A Case of Bilateral Choroidal Effusion after XEN Gel Stent Implantation.

PURPOSE: This study aimed to describe a rare case of bilateral choroidal effusion following a XEN45 implantation. CASE REPORT: An 84-year-old man with primary open-angle glaucoma underwent uneventful ab interno XEN45 device implantation in the right eye. The immediate postoperative period was complicated by hypotony and serous choroidal detachment, which were treated and resolved using steroids and cycloplegic drops. Eight months later, the fellow eye underwent the same surgery, which was followed by choroidal detachment that required transscleral surgical drainage. CONCLUSIONS: This case highlights the importance of a careful postoperative follow-up and a timely intervention in the context of XEN45 implantation, and suggests that choroidal effusion in one eye may be a risk factor for choroidal effusion in the other eye when undergoing the same type of surgery.

A New Bistable Switch Model of Alzheimer's Disease Pathogenesis.

We propose a model to explain the pathogenesis of Alzheimer's disease (AD) based on the theory that any disease affecting a healthy organism originates from a bistable feedback loop that shifts the system from a physiological to a pathological condition. We focused on the known double inhibitory loop involving the cellular prion protein (PrPC) and the enzyme BACE1 that produces amyloid-beta (Aß) peptides. BACE1 is inhibited by PrPC, but its inhibitory activity is lost when PrPC binds to Aß oligomers (Aßo). Excessive Aßo formation would switch the loop to a pathogenic condition involving the Aßo-PrPC-mGluR5 complex, Fyn kinase activation, tau, and NMDAR phosphorylation, ultimately leading to neurodegeneration. Based on the emerging role of cyclic nucleotides in Aß production, and thereby in synaptic plasticity and cognitive processes, cAMP and cGMP can be considered as modulatory factors capable of inducing the transition from a physiological steady state to a pathogenic one. This would imply that critical pharmacological targets for AD treatment lie within pathways that lead to an imbalance of cyclic nucleotides in neurons. If this hypothesis is confirmed, it will provide precise indications for the development of preventive or therapeutic treatments for the disease.

Selective inhibition of phosphodiesterase 4D increases tau phosphorylation at Ser214 residue.

Tau is a protein that normally participates in the assembly and stability of microtubules. However, it can form intraneuronal hyperphosphorylated aggregates that are hallmarks of Alzheimer's disease and other neurodegenerative disorders known as tauopathies. Tau can be phosphorylated by multiple kinases at several sites. Among such kinases, the cAMP-dependent protein kinase A (PKA) phosphorylates tau at Ser214 (pTAU-S214), an event that was shown to reduce the pathological assembly of the protein. Given that the neuronal cAMP/PKA-activated cascade is involved in synaptic plasticity and memory, and that cAMP-enhancing strategies demonstrated promising therapeutic potential for the treatment of cognitive deficits, we investigated the impact of cAMP on pTAU-S214 in N2a cells and rat hippocampal slices. Our results confirm that the activation of adenylyl cyclase increases pTAU-S214 in both model systems and, more interestingly, this effect is mimicked by GEBR-7b, a phosphodiesterase 4D inhibitor with proven pro-cognitive efficacy in rodents.

Comunicación y salud en la escuela / School Communicatios and Health

Comunicación y salud en la escuela es, antes que un libro, el resultado de una búsqueda por comprender cómo se instituyen discursos, representaciones y escenarios comunicacionales en la sociedad, los cuales determinan prácticas colectivas coparticipantes en el modelado de la salud de las personas. En este caso, el ámbito escolar y el tratamiento del embarazo adolescente actúan como dimensiones ordenadoras del análisis, y nos llevan a interrogantes que hacen evidente la necesidad de trabajar sobre otros ejes argumentales que den continuidad a las reflexiones en torno a la perspectiva comunicacional de la salud. Lo que comunican los adolescentes, los padres, la escuela, el sistema de salud y los medios masivos de comunicación son algunos de los aspectos tratados en el intento por dilucidar cómo dialogan y articulan entre sí las personas, y cuál es el rendimiento en salud que produce ese encuentro(AU)

Comunicación y salud en la escuela

Contenido: Comunicación y salud. Comunicación y salud en la escuela. Subjetividades y discursos sociales. Embarazo adolescente: dimensión cultural y marco político. Lo que comunican los adolescentes: sentidos y significados. Lo que se comunica en las aulas. Los padres: entre el desconocimiento y la duda. Lo que comunican los medios. Programa Nacional de Salud Sexual y Procreación Responsable. Ley 25673. Acciones contra alumnas embarazadas. Ley Nacional 25584. Programa Nacional de Educación sexual Integral. Ley Nacional 26150. Programa Nacional de Salud Integral en la Adolescencia. Resolución Ministerial 619/2007. Programa Provincial de Salud Reproductiva y Procreación Responsable. Ley provincial 13066