga Imediata em Implante Dentário/métodos , Adulto , Planejamento de Prótese Dentária , Falha de Restauração Dentária , Feminino , Humanos , Incisivo , Masculino , Complicações Pós-Operatórias , Estudos Prospectivos , Resultado do TratamentoRESUMO
PURPOSE: To evaluate the effect of repeat surgery on treatment time in the interdisciplinary management of impacted maxillary canines. MATERIAL AND METHODS: This retrospective cohort study enrolled patients referred for computed tomographic examination for impacted maxillary canines within a 5-year observational period. The occurrence of repeat surgery was analysed with regard to treatment time, canine location, and surgical exposure technique. RESULTS: A total of 55 patients with 79 impacted maxillary canines were analysed. Of those, 83.6% did not present with complications that would have prompted repeat surgery during their treatment. For patients requiring repeat surgery, time until clinically visible movement of the canine was significantly longer (p < 0.001), whereas time between initial movement and eruption into the oral cavity was significantly shorter (p < 0.001). Overall treatment time did not differ significantly (p = 0.13). An open surgical exposure technique was associated with a significantly lower occurrence of repeat surgeries (p = 0.03). Bilateral impaction of canines significantly prolonged overall treatment time (p = 0.01). CONCLUSIONS: In the event of initial treatment failure during the interdisciplinary management of impacted maxillary canines, repeat surgery should be considered, which has limited effect on overall treatment time. An open surgical exposure technique is preferable.
Assuntos
Dente Canino/cirurgia , Dente Impactado/cirurgia , Adolescente , Adulto , Criança , Terapia Combinada , Dente Canino/diagnóstico por imagem , Feminino , Humanos , Masculino , Maxila , Pessoa de Meia-Idade , Braquetes Ortodônticos , Equipe de Assistência ao Paciente , Reoperação , Estudos Retrospectivos , Fatores de Tempo , Tomografia Computadorizada por Raios X , Dente Impactado/diagnóstico por imagem , Dente Impactado/terapia , Adulto JovemRESUMO
BACKGROUND: The first year of prosthetic loading is crucial to peri-implant bone levels; however, contributing factors are yet barely understood. PURPOSE: The purpose of the study is to investigate the influence of patient-, implant-, and prosthetic-related parameters on marginal bone resorption in partially edentulous patients within the first year of prosthetic loading. MATERIALS AND METHODS: This retrospective multifactorial analysis involved the following influencing factors: patient gender and age, implant diameter, implant location and neck design, insertion torque, insertion depth, splinted versus single-tooth restorations, crown height space, and crown-to-implant ratio. RESULTS: Mean peri-implant bone resorption around 200 dental implants was 0.98 ± 0.76 mm and significantly correlated to higher implant insertion depth (p < .001), whereas no association to prosthetic parameters could be observed. CONCLUSIONS: Within the limits of the present analysis, it can be concluded that apical implant positioning may constitute a relevant determinant of early peri-implant bone resorption.
Assuntos
Reabsorção Óssea/fisiopatologia , Implantação Dentária Endóssea , Prótese Dentária Fixada por Implante , Adulto , Idoso , Coroas , Planejamento de Prótese Dentária , Falha de Restauração Dentária , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Resultado do TratamentoRESUMO
PURPOSE: The study aims to evaluate the accuracy of the NobelGuide™ (Medicim/Nobel Biocare, Göteborg, Sweden) concept maximally reducing the influence of clinical and surgical parameters. Moreover, the study was to compare and validate two validation procedures versus a reference method. MATERIAL AND METHODS: Overall, 60 implants were placed in 10 artificial edentulous mandibles according to the NobelGuide™ protocol. For merging the pre- and postoperative DICOM data sets, three different fusion methods (Triple Scan Technique, NobelGuide™ Validation software, and AMIRA® software [VSG - Visualization Sciences Group, Burlington, MA, USA] as reference) were applied. Discrepancies between the virtual and the actual implant positions were measured. RESULTS: The mean deviations measured with AMIRA® were 0.49 mm (implant shoulder), 0.69 mm (implant apex), and 1.98°mm (implant axis). The Triple Scan Technique as well as the NobelGuide™ Validation software revealed similar deviations compared with the reference method. A significant correlation between angular and apical deviations was seen (r = 0.53; p < .001). A greater implant diameter was associated with greater deviations (p = .03). CONCLUSION: The Triple Scan Technique as a system-independent validation procedure as well as the NobelGuide™ Validation software are in accordance with the AMIRA® software. The NobelGuide™ system showed similar or less spatial and angular deviations compared with others.
