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1.
Allergol Int ; 73(3): 375-381, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38692992

RESUMO

Mucus provides a protective barrier that is crucial for host defense in the lungs. However, excessive or abnormal mucus can have pathophysiological consequences in many pulmonary diseases, including asthma. Patients with asthma are treated with agents that relax airway smooth muscle and reduce airway inflammation, but responses are often inadequate. In part, this is due to the inability of existing therapeutic agents to directly target mucus. Accordingly, there is a critical need to better understand how mucus hypersecretion and airway plugging are affected by the epithelial cells that synthesize, secrete, and transport mucus components. This review highlights recent advances in the biology of mucin glycoproteins with a specific focus on MUC5AC and MUC5B, the chief macromolecular components of airway mucus. An improved mechanistic understanding of key steps in mucin production and secretion will help reveal novel potential therapeutic strategies.


Assuntos
Asma , Muco , Humanos , Asma/metabolismo , Asma/tratamento farmacológico , Muco/metabolismo , Animais , Terapia de Alvo Molecular , Mucinas/metabolismo , Mucina-5AC/metabolismo , Mucina-5B/metabolismo , Mucosa Respiratória/metabolismo , Mucosa Respiratória/imunologia
4.
Int Forum Allergy Rhinol ; 14(5): 986-989, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38146638

RESUMO

KEY POINTS: Individual sinus opacification (ISO) is measurable via a convolutional neural network approach. ISO decreased through 2 years after highly effective modulator therapy was initiated. In adults with cystic fibrosis, ISO did not correlate with quality of life or olfaction.


Assuntos
Fibrose Cística , Rinossinusite , Olfato , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doença Crônica , Fibrose Cística/tratamento farmacológico , Transtornos do Olfato/etiologia , Seios Paranasais , Qualidade de Vida , Olfato/fisiologia
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