[The condition of the system "peroxide oxidation of lipids-antioxidant defense" in mixed saliva of patients with chronic generalized periodontitis].

The comparative analysis was made concerning conditions of the system "Peroxide oxidation of lipids-antioxidant defenses in mixed saliva of patients with chronic disseminated periodontitis of light (n = 45), mean (n = 36) and severe (n = 18) degrees. The control group consisted of 25 clinically healthy persons with intact periodontium. The study revealed that in comparison with control group, in patients with chronic disseminated periodontitis occurred an increasing of content of heptane-soluble diene conjugates, isopropanol-soluble ketodienes and conjugated trienes, ceruloplasmin and a decreasing of level of alpha-tocopherol, especially under severe degree of disease. The study also established a non-linear U-dependence between indicators of the system "Peroxide oxidation of lipids-antioxidant defenses" in mixed saliva and severity of affection of tissues of periodontium in patients with chronic disseminated dermatosis.

[The antidepressant effects of α-lipoic acid and reamberin in murine alloxan diabetes].

The development of alloxan diabetes in mice is followed by a longer duration of despair behavior, homologous depression in man and a concomitant decrease in the activity of animals in the open field. The 2-week course of α-lipoic acid (α-LA) and reamberin in the doses equivalent to the human therapeutic range exerts an antidepressant activity, as appeared by a reduction in despair behavior and activation of sick mice in the open field. The antidepressant effect of 2-week use of α-LA and reamberin is associated with diminished hyperglycemia. Unlike α-LA, reamberin lowers the blood content of glucose in mice with alloxan diabetes, reduces their mortality, and corrects behavioral disorders in the open field even when relatively low doses are singly administered.