[Congenital uterine anomalies in pregnancy]. / Urodene anomalije materice i trudnoca.

From 1984 to 1989, 805 infertile women were examined hysterosalpingographically and 127 (15.8%) proved to have one of the congenital uterine anomalies. The control group consisted of 45 fertile women with the anatomically normal form of the uterine cavity as was checked by the HSG method. Out of 127 patients, 4 (3.1%) had uterus unicornis, 76 (59.8%) arcuatus, 27 (21.35%) bicornis, 19 (15.0%) septus and 1 (0.8%) didelphys. In the group of 4 cases of the unicornuate uteri, only 1 had spontaneous abortion. In the group of 76 patients with the arcuate uteri, 11 (14.5%) had one or more spontaneous abortions and 4 (5.3%) premature delivery. Out of 48 pregnancies in this group, 14 (29.2%) ended with spontaneous abortion, and out of 24 deliveries, 4 (17.4%) were premature. There was a statistically considerably higher number of spontaneous abortions than in the control group (x2 = 49.8, p = 0.05). In the group of 27 patients with the bicornuate uteri, 12 (44.4%) had spontaneous abortion and 1 (3.7%) a premature delivery. Out of 25 pregnancies, 12 (48.0%) ended with spontaneous abortion, and out of 8 deliveries, 1 ended prematurely. Evident by, there was a considerably higher number of spontaneous abortions than in the control group (x2 = 24.2 p = 0.05). In the group with the septate uteri, out of 19 patients, 12 had spontaneous abortions and 4 premature delivery. Out of 34 pregnancies, 25 (73.5%) ended with spontaneous abortion, and out of 5 deliveries, 4 ended prematurely.(ABSTRACT TRUNCATED AT 250 WORDS)

The effectiveness of intravenously administered immune lymphoid cells against intraperitoneally growing tumor correlates with their homing in the recipients' lymphoid organs.

Intraperitoneally growing Ehrlich ascites tumor (EAT) was eradicated by both i.p. and i.v. injection of serum, and by i.p. injection of spleen cells from mice immune to EAT. However, the i.v. injected immune spleen cells were completely ineffective unless the recipients had been pretreated with cyclophosphamide. The analysis of immune response in mice cured by the combination of cyclophosphamide and cell transfer revealed that they developed a humoral-type immunity to EAT and that the transferred spleen cells did not penetrate into their abdominal cavity. The effect of cyclophosphamide correlated with the extent of seeding of the donor-type cells in the recipients' lymphoid organs. Inasmuch as homing in cyclophosphamide-pretreated mice surpassed that in normal mice three to four times, it appeared that the beneficial effect of cyclophosphamide was primarily founded on its enhancement of seeding of the transferred lymphoid cells, implying that homing of these cells is a prerequisite for their anti-tumor activity.