Assuntos
Implantação Dentária Endóssea/métodos , Implantes Dentários , Cirurgia Assistida por Computador , Desenho Assistido por Computador , Planejamento de Prótese Dentária , Técnicas In Vitro , Arcada Edêntula/reabilitação , Mandíbula , Poliuretanos , Software , Resultado do TratamentoRESUMO
BACKGROUND: Intrabony temperature increase is not only dependent on shearing energy and mechanical friction between bone and surgical drill but is also related to heat capacity and thermal conductivity of the surrounding bone and the applied surgical instrument. Thus time of occurrence of the highest temperature rise can be expected after the shearing process of the osteotomy, potentially affecting the process of osseointegration. PURPOSE: The aim of this study was to evaluate temperature changes during the shearing and withdrawing processes during osteotomies. MATERIALS AND METHODS: An overall 160 automated intermittent osteotomies (10/16 mm drilling depth) with 2 mm diameter twist drills and 3.5 mm diameter conical drills and different irrigation methods (without/external/internal/combined) were performed on standardized bone specimens. The drilling cycles were operated by a computer-controlled surgical system, while a linear motion potentiometer and multichannel temperature sensors in various intrabony levels ensured the real-time documentation of temperature changes during the shearing and withdrawing processes. RESULTS: The highest temperature changes were invariably recorded during the process of withdrawal. Significantly lower temperature changes (p < .02) could be recorded at maximum drilling depths during the shearing process regardless of drilling depth, diameter or irrigation method. During coolant supply, 2 mm diameter twist drills showed higher temperatures (10 mm, p < .01/16 mm, p < .03) compared with 3.5 mm diameter conical implant drills. Internal (10 mm, p < .01) or combined irrigation (16 mm, p < .01) was associated with significantly lower temperatures compared with external irrigation by the use of conical implant drills. CONCLUSIONS: Considering that heat generation during osteotomies is a multifactorial scenario, this study could demonstrate that the highest temperature rise during implant osteotomies occurs during the withdrawing process and that the time of occurrence is influenced by predominant factors such as osteotomy depth and mode of irrigation.
Assuntos
Osteotomia/instrumentação , Animais , Densidade Óssea , Bovinos , Desenho de Equipamento , Fricção , Técnicas In Vitro , Temperatura , Irrigação Terapêutica , Condutividade TérmicaRESUMO
OBJECTIVES: The study was designed to evaluate the clinical use of the NobelGuide(™) concept over a follow-up period of 12 months with respect to implant success and survival rates, development of soft tissue condition and recording of potential surgical and prosthetic complications. In addition, radiological assessment of peri-implant bone levels was performed at the 1-year follow-up post-implant placement. MATERIAL AND METHODS: Thirty patients (male/female = 15/15) with partially dentate and edentulous mandibles and maxillae were included. All patients were planned and operated on using the computer-aided, template-guided treatment concept NobelGuide(™). Overall, 163 implants (NobelReplace(®) Tapered Groovy) were placed (mandible/maxilla = 107/56 implants). Recall appointments were performed after 1-2 weeks, 1, 3, 6 and 12 months after implant placement. Clinical parameters of the soft tissue conditions [e.g. bleeding on probing (BoP), pocket probing depth ≥3 mm (PPD), marginal plaque index (mPI)] and the dentist's esthetic and functional evaluation using a visual analogue scale (VAS) were documented. Marginal bone level was evaluated on radiographs made at implant insertion and at the 1-year follow-up. RESULTS: All 30 patients with 161 implants completed the 1-year follow-up resulting in a cumulative survival rate of 98.8% (two implant losses). Clinical parameters improved in a majority of the implants. The mean marginal bone level at implant insertion and at 1-year follow-up was reported with 0.17 mm (SD 1.24; n = 125) and -1.39 mm (SD 1.27; n = 110), respectively. The mean change in bone level from implant insertion to 1 year was -1.44 mm (SD 1.35; n = 98). CONCLUSIONS: The 1-year follow-up showed a cumulative survival rate and success rate of 98.8% and 96.3%, respectively. Immediate or delayed loading of implants using a flapless, guided surgery approach (NobelGuide(™)) appears to be a viable concept demonstrating good clinical and radiographic outcomes at the 1-year time point.
