Long-term effect of chemotherapy after ovarian decortication on the ovarian function in women surviving cancer.

PURPOSE: Ovarian decortication may affect ovarian function. We investigated the status of ovarian reserve after ovarian decortication plus chemotherapy at a stage of presumed stabilized recovery in women surviving cancer. METHODS: We searched our database for cancer survivors subjected to ovarian decortication and chemotherapy at least 3 years previously. Ovarian function was explored for levels of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), and estradiol (E2), and menstrual pattern. RESULTS: Forty women (mean age 29.6 (SD, 6.1) years) were assessed at a mean of 4.7 (1.5) years after surgery. The predecortication levels of AMH and FSH changed at post-treatment from 2.2 (1.4) to 0.5 (1.3) ng/mL for AMH (p < 0.001) and from 4.7 (2.1) to 16.7 (21. 6) IU/L for FSH (p < 0.001). Amenorrhea consistent with primary ovarian insufficiency (POI) was diagnosed in 11 women, and normal ovarian reserve (AMH ≥ 1.0 ng/mL) was found in 4 of the 21 women who recovered regular cycles. Logistic regression confirmed AMH as an independent predictor of diminished ovarian reserve (OR = 0.24, 95% CI: 0.04-0.63, p = 0.025) and POI (OR = 0.11, 95% CI: 0.01-0.52, p = 0.027), and age was predictive of POI (OR = 1.36, 95% CI: 1.08-1.96, p = 0.035) and of irregular menstrual cycle (OR = 1.20, 95% CI: 1.03-1.46, p = 0.034). CONCLUSION: Ovarian decortication plus chemotherapy had a deleterious effect when assessed at a stage of stabilized ovarian recovery, but whether ovarian decortication had a specific impact cannot be revealed from our data.

Estudio prospectivo y aleatorizado de los resultados a largo plazo de la hernioplastia inguinal con malla autoadhesiva frente a la técnica convencional con malla de polipropileno y sutura de fijación / Prospective randomized trial of long-term results of inguinal hernia repair using autoadhesive mesh compared to classic Lichtenstein technique with sutures and polypropylene mesh

INTRODUCCIÓN: Las mallas autoadhesivas se plantean como una alternativa para disminuir el dolor crónico y las recidivas en la hernioplastia inguinal. Pretendemos determinar si el empleo de estas mallas representa algún beneficio en el resultado a largo plazo en comparación con la técnica clásica de Lichtenstein fijando la malla con suturas. MATERIAL Y MÉTODOS: Estudio prospectivo y aleatorizado de pacientes intervenidos de hernia inguinal entre marzo de 2009 y marzo del 2010, incluyendo en el grupo autoadhesivo (AA) 45 individuos en los que se realizó la hernioplastia con malla autoadhesiva y en el grupo Lichtenstein clásico (LC) otros 45 utilizando una malla de polipropileno fijada con sutura monofilar. Se evaluaron tiempo de inactividad, posibles complicaciones, recidivas y grado de dolor al año de la intervención. RESULTADOS: La edad media del grupo AA fue de 60 años frente a los 49 del grupo LC. En ambos, la mayor parte eran varones sin diferencias en las comorbilidades asociadas, siendo el tamaño medio del defecto herniario de 3 cm; en torno al 60% de las hernias eran indirectas. Al año de la intervención, 39 pacientes fueron evaluados en el grupo LC y 38 en el AA. La mediana del tiempo de recuperación de la actividad diaria normal fue de 15 días en ambos grupos. En el grupo AA, el 86,8% estaban asintomáticos, ninguno presentó recidiva herniaria ni precisó tomar analgésicos de forma continua, siendo la mediana del grado de dolor de 0. En el grupo LC, el 87,2% permanecían asintomáticos, un paciente (2,6%) presentó una recidiva y un paciente (2,6%) requería la toma continua de analgésicos por dolor intenso, siendo la mediana de dolor de 0. No hubo mortalidad ni otras complicaciones a largo plazo. CONCLUSIÓN: El empleo de mallas autoadhesivas y parcialmente reabsorbibles en la reparación de la hernia inguinal no presenta diferencias significativas en recuperación, dolor ni complicaciones postoperatorias a largo plazo frente a la hernioplastia con malla de polipropileno fijada con sutura monofilar

