3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers' Absolute Configuration.

4-Nitro and 7-nitro propranolol have been recently synthesized and characterized by us. (±)-4-NO2-propranolol has been shown to act as a selective antagonist of 6-nitrodopamine (6-ND) receptors in the right atrium of rats. As part of our follow-up to this study, herein, we describe the first synthesis of (±)-3-nitroatenolol as a probe to evaluate the potential nitration of atenolol by endothelium. Chiral chromatography was used to produce pure enantiomers. By using Riguera's method, which is based on the sign distribution of ΔδH, the absolute configuration of the secondary alcohol was determined.

Ground-dwelling Spider Communities Respond to Changes in Riparian Vegetation Widths.

Spiders play a key role in the ecological dynamics in riparian habitats. However, most studies on the effects of changes in riparian habitats on spider communities have focused on the conversion of riparian forest to other land uses rather than on a gradient of forest widths. We assessed the community structure of ground-dwelling spiders in riparian vegetation fragments with varying widths in Southern Brazil. We selected four fragments with different riparian vegetation widths (> 40 m; < 30 m; < 15 m; < 5 m). In each fragment, spiders were seasonally collected using pitfall traps. We tested the effects of riparian vegetation widths and environmental variables (litter height, litter cover and canopy openness) on the taxonomic and guild composition of spider communities. The taxonomic and guild composition of ground-dwelling spiders varied among the widest (> 40 and < 30 m) and narrower riparian widths (< 15 m and < 5 m). While hunting spiders were associated with the narrower widths, web-building spiders were associated with the wider widths. Spider composition was influenced by the leaf litter height in the widest widths (> 40 and < 30 m) and by canopy openness in the narrowest width (< 15 m). Reductions in riparian vegetation were associated with significant changes in the community structure of ground-dwelling spiders, likely through top-down mechanisms associated with the higher litter input in wider fragments. In summary, the fragmentation of the riparian forests of Sothern Brazil are negatively associated with web-building spiders.