Assuntos
Desenho Assistido por Computador , Carga Imediata em Implante Dentário/métodos , Arcada Parcialmente Edêntula/reabilitação , Arcada Edêntula/reabilitação , Cirurgia Assistida por Computador , Adulto , Idoso , Idoso de 80 Anos ou mais , Planejamento de Prótese Dentária , Falha de Restauração Dentária , Estética , Feminino , Humanos , Carga Imediata em Implante Dentário/instrumentação , Masculino , Pessoa de Meia-Idade , Índice Periodontal , Resultado do TratamentoRESUMO
PURPOSE: The aim of this study is to assess the impact of insertion torque and implant neck design on peri-implant bone levels and gain insights into dynamic crestal tissue alterations by radiological, clinical, and biochemical examinations. MATERIAL AND METHODS: In this prospective trial, a total of 84 implants (four implants in each patient) in the interforaminal region of 21 edentulous mandibles were randomly alternated according to a split-mouth design. Implant placement was performed using different insertion torques (≤20 Ncm vs >50 Ncm). In each group, one machined and one anodized implant neck design (1.5 mm length) was used in the same jaw side. Evaluation of peri-implant tissues involved radiological, clinical examination and immunoassays for interleukin-1ß. RESULTS: No significant influence of insertion torque or implant neck design on peri-implant bone level was found. Protein levels of interleukin-1ß in the peri-implant crevicular fluid revealed no difference between both insertion torque groups and different neck designs. CONCLUSION: Interactive effects of insertion torque and neck surface modification may exist; however, no clinically significant differences in marginal bone resorption after 1 year could be observed in the edentulous anterior mandible.
Assuntos
Implantes Dentários , Desenho de Prótese , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Arcada Edêntula/cirurgia , Masculino , Pessoa de Meia-Idade , Osseointegração , Estudos ProspectivosRESUMO
OBJECTIVE: The first objective of this pilot study was to evaluate the impact of the hydrophilicity on the early phases of osseointegration. The second objective was to compare two hydrophilic implant surfaces with different geometries, surface roughness, and technologies achieving hydrophilicity. MATERIAL AND METHODS: Twelve weeks after extraction, all four quadrants of nine minipigs received three dental implants, alternating between hydrophilic microrough surfaces (INICELL and SLActive) and a conventional hydrophobic microrough surface. After 5, 10, and 15 days of submerged healing, ground sections were prepared and subjected to histologic and histomorphometric analysis. RESULTS: The histologic analysis revealed a similar healing pattern among the hydrophilic and hydrophobic implant surfaces, with extensive bone formation occurring between day 5 and day 10. With BIC values of greater than 50% after 10 days, all examined surfaces indicated favorable osseointegration at this very early point in healing. At day 15, the mean new bone-to-implant contact (newBIC) of one hydrophilic surface (INICELL; 55.8 ± 14.4%) was slightly greater than that of the hydrophobic microrough surface (40.6 ± 20.2%). At day 10 and day 15, an overall of 21% of the implants had to be excluded from analysis due to inflammations primarily caused by surgical complications. CONCLUSION: Substantial bone apposition occurs between day 5 and day 10. The data suggest that the hydrophilic surface can provoke a slight tendency toward increased bone apposition in minipigs after 15 days. A direct comparison of two hydrophilic surfaces with varying geometries is of limited relevance.
