[The effect of hyperbaric oxygenation on the microcirculation, oxygen budget and acid-base equilibrium in patients with diabetic angiopathy of the lower extremities]. / Vliianie giperbaricheskoi oksigenatsii na mikrotsirkuliatsiiu, kislorodnyi biudzhet i kislotno-shchelochnoe ravnovesie u bol'nykh s diabeticheskoi angiopatiei nizhnikh konechnostei.

These effects were studied in 52 patients with degrees III-IV diabetic angiopathies of the lower limbs. Microcirculation parameters were found changed in this patient population, this leading to disorders of the oxygen budget and development of metabolic acidosis. Development of destructive changes in the limb evidences failure of the compensatory adaptive mechanisms of microcirculation. Addition of hyperbaric oxygenation to multiple-modality treatment of patients with diabetic angiopathies was conducive to improvement of the blood rheology, of tissue saturation with oxygen, and to essential reduction of metabolic acidosis. The detected microcirculation disorders necessitate addition to the therapeutic complex of the drugs improving the biophysical characteristics of the blood.

[Experimental substantiation of the use of regional detoxication therapy in acute ischemia of the limbs]. / Eksperimental'noe obosnovanie primeneniia regionarnoi detoksikatsionnoi terapii pri ostroi ishemii konechnostei.

In the experiment on dogs, the authors modelled acute ischemia of the extremities and studied the activity of lactate dehydrogenase in the blood serum. In circulatory ischemia for 2 and 4 h, the metabolism in muscular tissue normalized by day 30 after restoration of blood flow. Circulatory hypoxia for 7 and 9 h led to failure of the compensatory-adaptive mechanisms of homeostasis of the muscular tissue and required performance of regional detoxication therapy before restoration of circulation in the extremity.