1.
J Neurophysiol
; 96(2): 524-5, 2006 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16835361
Assuntos
Inibidores da Captação Adrenérgica/farmacologia , Potenciais Somatossensoriais Evocados/efeitos dos fármacos , Metilfenidato/farmacologia , Norepinefrina/fisiologia , Córtex Somatossensorial/efeitos dos fármacos , Sistema Nervoso Simpático/fisiologia , Transmissão Sináptica/fisiologia , Animais , Eletrofisiologia , Masculino , Norepinefrina/metabolismo , Ratos , Ratos Long-Evans , Sistema Nervoso Simpático/efeitos dos fármacos , Sistema Nervoso Simpático/metabolismo
2.
Science
; 306(5697): 882-4, 2004 Oct 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15514161
RESUMO
The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.