Leverabscess utløst av et fiskeben.

BACKGROUND: Liver abscess caused by foreign bodies constitutes a rare medical problem that few of us will encounter in a clinical setting. CASE PRESENTATION: We describe a case where a woman presented with sepsis and abdominal pain. Computed tomography (CT) of her abdomen revealed a large hepatic abscess containing a foreign body. Based on the size, shape and density of the object, a fishbone was suspected. INTERPRETATION: We hypothesise that she swallowed a fishbone, which then perforated the gastrointestinal tract and lodged in the liver. After interdisciplinary discussion it was decided to proceed with conservative management, and the patient was treated successfully with antibiotics for a total of 31 days.

Antitumour necrosis factor alpha treatment in Crohn's disease: long-term efficacy, side effects and need for surgery.

OBJECTIVES: To examine the long-term efficacy and side effects of antitumour necrosis factor alpha (anti-TNF) therapy in patients with Crohn's disease (CD), the need for surgery and the clinical outcome after discontinuing anti-TNF therapy. MATERIAL AND METHODS: Data were collected from the inflammatory bowel disease (IBD)-TNF register at Østfold Hospital Trust. Clinical and sociodemographic data were recorded for patients initiating anti-TNF therapy from January 2000 until December 2011. Follow-up was conducted until December 2017. RESULTS: Complete remission (CR) was achieved in 40/154 (26%) patients at the last follow-up (median follow-up time 10 years). A total of 40 (26%) patients had to discontinue treatment due to serious side effects, and malignancy was recorded in 10 (6.5%) patients. Surgical resection was performed in 55 (36%) patients during follow-up. Patients with Montreal phenotype B2 before anti-TNF therapy were estimated to have a 2.54-fold greater risk of surgery than patients with phenotype B1 (p = .001). Of those with phenotype B1 before anti-TNF therapy, 19 (24%) of them developed stenosis in need of surgical resection ('phenotype migration'). In patients followed up after discontinuing anti-TNF therapy (n = 89, median observational time six years), CR was achieved in most patients. CONCLUSIONS: Long-term complete remission was achieved in only one in four patients receiving anti-TNF therapy, and one in four patients had to discontinue therapy due to side effects. Despite anti-TNF therapy, one in four patients with a baseline luminal disease phenotype needed subsequent surgical resection.

The effect of referral templates on out-patient quality of care in a hospital setting: a cluster randomized controlled trial.

BACKGROUND: The assessment of quality of care is an integral part of modern medicine. The referral represents the handing over of care from the general practitioner to the specialist. This study aimed to assess whether an improved referral could lead to improved quality of care. METHODS: A cluster randomized trial with the general practitioner surgery as the clustering unit was performed. Fourteen surgeries in the area surrounding the University Hospital of North Norway Harstad were randomized stratified by town versus countryside location. The intervention consisted of implementing referral templates for new referrals in four clinical areas: dyspepsia; suspected colorectal cancer; chest pain; and confirmed or suspected chronic obstructive pulmonary disease. The control group followed standard referral practice. Quality of treatment pathway as assessed by newly developed quality indicators was used as main outcome. Secondary outcomes included subjective quality assessment, positive predictive value of referral and adequacy of prioritization. Assessment of outcomes was done at the individual level. The patients, hospital doctors and outcome assessors were blinded to the intervention status. RESULTS: A total of 500 patients were included, with 281 in the intervention and 219 in the control arm. From the multilevel regression model the effect of the intervention on the quality indicator score was insignificant at 1.80% (95% CI, -1.46 to 5.06, p = 0.280). No significant differences between the intervention and the control groups were seen in the secondary outcomes. Active use of the referral intervention was low, estimated at approximately 50%. There was also wide variation in outcome scoring between the different assessors. CONCLUSIONS: In this study no measurable effect on quality of care or prioritization was revealed after implementation of referral templates at the general practitioner/hospital interface. The results were hindered by a limited uptake of the intervention at GP surgeries and inconsistencies in outcome assessment. TRIAL REGISTRATION: The study was registered under registration number NCT01470963 on September 5th, 2011.

