A compact pulsed power driver with precisely shaped current waveforms for magnetically driven loading experiments.

Magnetically driven loading techniques based on high current pulsed power drivers are very important tools for researching material dynamic behaviors and high-pressure physics. Based on the technologies of a Marx generator energy storage and low impedance coaxial cable energy transmission, a compact high current pulsed power driver CQ-7 was developed and established at the Institute of Fluid Physics, China Academy of Engineering Physics, which can generate precisely shaped current waveforms for magnetically driven loading experiments. CQ-7 is composed of 256 two-stage Marx generators in parallel with low impedance, high voltage coaxial cables for current output. The 256 Marx generators are divided into 16 groups, and each separate group can be individually triggered to discharge and shape currents in sequence by a low jitter, high voltage pulse trigger with 16 output signals. The electrical parameters of CQ-7 are a capacitance of 20.48 µF, an inductance of 4.12 nH, and a resistance of 3.35 mΩ in a short circuit. When working at the charging voltage of ±40-±60 kV, CQ-7 can deliver a peak current from 5 to 7 MA to the short-circuit loads with a rising time of 400-700 ns at different discharging time sequences. Two different experiments were conducted to test the performance of CQ-7: magnetically driven high velocity flyer plates and solid liner implosion. The results show that CQ-7 can accelerate the aluminum flyer plate with a size of 12 × 8 × 1 mm3 to more than 7.5 km/s and uniformly drive the aluminum liner with an inner diameter of 6.2 mm and a thickness of 0.4 mm to more than 9.5 km/s. Furthermore, these experiments indicate that CQ-7 is a robust platform for material dynamics and high-pressure physics.

A compact platform for the investigation of material dynamics in quasi-isentropic compression to ~ 19 GPa.

This paper reports on the development of a magnetically driven high-velocity implosion experiment conducted on the CQ-3 facility, a compact pulsed power generator with a load current of 2.1 MA. The current generates a high Lorentz force between inner and outer liners made from 2024 aluminum. Equally positioned photonic Doppler velocimetry probes record the liner velocities. In experiment CQ3-Shot137, the inner liner imploded with a radial converging velocity of 6.57 km/s while the outer liner expanded at a much lower velocity. One-dimensional magneto-hydrodynamics simulation with proper material models provided curves of velocity versus time that agree well with the experimental measurements. Simulation then shows that the inner liner underwent a shock-less compression to approximately 19 GPa and reached an off-Hugoniot high-pressure state. According to the scaling law that the maximum loading pressure is proportional to the square of the load current amplitude, the results demonstrate that such a compact capacitor bank as CQ-3 has the potential to generate pressure as high as 100 GPa within the inner liner in such an implosion experiment. It is emphasized that the technique described in this paper can be easily replicated at low cost.

A high current pulsed power generator CQ-3-MMAF with co-axial cable transmitting energy for material dynamics experiments.

A high current pulsed power generator CQ-3-MMAF (Multi-Modules Assembly Facility, MMAF) was developed for material dynamics experiments under ramp wave and shock loadings at the Institute of Fluid Physics (IFP), which can deliver 3 MA peak current to a strip-line load. The rise time of the current is 470 ns (10%-90%). Different from the previous CQ-4 at IFP, the CQ-3-MMAF energy is transmitted by hundreds of co-axial high voltage cables with a low impedance of 18.6 mΩ and low loss, and then hundreds of cables are reduced and converted to tens of cables into a vacuum chamber by a cable connector, and connected with a pair of parallel metallic plates insulated by Kapton films. It is composed of 32 capacitor and switch modules in parallel. The electrical parameters in short circuit are with a capacitance of 19.2 µF, an inductance of 11.7 nH, a resistance of 4.3 mΩ, and working charging voltage of 60 kV-90 kV. It can be run safely and stable when charged from 60 kV to 90 kV. The vacuum of loading chamber can be up to 10(-2) Pa, and the current waveforms can be shaped by discharging in time sequences of four groups of capacitor and switch modules. CQ-3-MMAF is an adaptive machine with lower maintenance because of its modularization design. The COMSOL Multi-physics® code is used to optimize the structure of some key components and calculate their structural inductance for designs, such as gas switches and cable connectors. Some ramp wave loading experiments were conducted to check and examine the performances of CQ-3-MMAF. Two copper flyer plates were accelerated to about 3.5 km/s in one shot when the working voltage was charged to 70 kV. The velocity histories agree very well. The dynamic experiments of some polymer bonded explosives and phase transition of tin under ramp wave loadings were also conducted. The experimental data show that CQ-3-MMAF can be used to do material dynamics experiments in high rate and low cost shots. Based on this design concept, the peak current of new generators can be increased to 5-6 MA and about 100 GPa ramp stress can be produced on the metallic samples for high pressure physics, and a conceptual design of CQ-5-MMAF was given.

High velocity flyer plates launched by magnetic pressure on pulsed power generator CQ-4 and applied in shock Hugoniot experiments.

