[Tthe efficacy and safety of drug therapy divaza in patients with chronic cerebral ischemia]. / Effektivnost' i bezopasnost' primeneniya preparata divaza v terapii patsientov s khronicheskoi ishemiei golovnogo mozga.

AIM: To evaluate the efficacy and safety of divazа in the treatment of cognitive and emotional disorders in patients with chronic cerebral ischemia (CCI) based on clinical findings and laboratory markers of endothelial dysfunction. MATERIAL AND METHODS: Thirty patients with CCI, aged 40 to 70 years, were examined. All patients were treated with divazа (2 tablets 3 times a day) for 12 weeks. Cognitive functions and markers of endothelial dysfunction (the activity of endothelial NO-synthase (eNOS), the number of circulating desquamated endothelial cells in blood plasma) were measured at baseline and after treatment. RESULTS: Divazа significantly reduced the severity of clinical symptoms and had a positive effect on endothelial dysfunction normalizing the tone of cerebral vessels and preventing deendotheliazation. CONCLUSION: The use of divazа resulted in clinical improvement and normalization of markers of endothelial dysfunction as well.

Use of impaza in the treatment of erectile dysfunction in patients with essential hypertension and CHD.

Impaza treatment of erectile dysfunction in patients with essential hypertension and CHD receiving cardiotropic therapy improved erectile function and increased reserve circulation. Addition of impaza to the treatment protocol in cardiological patients considerably increased perfusion and reduced the content of desquamated epitheliocytes. No side effects of impaza were noted.

[Professional stress and development of stress-induced hypertension].

AIM OF THE STUDY: to elucidate rates of development of arterial hypertension (AH) at working place (wp), risk factors of cardiovascular diseases (CVD), anxiety depressive disorders in persons with professional stress. We carried out monitoring of arterial pressure during working hours and hours of rest, assessed risk factors of CVD development, and evaluated severity of symptoms of anxiety and depression using the Hamilton scale in 138 men (mean age 40.0+/-1.2 years). Results of the study evidenced for high frequency (46.4%) of development of AHwp among representatives of stressful occupations. Patients with AHwp have risk factors of CVD development and total coronary risk comparable with those of patients with hypertensive disease. Patients with AH have more pronounced anxiety depressive disorders than healthy subjects.

[Treatment of erectile dysfunction in patients with essential hypertension and ischemic heart disease].

AIM: To evaluate the effect of impasa on activity of N0-dependent processes in cardiological patients with erectile dysfunction (ED). MATERIAL AND METHODS: 58 patients with IHD and angina of effort and 48 patients with hypertension participated in the study of efficacy of conventional treatment combined with impasa on the course of the basic disease, peripheral blood count of desquamated endotheliocytes, microcirculation and erectile function. RESULTS: IHD patients given impasa showed increased exercise tolerance, less number of anginal attacks, improved coronary microcirculation, improved metabolism of vascular endothelium. Manifestations of erectile dysfunction regressed. Hypotensive therapy also reduced the above manifestations in hypertensive patients. CONCLUSION: The addition of impasa to conventional cardiotropic and hypotensive therapy promotes ED regression.

[Treatment of erectile dysfunction in patients with ischemic heart disease and angina of effort].

A total of 58 patients with ischemic heart disease and angina of effort (FC II) (mean age 55.6 years) participating in the study were diagnosed to have erective dysfunction (ED) of a mild (35%), moderate (57%) and severe degree (8%). All the patients were randomized into two groups. Group 1 (n=21, mean age 56.4 years) received standard cardiotropic therapy (nitrates, beta-blockers, ACE inhibitors on demand, diuretics, antioxidants) and placebo. Group 2 (n=37, mean age 54.3 years) received the same standard cardiotropic therapy plus impase (1 tablet each other day for 3 months). The results of the trial show that impase addition to cardiotropic therapy raised exercise tolerance, diminished the number of anginal attacks in mild and moderate exercise, enhanced coronary microcirculatory blood flow, increased reserve circulation index by 34%, improved metabolism of vascular endothelium in the whole body. Impase acts pathogenetically in endothelial insufficiency. Prevention of endothelial dysfunction by impase allows both to stop progression of cardiovascular disease and to prevent erectile dysfunction.

[Computer program for diagnosis, monitoring, and prophylaxis of cardiovascular diseases]. / Komp'iuternaia programma diagnostiki, monitoringa i profilaktiki serdechno-sosudistykh zabolevanii.

