RESUMO
The investigation of single injection of taurine on Lebetina viper' venom-induced shifts of morpho-functional indices of rats' peripheral blood was carried out. It was revealed that taurine eliminates negative effects of influence of venom. The results of investigation allow us to assume that taurine trigger adaptive and compensatory mechanisms of organism in conditions of toxins influence.
Assuntos
Antídotos/farmacologia , Taurina/farmacologia , Venenos de Víboras/toxicidade , Animais , Masculino , Ratos , Ratos WistarRESUMO
The most sensitive organ to any kind of venoms is the skin, whereas muscles response of milder, and the intestine response reveals no difference between effects of different venoms. The isobarin desympathetising effect combined with V.lebetina venom shows that the venom affects thermoregulation interacting with the sympathetic nervous system, and exerts a sympathomimetic effect. This action seems to be not adrenergic as there is no compensation of the catecholamine decrease due to isobarin administration.
Assuntos
Venenos de Abelha/farmacologia , Regulação da Temperatura Corporal/efeitos dos fármacos , Venenos de Serpentes/farmacologia , Animais , Colo/fisiologia , Homeostase , Músculo Esquelético/fisiologia , Especificidade de Órgãos , Ratos , Temperatura Cutânea/efeitos dos fármacos , Especificidade da Espécie , Sistema Nervoso Simpático/fisiologia , Vasoconstrição/efeitos dos fármacos , Vasodilatação/efeitos dos fármacosRESUMO
Temporary compression of spinal cord was modelled in anesthetized cats. The degree of spinal disfunction was estimated by component analysis of far-field somatosensory EPs which were recorded along vertebral column and scalp. Even a weak and short-term compression of spinal cord's dorsal columns changed biopotentials' latencies, amplitudes and interpeak intervals. Usefulness of correlative analysis of interpeak intervals as an additional way of differential evaluation of spinal pathways conductivity, was shown.
Assuntos
Potenciais Somatossensoriais Evocados/fisiologia , Compressão da Medula Espinal/fisiopatologia , Animais , Gatos , Estimulação Elétrica , Eletrodos , Análise de Fourier , Microcomputadores , Medula Espinal/fisiopatologia , Fatores de TempoRESUMO
In acute experiments on anesthetized mature chickens, the bioelectrical activity of epibasal neurons was influenced upon both by means of intradermal histamine injections and direct histamine application to the medial region of n. epibasalis centralis, as well as by uni- and bilateral lesion of this structure. The processes under study were evaluated with respect to the parameters of focal potentials and neuronal reactions induced in n. epibasalis centralis as well as by the measurement of the feather adhesive force, the latter being a correlate for the skin analyzer sensibility. It is shown that the feather adhesive force increases with growing activity of the central neurons and decreases in case of their activity suppression or lesion of the nucleus.