Kallikrein-kinin system of blood plasma on heterotransfusion backed by the use of heparin.

Experiments were made on 36 adult rabbits and 25 dogs. Heterogenous blood transfusion to the animals was proceded by an injection of heparin. No heparin was given to the control group. The injection of heparin to the experimental animals prior to heterotransfusion decreased lethality and the gravity of posttransfusional reactions. This was accompanied by a mildly expressed activity of the kinin system. The preliminary injection of heparin to animals before transfusion of heteroblood caused an inhibiting effect on the activity of ferments taking part in the formation of vasoactive polypeptides and contributes to preserving one of the regulating mechanisms of the kinin system, the inhibitor of kallikrein.

Lycurim (R-74) in the therapy of chronic lymphocytic leukaemia.

Lycurim was used in the therapy of 41 CLL patients, in 34 a positive clinical effect was found. The effect was marked in cases of CLL associated with autoimmune haemolytic anaemia. The immunodepressive property of Lycurim was confirmed by immunological investigation. It has been shown that the levels of IgG, IgA and IgM fall after Lycurim treatment of CLL patients. At the same time the T-lymphocyte count decreases and a tendency for EAC rosette-forming B-lymphocyte decrease is marked.