RESUMO
Effects were studied of hemosorption on the system of homeostasis in patients with chronic glomerulonephritis presenting with nephrotic syndrome. An optimum graphic express method of control of the homeostasis system state was found, permitting predicting thrombohemorrhagic complications after single-session hemosorption (significance 99.9%). Strategies were identified for correction of changes in coagulogrammes in such patients along with devising measures to prevent the above complications.
Assuntos
Glomerulonefrite/sangue , Hemoperfusão/efeitos adversos , Hemorragia/sangue , Hemostasia , Síndrome Nefrótica/sangue , Trombose/sangue , Adulto , Doença Crônica , Feminino , Glomerulonefrite/complicações , Glomerulonefrite/terapia , Hemoperfusão/métodos , Hemorragia/etiologia , Humanos , Masculino , Síndrome Nefrótica/complicações , Síndrome Nefrótica/terapia , Prognóstico , Trombose/etiologiaRESUMO
Plasmapheresis was carried out by the continuous method in 10 patients with active forms of glomerulonephritis with the nephrotic syndrome and was found to positively affect hemostasis (reduction of hyperfibrinogenemia, thrombinemia, enhancement of fibrinolysis). Antiaggregants completely controlled negative effect of plasmapheresis on the thrombocyte status. The positive effect was paralleled by clinical improvement.
Assuntos
Glomerulonefrite/terapia , Hemostasia , Síndrome Nefrótica/terapia , Plasmaferese , Testes de Coagulação Sanguínea , Doença Crônica , Glomerulonefrite/sangue , Humanos , Síndrome Nefrótica/sangue , Indução de RemissãoRESUMO
Plasmapheresis (P) was used in the complex treatment of 16 patients with chronic glomerulonephritis (CHG) and nephrotic syndrome. Before P. 12 patients were treated ineffectively with prednisolone and curantyl. After 3-5 sessions of P detoxication was observed in all patients, increased diuresis (15 patients). Renal function normalized in 4 of 5 patients, proteinuria reduced by 50-80%. The authors discuss indications of including P into the complex treatment of patients in whom chronic glomerulonephritis with the nephrotic syndrome was present.