Soil and river contamination patterns of chlordecone in a tropical volcanic catchment in the French West Indies (Guadeloupe).

The aim of this study was to identify primary flow paths involved in the chlordecone (CLD) river contamination and quantify the CLD fluxes to assess CLD pollution levels and duration according to a typical catchment of the banana cropping area in the French Indies (Guadeloupe): the Pérou Catchment (12 km(2)) characterized by heavy rainfall (5686 mm year(-1)). Three sub-catchments (SC1, SC2 and SC3) were studied during the hydrological year 2009-2010: a pedological survey combined with a spatialized hydrochemical approach was conducted. The average soil concentration is higher in the Pérou Catchment (3400 µg kg(-1)) than in the entire banana cropping area in Guadeloupe (2100 µg kg(-1)). The results showed that CLD stocks in soils vary largely among soil types and farming systems: the weakest stocks are located upstream in SC1 (5 kg ha(-1)), where a majority of the area is non-cultivated; medium stocks are located in Nitisols downstream in SC3 (9 kg ha(-1)); and the greatest stocks are observed in SC2 on Andosols (12 kg ha(-1)) characterized by large farms. The annual water balance and the hydro-chemical analysis revealed that the three sub-catchments exhibited different behaviors. Pérou River contamination was high during low flows, which highlighted that contamination primarily originated from groundwater contributions. The results showed that only a small part of the catchment (SC2), contributing little to the water flow, comprises a major CLD contribution, which is in agreement with the highly contaminated andosol soils observed there. Another significant result considers that at least 50 years would be required to export the totality of the actual CLD soil stocks retained in the topsoil layer. The actual time for soil remediation will however be much longer considering (i) the necessary time for the chlordecone to percolate and be stored in the shallow aquifers and (ii) its travel time to reach the river.

Seepage patterns of Diuron in a ditch bed during a sequence of flood events.

Although ditches limit surface water contamination, groundwater recharge through ditches in Mediterranean catchments may result in groundwater contamination. We analysed the dynamics of pesticide percolation in ditches by conducting an original lab experiment that mimicked the successive percolation processes that occur during a flood season. Nine successive percolation events were operated on an undisturbed soil column collected from a ditch bed. The infiltrating water was doped with (14)C-Diuron at concentrations that were chosen to decrease between the events so as to correspond to values observed during actual flood events. The water and solute fluxes were monitored during each event, and the final extractable and non-extractable Diuron residues in the column were determined. Two main observations were made. First, a high leaching potential was observed through the ditch bed over a succession of infiltrating flood events, with 58.9% of the infiltrated Diuron and its metabolites leaching. Second, compared with the contamination of surface water circulating in the ditches, the contamination of seepage water exhibited smaller peak values and persisted much longer because of the desorption of Diuron residues stored in the ditch bed. Thus, ditches serve as buffering zones between surface and groundwater. However, compared with field plots, ditches appear to be a preferential location for the percolation of pesticides into groundwater at the catchment scale.

Effect of spatial heterogeneities of water fluxes and application pattern on cadusafos fate on banana-cultivated andosols.

In tropical humid environments under intensive banana production, pesticide transfer in waters can be of particular concern due to heavy rainfall, steep slopes, and soils with high infiltration capacities. The transfer in percolation and runoff waters of the nematicide cadusafos was investigated during a three month field experiment. The spatial heterogeneity of the banana plantation was taken into account by measuring percolation fluxes both under the banana plants and in the interrows with a specially designed lysimeter device installed at 60 cm depth. At the field scale, 0.34% of the pesticide applied was transferred in percolation, 0.13% in runoff. Forty-nine percent of cadusafos losses occurred by percolation under the banana plants, 23% by interrow percolation, and 28% by runoff. Losses were highest during the three weeks following cadusafos application, and this is also when dissipation in the soil was highest (calculated half-life in the soil: 7d). After this period, losses of cadusafos were low, both in soil and waters. Under the banana plant, saturated fluxes carried most of the pesticide, despite total percolation fluxes being at least five-times higher than saturated ones. Although overall pesticide transfer in water was low (0.5% of applied), it was not negligible due to the frequency of pesticide application in these areas.

Paracetamol versus paracetamol-codeine in the treatment of post-operative dental pain: a randomized, double-blind, prospective trial.

BACKGROUND: Codeine is frequently added to paracetamol to treat post-operative dento-alveolar pain; studies have shown effectiveness in relief of post-operative pain at high doses but at the expense of central nervous and gastrointestinal side effects. There has been no trial to compare the efficacy and safety of paracetamol 1000 mg with paracetamol 1000 mg combined with codeine 30 mg. METHOD: A randomized, single centre, double-blind prospective parallel group trial was performed to compare paracetamol 1000 mg with paracetamol 1000 mg with codeine 30 mg for the relief of pain following surgical removal of impacted third molars, and analysed on an intention-to-treat (ITT) basis. Eighty-two patients were assigned randomly to receive either drug for a maximum of three doses. Patients recorded their pain intensity one hour after surgery and hourly thereafter for 12 hours. RESULTS: The average increase in pain intensity over 12 hours was significantly less in patients receiving paracetamol plus codeine than in those receiving paracetamol alone (p=0.03) -1.81 cm/h compared with 0.45 cm/h - a difference of 1.13 cm/h (95 per cent CI: 0.18 to 2.08). Of the patients who received the paracetamol codeine combination, 62 per cent used escape medication compared with 75 per cent of those on paracetamol alone (p=0.20). There was no significant difference between the two groups in the proportion of patients experiencing adverse events (p=0.5). CONCLUSION: A combination of 1000 mg paracetamol and 30 mg codeine was significantly more effective in controlling pain for 12 hours following third molar removal, with no significant difference of side effects during the 12 hour period studied.

