RESUMO
BACKGROUND: Head and neck cancer is the sixth most common cancer worldwide, with oral squamous cell carcinoma (OSCC) being the most representative type. OSCC is a public health problem with high morbidity and poor survival rate. Epithelial-mesenchymal transition is emerging as a hallmark in OSCC. METHODS: In this study, we described the role of microRNAs in epithelial-mesenchymal transition regulation in OSCC based on a PubMed search using articles published in English between January 1, 2010, and January 31, 2018. RESULTS: MicroRNA's regulatory networks seem to be a hallmark of epithelial-mesenchymal transition in OSCC pathophysiology becoming a growing challenge to design new studies and strategies from biology to clinical applications. CONCLUSION: Therefore, we propose that targeting therapies to epithelial-mesenchymal transition-type cells, namely, coordinating microRNAs and/or hydrophobic drugs, such as conventional therapy, could be a promising strategy to improve the outcomes of patients with OSCC.
Assuntos
Transição Epitelial-Mesenquimal , MicroRNAs/genética , Neoplasias Bucais/genética , Carcinogênese/genética , Carcinoma de Células Escamosas/genética , Movimento Celular/genética , Regulação Neoplásica da Expressão Gênica , Humanos , Nanotecnologia , Invasividade Neoplásica/genéticaRESUMO
Freqüentemente recorre-se à produção de sistemas gastrorretentivos para modular a liberação de fármacos a partir de sistemas farmacêuticos com vistas ao aumento do tempo de permanência do fármaco no trato gastrointestinal. Umas das estratégias mais interessantes passa pela produção de sistemas flutuantes. Estes podem ser classificados em dois grupos: sistemas flutuantes efervescentes e sistemas flutuantes não-efervecentes. Neste artigo apresenta-se uma revisão bibliográfica do que tem sido produzido nesta área nos últimos anos.
Gastro-retentive systems are often produced in order to modulate drugs release from pharmaceutical forms and in this way to increase drug residence time in the gastrointestinal tract. One of the most interesting strategies consists in the preparation of floating devices. These can be classified into two groups: effervescent systems and non-effervescent systems. A review of what has been done in the last years is presented in this article.