Impact of referral templates on patient experience of the referral and care process: a cluster randomised trial.

OBJECTIVES: To evaluate if a referral intervention improves the patient experience of the referral and treatment process. SETTING: Interface between 14 primary care surgeries and a district general hospital. PARTICIPANTS: The 14 general practitioner (GP) surgeries (7 intervention, 7 control) in the area around the University Hospital of North Norway Harstad were randomised and all completed the study. Consecutive individual patients were recruited at their hospital appointment. A total of 500 patients were recruited with 281 in the intervention and 219 in the control arm. INTERVENTIONS: Dissemination of referral templates for 4 diagnostic groups (dyspepsia, suspected colorectal cancer, chest pain and chronic obstructive pulmonary disease) coupled with intermittent surgery visits by study personnel. The control arm continued standard referral practice. The intervention was in use for 2.5 years. OUTCOME: The main outcome was a quality indicator score. This paper reports a secondary outcome, the patient experience, as measured by self-report questionnaires. GPs in the intervention group could not be blinded. Patients were blinded to intervention status. Analysis was based on single-question comparison with a questionnaire subscore used to assess the effect of clustering. RESULTS: On the individual questions, overall satisfaction was very high with minor differences between the intervention and control group. Interestingly, the most negative responses, in both groups concerned questions relating to patient interaction and information. Very little evidence of clustering was found with an estimated intracluster correlations coefficient at 1.21e-11. CONCLUSIONS: In total, this indicates no clear effect of the implementation of referral templates on the patient experience, in a setting of generally high patient satisfaction. TRIAL REGISTRATION NUMBER: NCT01470963; Results.

Impact of referral templates on the quality of referrals from primary to secondary care: a cluster randomised trial.

BACKGROUND: The referral letter is an important document facilitating the transfer of care from a general practitioner (GP) to secondary care. Hospital doctors have often criticised the quality and content of referral letters, and the effectiveness of improvement efforts remains uncertain. METHODS: A cluster randomised trial was conducted using referral templates for patients in four diagnostic groups: dyspepsia, suspected colorectal cancer, chest pain and chronic obstructive pulmonary disease. The GP surgery was the unit of randomisation. Of the 14 surgeries served by the University Hospital of North Norway Harstad, seven were randomised to the intervention group. Intervention GPs used referral templates soliciting core clinical information when initiating a new referral in one of the four clinical areas. Intermittent surgery visits by study personnel were also carried out. A total of 500 patients were included, with 281 in the intervention and 219 in the control arm. Referral quality scoring was performed by three blinded raters. Data were analysed using multi-level regression modelling. All analyses were conducted on intention-to-treat basis. RESULTS: In the final multilevel model, referrals in the intervention group scored 18% higher (95% CI (11%, 25%), p < 0.001) on the referral quality score than the control group. The model also showed that board certified GPs and GPs in larger surgeries produced referrals of significantly higher quality. CONCLUSION: In this study, the dissemination of referral templates coupled with intermittent surgery visits produced higher quality referrals. TRIAL REGISTRATION: This trial has been registered at ClinicalTrials.gov. The trial registration number is NCT01470963.

Community-based rehabilitation and the Clubhouse Model as means to recovery and mental health services reform / Rehabilitación basada en la comunidad y el modelo Clubhouse como medio de recuperación y reforma de los servicios de salud mental