Assuntos
Implantes Dentários , Materiais Dentários/química , Osseointegração/fisiologia , Titânio/química , Condicionamento Ácido do Dente/métodos , Animais , Reabsorção Óssea/patologia , Interface Osso-Implante/patologia , Corrosão Dentária/métodos , Feminino , Interações Hidrofóbicas e Hidrofílicas , Mandíbula/patologia , Maxila/patologia , Modelos Animais , Nitrogênio/química , Osteogênese/fisiologia , Projetos Piloto , Hidróxido de Sódio/química , Estomatite/patologia , Propriedades de Superfície , Suínos , Porco Miniatura , Fatores de TempoRESUMO
OBJECTIVES: This prospective study was intended to evaluate the overall deviation in a clinical treatment setting to provide for quantification of the potential impairment of treatment safety and reliability with computer-assisted, template-guided transgingival implantation. MATERIAL AND METHODS: The patient population enrolled (male/female=10/8) presented with partially dentate and edentulous maxillae and mandibles. Overall, 86 implants were placed by two experienced dental surgeons strictly following the NobelGuide™ protocol for template-guided implantation. All patients had a postoperative computed tomography (CT) with identical settings to the preoperative examination. Using the triple scan technique, pre- and postoperative CT data were merged in the Procera planning software, a newly developed procedure - initially presented in 2007 allowing measurement of the deviations at implant shoulder and apex. RESULTS: The deviations measured were an average of 0.43 mm (bucco-lingual), 0.46 mm (mesio-distal) and 0.53 mm (depth) at the level of the implant shoulder and slightly higher at the implant apex with an average of 0.7 mm (bucco-lingual), 0.63 mm (mesio-distal) and 0.52 mm (depth). The maximum deviation of 2.02 mm was encountered in the corono-apical direction. Significantly lower deviations were seen for implants in the anterior region vs. the posterior tooth region (P<0.01, 0.31 vs. 0.5 mm), and deviations were also significantly lower in the mandible than in the maxilla (P=0.04, 0.36 vs. 0.45 mm) in the mesio-distal direction. Moreover, a significant correlation between deviation and mucosal thickness was seen and a learning effect was found over the time period of performance of the surgical procedures. CONCLUSION: Template-guided implantation will ensure reliable transfer of preoperative computer-assisted planning into surgical practice. With regard to the required verification of treatment reliability of an implantation system with flapless access, all maximum deviations measured in this clinical study were within the safety margins recommended by the planning software.
Assuntos
Implantação Dentária Endóssea/métodos , Arcada Parcialmente Edêntula/reabilitação , Arcada Edêntula/reabilitação , Cirurgia Assistida por Computador , Tomografia Computadorizada por Raios X , Adulto , Idoso , Análise de Variância , Desenho Assistido por Computador , Implantação Dentária Endóssea/instrumentação , Implantes Dentários , Planejamento de Prótese Dentária , Prótese Dentária Fixada por Implante , Feminino , Humanos , Arcada Edêntula/diagnóstico por imagem , Arcada Edêntula/cirurgia , Arcada Parcialmente Edêntula/diagnóstico por imagem , Arcada Parcialmente Edêntula/cirurgia , Modelos Lineares , Masculino , Mandíbula , Maxila , Pessoa de Meia-Idade , Estudos Prospectivos , Resultado do TratamentoRESUMO