Cardiovascular diseases remain the main cause of death among adult population; their incidence can be reduced only using an effective system of primary and secondary prevention. The aim of our study was to develop software for automated recognition of cardiovascular risk factors, prognosis, and evaluation of dyslipoproteinemia phenotypes in lipid centers. Prognostic indexes, lipidogram values are estimated, and the program detects the risk factors (overweight, poor physical training, irrational nutrition, tobacco smoking, etc.) and predicts the summary risk of coronary disease. Neuronal network was used for evaluating the types of dyslipoproteinemias and for cardiovascular prognosis. The input vectors were lipid and lipoprotein concentrations. Output neurons were diagnostic signs of dislipoproteinemia phenotypes or cardiovascular prognosis.

[Effects of nutrition characteristics on blood lipids in patients with dyslipoproteinemia]. / Vliianie osobennostei pitaniia na lipidy krovi u bol'nykh s dislipoproteidemiei.

Prevalence of risk of ischemic heart disease, such as nutrition and dyslipoproteinaemias are discussed. The interrelation of these risk factors with blood lipids was examined. It was found that risk factors are widespread, and population has low knowledge about their significance. Food, contained surplus of cholesterol, saturated fats, carbohydrates and deficiency of polyunsaturated fat acids increased atherogenic blood lipids and decreased antiaterogenic lipoproteins.

[Relationship of different risk factors of ischemic heart disease]. / Vzaimosviz' razlichnykh faktorov riska razvitiia ishemicheskoi bolezni serdtsa.

The spread of ischemic heart disease (IHD) risk factors, such as obesity, smoking, inactivity is discussed. Their relationship with the values of the serum lipid spectrum was examined. A wide spread of IHD risk factors and a low awareness of their implication were found in the population. The former can be reduced by questionnaire survey, interpretation of the presence of individual risk factors, and evaluation of the total risk of IHD. Sanitary and educational work on the pathogenesis of IHD is required for its successful prevention.

[Erythrocyte damage in toxicogenic disseminated intravascular coagulation syndrome induced by viper poison]. / Povrezhdenie éritrotsitov pri toksogennom DVS-sindrome, vyzvannom iadom shchitomordnika.

Total number of red blood cells, their acid resistance, deformability and fragmentation were studied in rats after intramuscular injection of a semilethal dose of viper poison. It was shown that most significant changes in the above parameters took place 120 min after the poison administration: diminution of red blood cell number, disappearance of high-resistant red blood cells, increase of fragmentary cell number, lowering of deformability.

[Experimental and clinical basis for the use of 111In-DTPA for radionuclide cisternography]. / Eksperimental'no-klinicheskoe obosnovanie ispol'zovaniia 111In-DTPA dlia radionuklidnoi tsisternografii.

Modern radiopharmaceuticals are used to get information on the anatomy and function of the liquor system, i. e. they make it possible to monitor a radionuclide biological behavior in vivo by external detection. Complex compounds like diethylene triamine pentacetic acid (DTPA) labeled with 111In or 99mTc are the most common radionuclides used abroad to study the liquor system pathology. The clinicoexperimental studies on the use of the 111In-Ca-DTPA complex for radionuclide cisternography elaborated in this country, took 2 years. Experiments on animals showed that 70% of the administered amount of the radionuclide left the liquor pathways 4 h later. The administration of a clinical dose 5 times as high demonstrated the drug safety. The Soviet radiopharmaceutical was evaluated by comparing under clinical conditions 3 radionuclides: 111In-DTPA (France), 99mTc-DTPA (FRG) and 111In-Ca-DTPA (USSR). The radiological picture of radionuclide distribution by the liquor pathways did not depend on the drug. Radiological signs showed a direct correlation with a disease entity.

[Effect of vitamin E on biochemical processes in erythrocytes]. / Deistvie vitamina E na biokhimicheskie protsessy v éritrotsitakh.

Effect of therapeutic doses of alpha-tocopherol (50 mg) exceeding 10-12-fold the daily consumption of the vitamin, on glycolysis was studied in erythrocytes of rats maintained on a usual diet. After loading of the animals with tocopherol utilization of glucose was increased 2.4-fold, with simultaneous activation of aldolase and phosphohexoisomerase by 34% and 48%, respectively; content of lactate was increased by 40%.