Speciation and origin of particulate copper in runoff water from a Mediterranean vineyard catchment.

Fungicide treatments have led to large copper contents of the topsoils of most vineyards. This paper examines the contamination of surface waters by copper in a Mediterranean wine-growing catchment. Its aims were to characterise the forms of copper associated with suspended matter during a heavy autumn storm event and to identify which soils contribute the most to the copper exports. A mixing model involving three reservoirs, corresponding to three soil-landscape units (plateau, terraces and footslope-depression system) and two tracers (reducible iron content and dolomite/calcite ratio) was used to estimate the contribution of each reservoir to erosion during a storm flow. The average copper concentration of the suspended matter was 245 mg kg(-1), of which 1% was exchangeable, 4% acid-soluble, 10% oxidizable, 23% reducible and 63% residual. The soils of the plateau of the catchment (chromic luvisols and haplic calcisols-FAO soil classification) were the source of 42% of copper exports but represented only 27% of the total catchment area.

Herbicide transport to surface waters at field and watershed scales in a Mediterranean vineyard area.

The contamination of soil and runoff water by two herbicides, diuron [N'-(3,4-dichlorphenyl)-N,N-dimethylurea] and simazine (6-chloro-N,N'-diethyl-1,3,5-triazine-2,4-diamine), were monitored on two fields, one no-till and one tilled. Experiments were carried out in a 91.4-ha watershed in southern France during the 1997 growing season in order to understand the patterns of pesticide transport from field to watershed. The persistence of the herbicides in soil was prolonged due to the climatic conditions. At the field scale, annual herbicide loads were due to overland flow and amounted to 65.6 and 6.3 g ha(-1) of diuron for the no-till and tilled field, respectively, and to 29.6 and 1.83 g ha(-1) of simazine. Maximum herbicide concentrations exceeded 580 microg L(-1) during the first storm event after application and decreased thereafter but remained for 8 mo above 0.1 microg L(-1). At the watershed outlet, estimated annual loads amounted to 4.12 g ha(-1) of diuron and 0.56 g ha(-1) of simazine. Among them, 96% of the losses in diuron and 83% of those in simazine were caused by the fast transmission through the network of ditches of the overland flow exiting the fields. For diuron, which was sprayed over most of the vineyards, its in-stream concentrations during storm flow were close to those at the outlet of the fields. The herbicide loads in baseflow were smaller than 0.2 g ha(-1). The patterns of the loads at the field and watershed scales suggested that a major part of the herbicides leaving the fields reinfiltrated to the ground water by seepage through the ditches, and was there degraded or adsorbed.

Spatial variability of soil moisture regimes at different scales: implications in the context of precision agriculture.

Precision agriculture is based on the concept of soil-specific management, which aims to adapt management within a field according to specific site conditions in order to maximize production and minimize environmental damage. This paper examines how the nature and sources of variation in soil moisture regimes affect our ability to simulate soil water behaviour within a field with adequate precision in order to advise optimal soil-specific management. Field examples of variation in soil moisture regimes are described to illustrate the difficulties involved. A discussion identifies three main points. First, it is recognized that the current modelling approaches to soil moisture regimes do not sufficiently account for local heterogeneities in soil and crop characteristics such as soil morphology and rooting patterns. Second, the estimation of within-field variation of soil hydraulic properties is difficult because of large short-range variation of the properties and general lack of observed data; one way to overcome this problem is to seek new measurement techniques or to find easy-to-measure auxiliary variables spatially correlated to the variables of interest. Last, as pollution impacts often become noticeable to society at scales larger than the scale of agricultural management, hydrological modelling can serve for linking both scales and advising agricultural practices that minimize undesirable pollution effects.

Phenotypic and functional analysis of peripheral blood lymphocytes in oral lichen planus.

To assess cellular immunity in oral lichen planus (OLP), peripheral blood mononuclear cells (PBMC) were obtained from 19 OLP patients and 30 control subjects. The proportions of circulating CD45RA+ and CD29+ lymphocyte subsets were determined. The proliferative activity of PBMC to the non-specific plant mitogens phytohemagglutinin (PHA) and concanavalin A (Con A) was examined together with the spontaneous proliferative response and the response in the autologous mixed lymphocyte reaction (AMLR). In the OLP group, the proportion of CD4+ CD45RA+ T lymphocytes was significantly less than control subjects and the proportion of CD4+ CD29+ T lymphocytes was increased significantly. The proliferative response to PHA was similar in OLP and controls subjects. Con A-stimulated PBMC proliferation was decreased significantly in the OLP group. Spontaneous PBMC proliferation in patients with non-reticular lesions was significantly less than control subjects. Despite a mildly depressed response in the AMLR in OLP patients, this result was not statistically significant. Results of the phenotypic analysis of peripheral blood lymphocytes indicate a decreased proportion of naive T cells and an increased proportion of primed memory T cells, although the antigen specificity of these memory cells remains to be determined. Results of the functional assays would seem to reflect this phenotypic shift, and as T cells responding to Con A stimulation and in the AMLR possess suppressor-inducer activity, these results may also suggest an association between OLP and defective innate T cell-mediated suppressor circuits.