1.
Bull Exp Biol Med
; 143(3): 323-7, 2007 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18225753
RESUMO
It was shown that the expression of HIF-1alpha in retinal pigment epithelium increased under hypoxic conditions. Eight hours after the start of hypoxic exposure, the expression of HIF-1alpha reached the peak and sustained after 24-hour hypoxia. However, the morphology of PRE cells began to change and the expression of HIF-1alpha decreased after long-term (48-hour) hypoxia. Hypoxia-induced increase in the level of HIF-1alpha in RPE. It can be an important step in choriodal neovascularization.