Zirconia aerogels for thermal management: Review of synthesis, processing, and properties information architecture.

Zirconia aerogels are porous nanomaterials with high specific surface areas and low thermal conductivities that are suitable for a wide range of functions. The applications of zirconia aerogels include numerous uses in thermal management systems that are specifically beneficial in aeronautics and aerospace systems. This review seeks to detail the synthesis, processing, and characterization of these unique materials. However, the many distinctive synthesis pathways and processing conditions of zirconia aerogels can make the optimization of these materials difficult, potentially inhibiting further development. Independent variables in the synthesis process alone include zirconium precursor, rare earth stabilizer, solvent system, gelation agent, and surfactant templating agent. If only two distinct options were available for each synthetic variable, there would be up to 32 different synthetic pathways; if there were three options for each variable, 243 different synthetic pathways would be possible. Apart from the gel synthesis, processing conditions, including drying method, drying temperature, drying solvent, and sintering temperature, as well as various techniques used to characterize aerogels, need to be considered. To mitigate the sheer volume of synthetic parameters, this review uses an architected information structure to contemplate approximately 600 aerogel materials, along with the synthesis and processing conditions that make each material unique. By utilizing this information structure, containing over 10,000 relationships amongst 3,800 nodes, the connection between specific properties of zirconia aerogels and the pathways used to produce them can be more easily visualized, leading to a more effective understanding of the many variables that are used in the synthesis and processing of these materials. This review seeks to utilize data science in a way that can elucidate structure-property relationships in colloidal chemistry, providing a more efficient way to evaluate the synthesis and processing of materials with high experimental dimensionality.

Rapid, Single-Step Protein Encapsulation via Flash NanoPrecipitation.

Flash NanoPrecipitation (FNP) is a rapid method for encapsulating hydrophobic materials in polymer nanoparticles with high loading capacity. Encapsulating biologics such as proteins remains a challenge due to their low hydrophobicity (logP < 6) and current methods require multiple processing steps. In this work, we report rapid, single-step protein encapsulation via FNP using bovine serum albumin (BSA) as a model protein. Nanoparticle formation involves complexation and precipitation of protein with tannic acid and stabilization with a cationic polyelectrolyte. Nanoparticle self-assembly is driven by hydrogen bonding and electrostatic interactions. Using this approach, high encapsulation efficiency (up to ~80%) of protein can be achieved. The resulting nanoparticles are stable at physiological pH and ionic strength. Overall, FNP is a rapid, efficient platform for encapsulating proteins for various applications.

Single-Step Self-Assembly and Physical Crosslinking of PEGylated Chitosan Nanoparticles by Tannic Acid.

Chitosan-based nanoparticles are promising materials for potential biomedical applications. We used Flash NanoPrecipitation as a rapid, scalable, single-step method to achieve self-assembly of crosslinked chitosan nanoparticles. Self-assembly was driven by electrostatic interactions, hydrogen bonding, and hydrophobic interactions; tannic acid served to precipitate chitosan to seed nanoparticle formation and crosslink the chitosan to stabilize the resulting particles. The size of the nanoparticles can be tuned by varying formulation parameters including the total solids concentration and block copolymer to core mass ratio. We demonstrated that hydrophobic moieties can be incorporated into the nanoparticle using a lipophilic fluorescent dye as a model system.