RESUMO
Objective@# The aim was to compare and document the aesthetic influences on peri-implant soft tissues between the immediate and early implant placement in the aesthetic area. @*Methods @#22 patients with single anterior teeth missing were included and divided into 2 group. Group A (12cases): Following the extraction of teeth, 12 Zimmer implants were immediately placed into sockets. Group B (10 cases): 4~8 weeks after the extraction, 10 Zimmer implants were early placed into the healing sockets. Zirconia crowns were applied on the implants 6 months later after implantation. The peri-implant soft tissues in both group were examined and evaluated by pink esthetic score (PES) 6~12 months later. Analysis of the data was performed by software SPSS 13.0. @*Results @#The mean PES was 9.27 (clinical acceptance) for all of the implants. No significant were found for any of the parameters between the treatment modalities regardness of total PES or single PES. However there were significant differences in the following aspects: the correlation between periodontal disease and papilla, the correlation between gingival biotype and mesial papilla, the correlation between gingival biotype and alveolar process deficiency, the correlation between Implant location and midfacial soft tissue level. @*Conclusion@#There are no significant differences between immediate placement and early placement on the aesthetic outcome of peri-implant soft tissues. The aesthetic outcome are related to patients oral health condition and clinicians skills.
RESUMO
Recent studies have shown that Er-Zhi-Wan (EZW), a traditional Chinese medicine consisting of Herba Ecliptae (HE) and Fructus Ligustri Lucidi (FLL), had a definite antiosteoporotic effect on osteoporotic femur, but its effect on osteoporosis of alveolar bone remains unknown. In the present study, we investigated the effects of Er-Zhi-Wan (EZW) on the microarchitecture and the regulation of Wnt/ß-catenin signaling pathway in the alveolar bone of ovariectomized rats. Thirty Sprague-Dawley rats were randomly divided into three groups: sham operation group (sham, n=10), ovariectomy (OVX) group (n=10), and OVX with EZW treatment group (EZW group, n=10). From one week after ovariectomy, EZW (100 mg/mL) or vehicle (distilled water) was fed (1 mL/100 g) once per day for 12 weeks until the sacrifice of the rats. The body weights were measured weekly. After sacrifice, the sera and mandible were collected and routinely prepared for the measurement of alveolar trabecular microarchitecture, serum levels of E2, bone-specific alkaline phosphatase (BALP) and tartrate-resistant acid phosphatase 5b (TRAP5b), as well as mandibular mRNA expression of Wnt/ß-catenin signaling pathway molecules wnt3a, low-density lipoprotein receptor-related protein 5 (LRP5), ß-catenin and dickkopf homolog 1 (DKK1). The results showed that EZW treatment significantly prevented the body weight gain, degradation of alveolar trabecular microarchitecture and alveolar bone loss in the OVX rats. Furthermore, we observed that EZW could increase the serum levels of E2 and BALP, and decrease levels of serum TRAP5b in EZW group compared with vehicle group. In addition, RT-PCR results revealed that EZW upregulated the expression levels of wnt3a, LRP5 and ß-catenin, and reduced the expression of DKK1 in OVX rats. Taken together, our results suggested that EZW may have potential anti-osteoporotic effects on osteoporotic alveolar bone by stimulating Wnt/LRP5/ß-catenin signaling pathway.