OBJECTIVE: Graft consolidation follows a gradient that reflects the properties of bone substitutes at sites of sinus augmentation. Here we present an analytical method to investigate the process of graft consolidation taking the distance from the maxillary host bone into account. MATERIAL AND METHODS: We therefore evaluated histological specimens, 6 and 12 weeks after the sinus of minipigs was augmented with Bio-Oss((R)), a deproteinized bovine bone mineral, and Ostim((R)), an aqueous paste of synthetic nanoparticular hydroxyapatite. A curve was drawn that represents the changes in histomorphometric parameters within a given distance from the maxillary host bone. RESULTS: Based on this curve, three regions of interest were defined: R1 (0-1 mm) the bridging distance where new bone is laid onto the host bone, R2 (2-3 mm) a region of osteoconduction where new bone exclusively grows on the biomaterial, R3 (4-5 mm) and a region of osteoconduction where bone formation has reached its maximal extension. Qualitative and quantitative analysis of the three regions can reveal differences in graft consolidation, depending on the bone substitutes and the observation period [Bone volume (BV) per tissue volume after 6 weeks: R1: 19+/-8.4% for Bio-Oss((R)) and 42.9+/-13.2% for Ostim((R)) (P=0.03), R2: 3+/-2.4% for Bio-Oss((R)) and 14.7+/-9.5% for Ostim((R)) (P=0.03), R3: 5+/-4.1% for Bio-Oss((R)) and 5.3+/-5.3% for Ostim((R)) (P=0.86). BV per tissue volume after 12 weeks: R1: 38.0+/-13.3% for Bio-Oss((R)) and 53.3+/-6.6 for Ostim((R)) (P=0.04), R2: 14+/-12.2 for Bio-Oss((R)) and 26.4+/-11 for Ostim((R)) (P=0.18), R3: 6.6+/-7 for Bio-Oss((R)) and 10.7+/-5.8 for Ostim((R)) (P=0.32) after 12 weeks]. CONCLUSION: Based on the graft consolidation gradient, the impact of bone substitutes to modulate the process of bone formation and the kinetic of degradation within a distinct region of the augmented sinus can be investigated.
Assuntos
Aumento do Rebordo Alveolar/métodos , Regeneração Óssea/efeitos dos fármacos , Substitutos Ósseos/farmacologia , Maxila/cirurgia , Osseointegração/efeitos dos fármacos , Animais , Regeneração Óssea/fisiologia , Remodelação Óssea/efeitos dos fármacos , Remodelação Óssea/fisiologia , Bovinos , Hidroxiapatitas/farmacologia , Estudos Longitudinais , Maxila/fisiologia , Seio Maxilar/cirurgia , Minerais/farmacologia , Modelos Biológicos , Nanopartículas , Osseointegração/fisiologia , Osteogênese/efeitos dos fármacos , Osteogênese/fisiologia , Suínos , Porco MiniaturaRESUMO
OBJECTIVES: To determine the effect of magnetron-sputtered calcium phosphate coating of implants on the later stages of osseointegration in a non-human primate model. MATERIAL AND METHODS: Eighteen and 20 implants with a 0.1 microm amorphous calcium phosphate coating and a turned surface, respectively, were inserted in the anterior upper and lower jaw of adult non-human primates. Following a 7.5 months healing period, one part of the implants remained in the submerged position. The other part of implants was connected to healing abutments to allow peri-implant inflammation to occur. After another 20 months, histologic and histomorphometric analysis of the peri-implant area was performed. RESULTS: Submerged implants with a calcium phosphate coating and a turned surface showed no signs of an inflammatory reaction. The histomorphometric parameters 'bone volume per tissue volume' (BV/TV) and 'bone-to-implant contacts' (BIC) were not affected by calcium phosphate coating. Non-submerged implants of both groups showed occasionally signs of inflammation at the implant-abutment junction. Histomorphometric analysis revealed that the distance between the implant-abutment junction and the most coronal level (where bone was attached to the implant) as well as BV/TV and BIC were independent from the surface modification. CONCLUSION: Our results show that dental implants with calcium phosphate coating behave similar to turned implants independently whether they are connected to healing abutments or remain submerged. Ultra-thin calcium phosphate coating can combine the positive effects of calcium phosphate during the early stage of osseointegration without causing impairment of the later stages.