The article focuses on the trends of community-based rehabilitation (CBR) and the psychosocial Clubhouse rehabilitation model (CH) as tools for mental health (MH) policy reforms. It is based on documentation of the transnational project ôEmpowering Adults with Mental Illness for Learning and Social Inclusion in the years 2010-2012õ and other sources. The collection of data and subsequent analysis were prepared in the context of about 30 international MH policy recommendations from the 1990s until 2012. The documents were analyzed and compared with different recovery-oriented approaches like the CH model and with the key concepts of rehabilitation science, linked with the recent trends of the psychosocial rehabilitation. Some of the most important intergovernmental MH policy recommendations are the United Nations (UN) Convention on Rights of People with Disabilities (CRPD, UN 2006), the joint CBR û Guidelines of the WHO (2010), ILO, UNESCO and several international associations as the WAPR (WAPR & WHO Consensus Statement 1996), as well as the WHO Pyramid Framework for the Optimal mix of MH services (WHO 2007), complemented with the WHOÆs Comprehensive MH Action Plan 2013-2020 approved in May 2013. All these sources include the spectrum of MH disorders. The combining factors are the human rights û based on a more holistic understanding of the disabilities instead of a merely medical approach. All the above recommendations are aimed at worldwide utilization.

Se examinan las tendencias de rehabilitación basada en la comunidad (CBR) y el modelo de rehabilitación psicosocial denominado Clubhouse (CH) como instrumentos de políticas de reforma de la Salud Mental (MH). El trabajo se basa en documentación del proyecto transnacional ôEmpoderamiento de adultos con enfermedad mental para aprendizaje e inclusión social en 2010-2012õ además de otras fuentes. La colección de datos y subsecuentes análisis se prepararon en el contexto de cerca de 30 recomendaciones internacionales de políticas de salud mental desde los años 90 hasta el 2012. Los documentos fueron analizados y comparados con diferentes enfoques orientados a la recuperación, tales como el modelo CH, y con conceptos clave de la ciencia de Rehabilitación, vinculados con tendencias recientes de la rehabilitación psicosocial. Algunas de las más importantes recomendaciones intergubernamentales de políticas de salud mental son las Guías conjuntas de Trabajo de la Organización Mundial de la Salud (OMS) y UNESCO y varias asociaciones internacionales tales como la Asociación Mundial de Rehabilitación Psiquiátrica (WAPR) y el Marco Piramidal de la OMS para la óptima combinación de servicios de Salud Mental, complementados con el Plan Integral de Acción en Salud Mental 2013-2020 aprobado por la OMS este año. Todas estas fuentes incluyen el espectro total de trastornos mentales. Factores de combinación son los derechos humanos, basados en una comprensión más holística de las discapacidades en lugar de un enfoque meramente médico. Todas estas recomendaciones están orientadas a su utilización a nivel global.

Practical health co-operation - the impact of a referral template on quality of care and health care co-operation: study protocol for a cluster randomized controlled trial.

BACKGROUND: The referral letter plays a key role both in the communication between primary and secondary care, and in the quality of the health care process. Many studies have attempted to evaluate and improve the quality of these referral letters, but few have assessed the impact of their quality on the health care delivered to each patient. METHODS: A cluster randomized trial, with the general practitioner office as the unit of randomization, has been designed to evaluate the effect of a referral intervention on the quality of health care delivered. Referral templates have been developed covering four diagnostic groups: dyspepsia, suspected colonic malignancy, chest pain, and chronic obstructive pulmonary disease. Of the 14 general practitioner offices primarily served by University Hospital of North Norway Harstad, seven were randomized to the intervention group. The primary outcome is a collated quality indicator score developed for each diagnostic group. Secondary outcomes include: quality of the referral, health process outcome such as waiting times, and adequacy of prioritization. In addition, information on patient satisfaction will be collected using self-report questionnaires. Outcome data will be collected on the individual level and analyzed by random effects linear regression. DISCUSSION: Poor communication between primary and secondary care can lead to inappropriate investigations and erroneous prioritization. This study's primary hypothesis is that the use of a referral template in this communication will lead to a measurable increase in the quality of health care delivered. TRIAL REGISTRATION: This trial has been registered at ClinicalTrials.gov. The trial registration number is NCT01470963.

Partnerships for better mental health worldwide: WPA recommendations on best practices in working with service users and family carers.

