RESUMO
Señor editor: Los pacientes infectados con el nuevo coronavirus, designado como síndrome respiratorio agudo severo coronavirus 2 (SARS-CoV-2), desarrollan la enfermedad Covid-19, que puede causar neumonía grave y generar un compromiso de múltiples órganos. La tormenta de citocinas inflamatorias constituye la liberación excesiva e incontrolada de citocinas proinflamatorias, dentro de las cuales se cuentan las liberadas por los macrófagos (IL-6, IL-10 y TNF-α) que aumentan durante la enfermedad de Covid-19, y son responsables de la injuria a órganos.
Mr. Editor: Patients infected with the new coronavirus, designated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), develop Covid-19 disease, which can cause severe pneumonia and generate multiple organ involvement. The inflammatory cytokine storm is the excessive and uncontrolled release of proinflammatory cytokines, including those released by macrophages (IL-6, IL-10 and TNF-α), which increase during Covid-19 disease and are responsible for organ injury.
RESUMO
No dyspepsia-specific questionnaire currently exists in Spanish. The Spanish Language Dyspepsia Questionnaire (SLDQ) was developed based on Rome dyspepsia criteria, other questionnaires, and common symptoms. Self-reported normal and dyspeptic volunteers (N = 63) in Chiapas, Mexico, participated in a validation study. We assessed intra- and interrater reliability by test-retest studies and established validity by both correlation to the Short Form-36 (SF-36) and comparison of scores between normals and dyspeptics. The total SLDQ score showed a wide distribution (range 0-78, mean 23.7 +/- 21.9). Internal reliability of the SLDQ was high (Cronbach's a = 0.93). Intra- and interrater reliability were excellent (scores from the first and second interviews not statistically different; P = 0.94; intraclass correlation coefficient = 0.96). SLDQ scales correlated appropriately with the SF-36. The SLDQ distinguished self-classified normals from dyspeptics (P < 0.001). The SLDQ fills the unmet need for a valid, reproducible, and multidimensional Spanish-language instrument to measure dyspepsia. Additionally, we have made suggestions for the development of symptom-quantifying questionnaires.