Assuntos
Fosfatos de Cálcio/uso terapêutico , Materiais Revestidos Biocompatíveis/uso terapêutico , Implantes Dentários , Materiais Dentários , Planejamento de Prótese Dentária , Osseointegração/efeitos dos fármacos , Titânio , Animais , Remodelação Óssea/fisiologia , Dente Suporte , Cálculos Dentários/classificação , Materiais Dentários/química , Placa Dentária/classificação , Processamento de Imagem Assistida por Computador , Masculino , Mandíbula/patologia , Mandíbula/cirurgia , Maxila/patologia , Maxila/cirurgia , Papio , Distribuição Aleatória , Propriedades de Superfície , Fatores de Tempo , Titânio/químicaRESUMO
OBJECTIVES: This prospective clinical study was designed to examine the healing process during the first 12 months after sinus grafting (SG) with autogenous culture-expanded bone cells (ABC) and bovine bone mineral (BBM) histomorphometrically and radiologically. MATERIAL AND METHODS: Twenty-two sinuses of 12 patients (mean age 56.2+/-9.3 years) were grafted. Four weeks before, SG bone biopsies were obtained with a trephine burr and the bone cells were isolated and expanded. Every sinus was grafted with BBM and ABC. After 6 months, a biopsy was taken from each sinus and implants (n=82) were placed. These were uncovered after another 6 months and fitted with dentures. The percent newly formed bone (NB) and the NB-to-BBM contact area were determined on undecalcified histologic sections. The sinus graft volume was evaluated by dental CT after SG (CT 1), after implant placement (CT 2) and after implant uncovery (CT 3). RESULTS: Postoperative healing was uneventful. The NB was 17.9+/-4.6% and the contact area 26.8+/-13.1%. The graft volume (in mm(3)) was 2218.4+/-660.9 at the time of CT 1, 1694+/-470.4 at the time of CT 2 and 1347.9+/-376.3 at the time of CT 3 (P<.01). Three implants were lost after uncovery. Reimplantation and prosthodontic rehabilitation were successful throughout. CONCLUSIONS: These results suggest that SG with ABC and BBM in a clinical setting provides a bony implant site which permits implant placement and will tolerate functional loading.
Assuntos
Aumento do Rebordo Alveolar/métodos , Substitutos Ósseos/uso terapêutico , Transplante Ósseo/métodos , Maxila/cirurgia , Seio Maxilar/cirurgia , Minerais/uso terapêutico , Osteócitos/transplante , Engenharia Tecidual/métodos , Adulto , Biópsia , Matriz Óssea/transplante , Técnicas de Cultura de Células , Implantação Dentária Endóssea , Implantes Dentários , Feminino , Seguimentos , Humanos , Processamento de Imagem Assistida por Computador/métodos , Masculino , Pessoa de Meia-Idade , Osseointegração/fisiologia , Osteogênese/fisiologia , Fotografia Dentária , Estudos Prospectivos , Coleta de Tecidos e Órgãos/métodos , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
OBJECTIVES: Thanks to their predictably high-success rates, dental implants have gained a firm place among the treatment options for edentulous and partially dentate patients in state-of-the-art dentistry. As a result, the need for high-level basic and continued training in implant dentistry is increasing. The present questionnaire-based survey was designed to shed light on the current state of implant training, any points of criticism and the need for a standardized training format in Europe. MATERIAL AND METHODS: Between July and November 2006, a 14-item questionnaire was sent to 37 opinion leaders in 29 European countries. The questionnaires sent back were processed electronically and evaluated statistically. RESULTS: 82.8% of the participating opinion leaders responded. In the majority of the participating countries (87.5%), courses are funded by the industry. Most of the courses (43%) are confined to a few days and mainly consist of lectures in theory and hands-on training. Of the attendees, most are general dental practitioners (29%). These perform as many implant treatments as specialized dentists. In 83% of the participating countries, a standardized certified training format in implant dentistry is considered to be required. CONCLUSION: As implant dentistry is increasingly shifting from competence centers to general dental practitioners in the practice setting, standardized training concluded with a certified diploma has become necessary. This would provide for more transparency and for disseminating state-of-the-art knowledge independent of the implant-manufacturing industry.