WPA President M. Maj established the Task Force on Best Practice in Working with Service Users and Carers in 2008, chaired by H. Herrman. The Task Force had the remit to create recommendations for the international mental health community on how to develop successful partnership working. The work began with a review of literature on service user and carer involvement and partnership. This set out a range of considerations for good practice, including choice of appropriate terminology, clarifying the partnership process and identifying and reducing barriers to partnership working. Based on the literature review and on the shared knowledge in the Task Force, a set of ten recommendations for good practice was developed. These recommendations were the basis for a worldwide consultation of stakeholders with expertise as service users, families and carers, and the WPA Board and Council. The results showed a strong consensus across the international mental health community on the ten recommendations, with the strongest agreement coming from service users and carers. This general consensus gives a basis for Task Force plans to seek support for activities to promote shared work worldwide to identify best practice examples and create a resource to assist others to begin successful collaboration.

Prospective, double-blind, randomized, placebo-controlled comparison of acetazolamide versus ibuprofen for prophylaxis against high altitude headache: the Headache Evaluation at Altitude Trial (HEAT).

OBJECTIVE: High altitude headache (HAH) is the most common neurological complaint at altitude and the defining component of acute mountain sickness (AMS). However, there is a paucity of literature concerning its prevention. Toward this end, we initiated a prospective, double-blind, randomized, placebo-controlled trial in the Nepal Himalaya designed to compare the effectiveness of ibuprofen and acetazolamide for the prevention of HAH. METHODS: Three hundred forty-three healthy western trekkers were recruited at altitudes of 4280 m and 4358 m and assigned to receive ibuprofen 600 mg, acetazolamide 85 mg, or placebo 3 times daily before continued ascent to 4928 m. Outcome measures included headache incidence and severity, AMS incidence and severity on the Lake Louise AMS Questionnaire (LLQ), and visual analog scale (VAS). RESULTS: Two hundred sixty-five of 343 subjects completed the trial. HAH incidence was similar when treated with acetazolamide (27.1%) or ibuprofen (27.5%; P = .95), and both agents were significantly more effective than placebo (45.3%; P = .01). AMS incidence was similar when treated with acetazolamide (18.8%) or ibuprofen (13.7%; P = .34), and both agents were significantly more effective than placebo (28.6%; P = .03). In fully compliant participants, moderate or severe headache incidence was similar when treated with acetazolamide (3.8%) or ibuprofen (4.7%; P = .79), and both agents were significantly more effective than placebo (13.5%; P = .03). CONCLUSIONS: Ibuprofen and acetazolamide were similarly effective in preventing HAH. Ibuprofen was similar to acetazolamide in preventing symptoms of AMS, an interesting finding that implies a potentially new approach to prevention of cerebral forms of acute altitude illness.

The higher incidence of squamous cell carcinoma in renal transplant recipients is associated with increased telomere lengths.

The incidence and aggressiveness of nonmelanoma skin cancers, including basal cell carcinoma and squamous cell carcinoma (SCC), in immunocompromised renal transplant recipients (RTRs) is dramatically higher (up to 100-fold) compared with the normal population. SCC lesions are also predominant in RTRs, in contrast to the normal population where basal cell carcinoma is more common. The mechanisms underlying this phenomenon are unknown, but effective treatments for these skin tumors would have a significant impact upon morbidity in this group of patients. The fundamental role of telomeres and telomerase in the development of most human cancers, including melanoma, is well established, but very few reports have assessed their function during the onset of nonmelanoma skin cancer. To assess whether telomere maintenance plays any role in the increased incidence of SCC in renal transplant patients, we analyzed both the telomere lengths and telomerase expression levels in 44 SCCs and 22 Bowen's disease (BD) samples (carcinoma in situ) from RTRs and nontransplant patients. Our findings provide statistically significant evidence that the telomeres are consistently longer in both BD RTR and SCC RTR lesions compared with their nontransplant counterparts. We also show by immunohistochemistry that there is a trend toward higher telomerase levels in both the BD RTR and SCC RTR lesions, although this was not statistically significant. Our data thus suggest that telomere lengthening may possibly be an early event in the development of SCC in renal transplant patients and demonstrate that telomere maintenance mechanisms should be further evaluated with respect to developing a future therapeutic strategy for these cancers.