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BACKGROUND: Psychiatric disorders differ in frequency and symptoms based on the cultural and ethnic background of patients. This can make diagnosing and treating patients challenging globally. In Pakistan, most psychiatric patients report multiple somatic complaints. Our goal was to investigate the causes of these complaints, identify common psychiatric conditions, and analyze their various manifestations in clinical practice. We also aimed to identify ways to improve the quality of care provided to our patients. METHODOLOGY: We collected and organized data by utilizing predetermined tables from a sample of 231 patients who visited the outpatient clinics. Inpatients were not included in this study because of the absence of a psychiatric unit at our facility. Patients' past medical and psychiatric records were thoroughly examined, and pertinent information was extracted. The most common psychiatric disorders within the studied population were diagnosed based on the International Classification of Diseases, Tenth Revision (ICD-10) diagnostic criteria. RESULTS: In this study, a sample size of 231 was examined to determine the most common diseases (ICD-10) in males and females. In males, the most prevalent diseases were mixed anxiety and depression (MAD), depression, generalized anxiety disorder (GAD), bipolar affective disorder (BPAD), social phobia, and obsessive-compulsive disorder (OCD). Females, on the other hand, presented more with depression, GAD, mixed anxiety and depression, conversion or dissociative disorder, OCD, and panic attacks. Headaches were the most frequently reported symptom, experienced by 61.9% the of participants, followed by lethargy, extremity pains, palpitations, loss of appetite, heartburn or acidity, heaviness on the head, shoulder pains, bloating, dizziness, chest pains, hot flashes or shivering, and constipation. Meanwhile, a quarter of the males did not complain of any somatic symptoms, compared to 10% of the females. Additionally, 7.3% of females reported more than six somatic symptoms, compared to 5.7% of males. When it came to treatment preferences, 73.6% of the participants preferred medication over psychotherapy and over a combination of both. The Statistical Product and Service Solutions (SPSS) Statistics version 22 (IBM SPSS Statistics, Armonk, NY, USA) was used to conduct a chi-square test of independence to analyze the obtained data. For post hoc analysis of quantitative data (i.e., the number of somatic symptoms reported by participants), one-way analysis of variance (ANOVA) was applied, followed by Tukey's honestly significant difference (HSD) test. CONCLUSIONS: This is the first comprehensive study of its kind for this population and region. It emphasizes that clinicians should be aware of the variety of somatic symptoms and psychiatric presentations among this population. Such awareness can improve clinical practices and reduce the burden on health services.
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The COVID-19 pandemic has affected millions globally. Several studies have been carried out to uncover factors affecting the severity of the resulting infection. Available location-specific data concerning the affective demographics as well as clinical aspect of the disease remains limited. In this study, a number of non-clinical as well as the clinical parameters were investigated for their role in adverse progression of the disease in patients admitted to intensive care unit (ICU) in a private tertiary hospital in Peshawar. The prevalence of comorbidities hypertension and diabetes as well as mortality was higher in age group of 70-79 years. Dyspnea was significantly linked to sepsis, invasive ventilation, and mortality; its late presentation, i.e. 15 to 20 days was significantly associated with mortality (p-value < 0.02). Acute kidney injury and acute respiratory distress syndrome were found to be the most strongly associated with sepsis and septic shock. Neither remdesivir nor tocilizumab was effective in preventing the infection-related complications, invasive ventilation, and mortality. Overall, dyspnea was found to be an indicator of the worst progression of the disease. Furthermore, while some parameters were closely linked, others were not.
Assuntos
COVID-19 , Sepse , Humanos , Idoso , Estudos Retrospectivos , Pandemias , DispneiaRESUMO
Methodology Data were accumulated from all patients seen in outpatient clinics from October to December 2020. No inpatients or community samples were included in the research. Verbal consent and approval from the local ethical committee were obtained beforehand. ICD-10 diagnostic criteria were used for all psychiatric diagnoses. Results A total of 500 patients were seen with a gender distribution of 51% females and 49% males. Patients aged 18-65 years comprised 79% of this sample; 52% had no formal education. A total of 43% lived in settled areas; 37% were from Afghanistan; 13% from tribal areas, and 7% were from the Swat region. Thirty percent had no medical history, and 40% reported no prior contact with psychiatric service. Anxiety spectrum disorders were more prevalent in females, and psychotic and drug-related illnesses were more prevalent in males. More than half the patients seen were considered fit for psychotherapy referral but could not engage because of the lack of such services near their homes. The significance of the results obtained was assessed using the Chi-squared test, using SPSS v.22. A p-value of less than 0.05 was considered significant. Conclusion Almost 40% of patients were admitted due to some form of trauma history, predominantly terrorism-related, displacement, and other losses. Two in three people reported current or past drug use, with tetrahydrocannabinol (THC) being the most commonly used drug, followed by sedatives, opioids/pain relief medications, amphetamines, or methamphetamine (ICE), and others (e.g., alcohol). There was a significant rise in drug use/trauma history in the tribal areas, Afghanistan, and Swat region compared to the local population of settled areas. Common psychiatric illnesses were as expected in the sample studied.
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The global increase in the consumption of antibiotics has resulted in contamination of different ecosystems with severe implications on crop productivity. This study investigated the effects of ampicillin and ofloxacin on Lactuca sativa germination upon solution exposure and growth when cultivated in soils treated with three organic amendments (compost, rice husk and vermicompost). Two levels of both antibiotics 5 and 10 mg L-1 (for solution) or mg kg-1 (for soil) were tested in addition to the control. Results indicated that addition of compost significantly (p < 0.05) increased (50%) the root lengths of plant exposed to ampicillin (5 mg L-1). Similarly, vermicompost-amended treatments displayed a 64% increase (p < 0.05) in the shoot length of seedlings under the effect of 5 mg L-1 ofloxacin, depicting a positive synergistic effect between the antibiotics and amendments in the germination test. Nevertheless, the germination percentage remained unaffected in all the treatments. In greenhouse experiment, enhanced plant biomass was observed with the use of rice husk across all the treatment groups. Comparable to the germination test, plants treated with rice husk and compost signaled a higher content of rubisco large subunit (157% and 85%, respectively) and soluble protein (248% and 108%, respectively) post antibiotics application. On the contrary, an antagonistic effect of the rice husk and ofloxacin 5 mg kg-1 was observed on the chlorophyll content, evident by a 37% decrease. Overall, it was observed that the effect of antibiotics on different plant traits vary depending on the antibiotic concentration as well as type of amendment used.
