[Comparative pathomorphological study of the experimental action of carminomycin and rubomycin on the heart]. / Sravnital'noe patomorfologicheskoe issledovanie deistviia na miokard karminomitsina i rubomitsina v éksperimente.

Comparative histological investigation of the toxic effect of carminomycin and rubomycin on the myocardium was carried out on mice BDF. It was found that the level of the morphological changes in the heart muscle depended on the antibiotic dose. The cardiotoxic effect of carminomycin was less pronounced than that of rubomycin.

[Comparative experimental study of the antileukemia activity of carminomycin and rubomycin]. / Sravnitel'noe izuchenie v éksperimente protivoleikoznoi aktivnosti karminomitsina i rubomitsina.

The antileukemic activity of karminomycin and rubomycin was studied comparatively in parallel experiments with respect to 4 strains of transplantable leukemia, i.e. acute non-differentiated leukemia La, acute lymphoblast leukemia, L-1210 and P-388 and subacute lymphoblast leukemia No. 8 CRIHBT. The doses used were adequate by their toxicity. The tests of the therapeutic effectiveness were: an increase in the life time of the animals treated as compared to the control ones, a decrease in the leukocyte count and the number of the blast cells in the peripheral blood, a decrease in the leukemic infiltration of the organs and tissues of the animals treated. It was shown that karminomycin was more effective in the studied leukemia strains when it was used in the doses with equivalent toxicity. The more pronounced antileukemic activity of karminomycin was especially evident from histological examinations, which showed lower infiltration of the organs and tissues of the mice treated with karminomycin by the leukemic cells as compared to the animals treated with rubomycin.