INTRODUCTION: The use of autoadhesive meshes with hooks that allow fixation without sutures is a therapeutic alternative to decrease recurrence and chronic pain after inguinal hernia repair. The aim of this study was to evaluate if this kind of mesh has any advantage in long term results in comparison with the classic Lichtenstein technique with sutures and polypropylene mesh. MATERIAL AND METHODS: We report a prospective and randomized study of patients who have been operated on for inguinal hernia between march of 2009 to march 2010, divided into 2 groups of 45 patients. In AutoAdhesive (AA) group, we included patients operated on with an autoadhesive mesh and in Classic Lichtenstein (CL) group we included cases with an inguinal hernioplasty with sutured polypropylene mesh. We evaluated time of inactivity, complications, recurrences and grade of pain after one year. RESULTS: The mean age was 60 years in AA group and 49 in LC group. There were more men than women and there were no differences in co-morbilities between groups. The mean size of hernia orifice was 3 cm in both groups and 60% of the hernias were indirect. After one year, 77 patients were evaluated; 39 in LC group and 38 in AA group. 86,8% and 87,2% of them were asymptomatic. The mean time of recovery of daily activities was 15 days in both groups. There were neither recurrences nor severe chronic pain in the AA group. The mean of grade of pain was 0 (range:0-4) in AA group and 0 (range: 0-5) in LC group. In this group, there was one recurrence and one patient was taking analgesics for intense pain. No mortality nor other long term complications were found. CONCLUSION: The use of autoadhesive and parcial reabsorbible meshes in inguinal hernia repair has no effect on recovery of daily activities, postoperative pain and long term complications compared with hernioplasty with polypropylene mesh fixed with monofilament suture

[Prospective randomized trial of long-term results of inguinal hernia repair using autoadhesive mesh compared to classic Lichtenstein technique with sutures and polypropylene mesh]. / Estudio prospectivo y aleatorizado de los resultados a largo plazo de la hernioplastia inguinal con malla autoadhesiva frente a la técnica convencional con malla de polipropileno y sutura de fijación.

INTRODUCTION: The use of autoadhesive meshes with hooks that allow fixation without sutures is a therapeutic alternative to decrease recurrence and chronic pain after inguinal hernia repair. The aim of this study was to evaluate if this kind of mesh has any advantage in long term results in comparison with the classic Lichtenstein technique with sutures and polypropylene mesh. MATERIAL AND METHODS: We report a prospective and randomized study of patients who have been operated on for inguinal hernia between march of 2009 to march 2010, divided into 2 groups of 45 patients. In AutoAdhesive (AA) group, we included patients operated on with an autoadhesive mesh and in Classic Lichtenstein (CL) group we included cases with an inguinal hernioplasty with sutured polypropylene mesh. We evaluated time of inactivity, complications, recurrences and grade of pain after one year. RESULTS: The mean age was 60 years in AA group and 49 in LC group. There were more men than women and there were no differences in co-morbilities between groups. The mean size of hernia orifice was 3cm in both groups and 60% of the hernias were indirect. After one year, 77 patients were evaluated; 39 in LC group and 38 in AA group. 86,8% and 87,2% of them were asymptomatic. The mean time of recovery of daily activities was 15 days in both groups. There were neither recurrences nor severe chronic pain in the AA group. The mean of grade of pain was 0 (range:0-4) in AA group and 0 (range: 0-5) in LC group. In this group, there was one recurrence and one patient was taking analgesics for intense pain. No mortality nor other long term complications were found. CONCLUSION: The use of autoadhesive and parcial reabsorbible meshes in inguinal hernia repair has no effect on recovery of daily activities, postoperative pain and long term complications compared with hernioplasty with polypropylene mesh fixed with monofilament suture.