[Microrelief of the internal surface of the thoracic duct in dogs (based on scanning electron microscopy data)]. / Mikrorel'ef vnutrennei poverkhnosti grudnogo protoka sobak (po dannym skaniruiushchei élektronnoi mikroskopii).

The investigation has been performed on 17 mature dogs. With the aim to investigate the internal surface of the thoracic duct, the methods of scanning electron microscopy of native, impregnated and corrosive preparations have been used. The analysis of the scannograms obtained demonstrates that the valves of the thoracic ducts are mainly bicuspid, have a typical infundibular form, their cuspides are fused, forming a mesentery-like fold on the duct wall. It plays the main role in ensuring unilateral transport of lymph. The microrelief of the thoracic duct endothelium possesses a rather complex organization. The following relief formations are distinguished in endotheliocytes: 1. nuclei-containing eminence, 2. marginal processes, 3. separate microvilli. The dependence of the microrelief on arrangement of endothelial cells in the valvular area or intervalvular fragments is noted. This is also concerned orientation of endotheliocytes; therefore, predominance of stretched endotheliocytes of the postvalvular fragment can be connected with demonstration of viscous friction force in the lymph stream, that produces deforming and orienting influence on the endotheliocytes.

[Experimental study of the endolymphatic use of gentamycin and klaforan (cefotaxime)]. / Eksperimental'noe izuchenie éndolimfaticheskogo primeneniia gentamitsina i klaforana (tsefotaksima).

Distribution of gentamycin and klaforan in the lymphatic system, blood and cerebrospinal fluid, as well as their effect on lymph node morphology was studied experimentally on 46 dogs. The antibiotics were administered endolymphatically in doses of 1 and 30 mg/kg respectively. The highest levels of gentamycin (200-250 micrograms/ml) and klaforan (up to 1600 micrograms/ml) were detected in the central lymph. The therapeutic levels of the antibiotics in the central persisted for 24 and 72 hours respectively. The antibiotics accumulated mainly in the regional (inguinal and pelvic) lymph nodes, where their high levels were determined for 72 hours. The levels of the antibiotics in the distant (cervical and tracheobronchial) lymph nodes were lower and did not exceed the therapeutic ones. They persisted for 6 and 24 hours respectively. No unfavourable effect of the antibiotics on the structure and cell composition of the lymph nodes was noted. After endolymphatic administration in the above doses the antibiotic levels in the blood serum were close to those observed after administration by the routine routes. After endolymphatic administration in the above doses the antibiotics penetrated into the cerebrospinal fluid.