RESUMO
Immunobiological properties of human specific transfer factor (TF) to Staphylococcus aureus antigens were studied. It is shown that this TF activated human leucocytes in vitro as well as in vivo. Antigen specificity of TF's immunomodulating effects is also shown. In vitro we used leucocyte migration inhibition test (IML), macrophage inhibition test (MPI) and rosette formation (E-ros). For testing in vivo we used delayed type hypersensitivity (DTH) skin tests.
Assuntos
Antígenos de Bactérias/imunologia , Staphylococcus aureus/imunologia , Fator de Transferência/imunologia , Animais , Doadores de Sangue , Inibição de Migração Celular , Epitopos/efeitos dos fármacos , Epitopos/imunologia , Cobaias , Humanos , Hipersensibilidade Tardia/imunologia , Imunização/métodos , Ativação Linfocitária/efeitos dos fármacos , Ativação Linfocitária/imunologia , Formação de Roseta , Especificidade da Espécie , Proteína Estafilocócica A/imunologia , Fator de Transferência/farmacologiaRESUMO
Today's statement of transfer factor, an immunostimulator derived from leukocytes which enhances antiinfectious immunity, is observed in the review. Basic biological, physical and chemical characteristics of the transfer factor, its possible action mechanisms, and laboratory and clinical methods of use to cure infectious fungal (Candida, Coccidium), invasive (schistosomiasis, leishmaniasis, cryptosporidiosis), viral (varicella zoster, ophthalmic herpes, Herpes simplex types 1 and 2, H. zoster, H. simplex ceratitis, genital herpes, human herpes virus type 6, postherpetic neuritis, hepatitis B, AIDS), and bacterial infections (Mycobacterium leprae, M. tuberculosis, M. fortuitum, Salmonella cholerae suis, S. dublin, S. Virchov, Brucella abortus, Actinobacillus pleuropneumoniae, bacterial sepsis, Staphylococcus) are described.