[Chronic gastritis and ulcer disease in young men]. / Przewlekle zapalenie blony sluzowej zoladka, a choroba wrzodowa u mlodych mezczyzn.

Examination has been carried out on 34 young men (average age: 22 years) with chronic erosive gastritis. Chronic erosions were situated most frequently in the prepyloric part of the stomach (88.2%). Duodenal ulcer-was found in 14 patients (41.1%), gastric ulcer was found in 1 patient (2.9%). In 19 examined patients (56.0%) chronic erosive gastritis existed without any other disease of the gastrointestinal tract. Clinical picture, gastric secretion and histopatological examination were compared in two group: I-chronic erosive gastritis without any other changes within the gastrointestinal tract and group II-chronic erosive gastritis coexisting with duodenal ulcer in the clinical picture of the group I, pain usually occurred after a meal and was felt as a heaviness sensation in epigastrum, while in the group II patients felt suction, hunger pain night pain and heartburn. Gastric secretion in the two group did not differ much. Microscopic examination of the mucosa usually confirmed chronic active gastritis. A typical feature for both group was regenerative glandular hyperplasia of the gastric mucosa. Despite many common features, it is impossible to identify explicitly and univocally the relationship between chronic erosive gastritis and ulceration.

Chronic erosive gastritis on morphological analysis.

The present study was carried out to systematize the histopathological markers of chronic erosive gastritis referred to also as gastritis varioliformis (GV). The study population consisted of 74 patients aged 20 to 69 years with gastroscopic GV. The samples were obtained from the erosion site and representative areas of the prepyloric region and gastric body. In routine microscopic examinations we evaluated the severity, type and location of changes in the gastric mucosa. Helicobacter pylori in tissue samples was identified with Giemsa's staining. Gastroscopic GV is accompanied in 76% by microscopic gastritis. In the vicinity of GV the gastric mucosa shows inflammation signs but less severe. Regenerative glandular hyperplasia of the gastric pit layer is the most frequent microscopic marker of GV.

[Comparative evaluation of sucralfate (Venter) and cimetidine (Altramet) efficiency in treatment of chronic erosive gastritis]. / Porównawcza ocena skutecznosci sukralfatu (Venter) i cymetydyny (Altramet) w leczeniu przewleklego nadzerkowego zapalenia zoladka.

The results of patients with chronic erosive gastritis treated with sucralfate (Venter) and cimetidine (Altramet) were compared. 50 patients were treated with 4.0 g of sucralfate daily and 42 patients with 1000 mg of cimetidine daily. After 4 weeks of treatment endoscopic assessment of 13 patients (26.0%) treated with sucralfate and 5 patients (11.6%) treated with cimetidine was normal. It was possible to heal only the erosions of 33 (66.0%) and 17 (40.5%) patients respectively, while the mucosal elevations remained. The result of examinations indicate, that chronic erosive gastritis is difficult to be healed; sucralfate proved to be more efficient than cimetidine.

Comparative studies on the effect of hemoperfusion and hemodialysis on the elimination of some uremic toxins.

This study, performed on patients with terminal renal failure, compares the changes in plasma concentrations of middle molecules, myoinositol, low molecular weight metabolites, and blood components during 4 hour periods of hemodialysis and hemoperfusion over a charcoal cartridge. After hemoperfusion there is a more marked decrease of adsorbable substances such as middle molecules, creatinine, and uric acid, whereas after hemodialysis there is a greater change in serum concentrations of myoinositol, urea, and electrolytes. The findings show that although hemoperfusion over a charcoal cartridge cannot replace hemodialysis in the treatment of chronic renal failure, it is effective as a complementary method, because of the better removal of some uremic toxins.