Assuntos
Implantação Dentária Endóssea , Implantes Dentários , Educação em Odontologia , Certificação , Competência Clínica , Currículo/normas , Educação em Odontologia/legislação & jurisprudência , Educação em Odontologia/normas , Educação Continuada em Odontologia , Europa (Continente) , Odontologia Geral/educação , Odontologia Geral/legislação & jurisprudência , Humanos , Indústrias/economia , Licenciamento em Odontologia , Faculdades de Odontologia , Cirurgia Bucal/legislação & jurisprudência , Inquéritos e Questionários , Apoio ao Desenvolvimento de Recursos HumanosRESUMO
The aim of this study was to evaluate the clinical relevance of horizontal distraction osteogenesis (DO) with bone micro screws for reconstructing knife-edge alveolar crests before implant placement. Horizontal DO was performed in upper and lower alveolar crests of seven patients with resorption class IV according to Cawood and Howell. After osteotomy and a 1-week latency period, micro bone screws were reset daily for horizontal expansions by 0.5 mm. Dental implants were placed in the distracted area following a consolidation period of 12 weeks. Computer tomography was performed before DO and implant placement. Morphometric analysis showed a mean gain of 34.01 mm(2) (95% confidence interval [CI]: 10.55-57.48) in bone area and of 3.06 mm (95% CI: 1.81-4.31) in horizontal width, i.e. the horizontal dimension of the alveolus was approximately doubled within the first 5 mm of height. All 12 implants placed into the distracted area fulfilled the success criteria of stable osseointegration after 1 year of functional loading according to Albrektsson and colleagues. Despite the limited number of patients treated, data from the clinical study of horizontal DO with bone micro screws suggest that the generation of sufficient hard tissue in previously knife-edge alveolar crests for subsequent implant placement was possible.
Assuntos
Perda do Osso Alveolar/cirurgia , Processo Alveolar/cirurgia , Implantação Dentária Endóssea/métodos , Osteogênese por Distração/métodos , Adulto , Perda do Osso Alveolar/diagnóstico por imagem , Processo Alveolar/anatomia & histologia , Processo Alveolar/diagnóstico por imagem , Parafusos Ósseos , Implantes Dentários , Métodos Epidemiológicos , Feminino , Humanos , Masculino , Doenças Maxilares/diagnóstico por imagem , Doenças Maxilares/cirurgia , Osteogênese por Distração/instrumentação , RadiografiaRESUMO
The purpose of this study was to determine the peri-implant soft tissue dimension (PSD) and peri-implant bone level (BL) of dental implants with different designs and surface modifications after functional loading without oral hygiene. Three types of dental implants were placed in the posterior jaws of adult baboons, three of the same design per quadrant, and fitted with fixed partial dentures. After 1.5 years of functional loading and plaque accumulation, all implants showed severe peri-implant mucositis and comparatively high BL. A histomorphometric evaluation of the sulcus depth (SD), the dimension of the junctional epithelium (JE) and the connective tissue contact (CTC) resulted in no significant differences between the three implant designs, neither in the maxilla nor in the mandible (P>0.05). The sum of SD, JE and CTC forming the PSD was nearly the same in the maxilla (commercially pure titanium, CpTi: 3.5 mm 2.9/4.1 confidence interval (CI); titanium plasma sprayed (TPS): 3.5 mm 2.9/4.2 CI; sand blasted acid-etched (GBAE): 3.2 mm 2.7/3.9 CI) and in the mandible (CpTi: 3.2 mm 2.6/3.8 CI; TPS: 3.2 mm 2.6/3.8 CI; GBAE: 3.2 mm 2.7/3.9 CI; P>0.05). There was no difference in BL around the three implant designs (maxilla: CpTi: 0.9 mm 0.5/1.6 CI; TPS: 0.9 mm 0.5/1.5CI; GBAE: 0.9 mm 0.5/1.6 CI; mandible: CpTi: 0.8 mm 0.5/1.2 CI; TPS: 0.6 mm 0.4/0.9 CI; GBAE: 0.7 mm 0.5/1.1 CI; P>0.05). Overall, the data presented did not show any significant differences in peri-implant soft tissue conditions in baboons. Moreover, plaque accumulation and propagation of peri-implant mucositis after 1.5 years of functional loading was not influenced by implant design and surface modifications in baboons.