High velocity flyer plates with good flatness and some thickness have being widely used to the field of shock physics for characterizations of materials under dynamical loading. The techniques of magnetically driven high-velocity flyer plates are further researched based on our pulsed power generators CQ-4 and some good results got on Sandia's Z machine. With large current of several mega-amperes, the loading surface of electrode panel will suffer acute phase transitions caused from magnetic diffusion and Joule heating, and the thickness and flatness of the flyer plates will change with time. In order to obtain the flyer plates with high performances for shock physics, some researches on electrode panels were done by means of LS-DYNA980 software with electro-magnetic package. Two typical configurations for high velocity flyer plates were compared from distribution uniformity of magnetic field in simulation. The results show that the configuration with counter-bore with "notch" and "ear" is better than the other. Then, with the better configuration panels, some experiments were designed and done to validate the simulation results and obtain high velocity flyer plates with good flatness for one-dimensional strain shock experiments on CQ-4. The velocity profiles of the flyer plates were measured by displacement interferometer systems for any reflectors. And the planarity of flyer plates was measured by using the optical fiber pins array for recording the flyer arrival time. The peak velocities of 8.7 km/s with initial dimension of 10 × 7.2 × 0.62 mm for aluminum flyer plates have been achieved. And the flyer plate with initial size of 12 × 9.2 × 0.73 mm was accelerated to velocity of 6.5 km/s with the flatness of less than 11 ns in the central region of 6 mm in diameter and the effective thickness of about 0.220 mm. Based on these work, the symmetrical impact experiments were performed to obtain the high accuracy Hugoniot data of OFHC (oxygen free high conductance) copper on CQ-4. The experimental results agree well with previous experiment's data given by Mcqueen and Marsh [J. Appl. Phys. 31, 1253 (1960)] and Mitchell and Nellis [J. Appl. Phys. 52, 3363 (1981)], and the experimental uncertainty of shock wave velocity is less than 2.4%.

A 4 MA, 500 ns pulsed power generator CQ-4 for characterization of material behaviors under ramp wave loading.

A pulsed power generator CQ-4 was developed to characterize dynamic behaviors of materials under ramp wave loading, and to launch high velocity flyer plates for shock compression and hypervelocity impact experiments of materials and structures at Institute of Fluid Physics, China Academy of Engineering Physics. CQ-4 is composed of twenty capacitor and primary discharge switch modules with total capacitance of 32 µF and rated charging voltage of 100 kV, and the storage energy is transmitted by two top and bottom parallel aluminum plates insulated by twelve layers of polyester film with total thickness of 1.2 mm. Between capacitor bank and chamber, there are 72 peaking capacitors with total capacitance of 7.2 µF and rated voltage of 120 kV in parallel, which are connected with the capacitor bank in parallel. Before the load, there is a group of seven secondary self-breaking down switches connected with the total circuit in series. The peaking capacitors and secondary switches are used to shape the discharging current waveforms. For short-circuit, the peak current of discharging can be up to 3 ~ 4 MA and rise time varies from 470 ns to 600 ns when the charging voltages of the generator are from 75 kV to 85 kV. With CQ-4 generator, some quasi-isentropic compression experiments under ramp wave loadings are done to demonstrate the ability of CQ-4 generator. And some experiments of launching high velocity flyer plates are also done on CQ-4. The experimental results show that ramp wave loading pressure of several tens of GPa on copper and aluminum samples can be realized and the velocity of aluminum flyer plate with size of 10 mm × 6 mm × 0.35 mm can be accelerated to about 11 km/s and the velocity of aluminum flyer plate with size of 10 mm × 6 mm × 0.6 mm can be up to about 9 km/s, which show that CQ-4 is a good and versatile tool to realize ramp wave loading and shock compression for shock physics.

The techniques of metallic foil electrically exploding driving hypervelocity flyer to more than 10 km/s for shock wave physics experiments.

Electrical explosion of metallic foil or wire is widely used to the fields of material science (preparation of nao-meter materials), dynamics of materials, and high energy density physics. In this paper, the techniques of gaining hypervelocity flyer driven by electrical explosion of metallic foil were researched, which are used to study dynamics of materials and hypervelocity impact modeling of space debris. Based on low inductance technologies of pulsed storage energy capacitor, detonator switch and parallel plate transmission lines with solid films insulation, two sets of experimental apparatuses with storage energy of 14.4 kJ and 40 kJ were developed for launching hypervelocity flyer. By means of the diagnostic technologies of velocity interferometer system for any reflectors and fibre-optic pins, the hypervelocity polyester (Mylar) flyers were gained. For the apparatus of 14.4 kJ, flyer of diameter φ6 ~ φ10 mm and thickness of 0.1 ~ 0.2 mm was accelerated to the hypervelocity of 10 ~ 14 km/s. And for the apparatus of 40 kJ, flyer of diameter φ20 ~ 30 mm and thickness of 0.2 mm was launched to the velocity of 5 ~ 8 km/s. The flatness of the flyer is not more than 34 ns for the flyer with diameter of 20 mm, and less than 22 ns for the flyer with diameter of 10 mm. Based on the Lagrange hydrodynamic code, one dimensional simulation was done by introducing database of equation of states, discharging circuit equation and Joule heat equation, and modifying energy equation. The simulation results are well agreed with the experimental results in accelerating processing. The simulation results can provide good advices in designing new experiments and developing new experimental devices. Finally, some experiments of materials dynamics and hypervelocity impact of space debris were done by using the apparatus above. The results show that the apparatus of metallic foil electrically exploding driving hypervelocity flyer is a good and versatile tool for shock dynamics.

The compact capacitor bank CQ-1.5 employed in magnetically driven isentropic compression and high velocity flyer plate experiments.

Based on the low inductance capacitor, the parallel-plate transmission line, and the explosive network closing switch, a compact pulsed power generator CQ-1.5 has been developed at the Institute of Fluid Physics and is capable to deliver a current of peak of 1.5 MA within rise time of 500-570 ns into a 2-3 nH inductive load. The work is motivated to do isentropic compression experiments (ICEs) on metals up to 30-50 GPa and to launch flyer plates at velocities over 8 kms. The experiments were conducted with the diagnostics of both Doppler pin system and velocity interferometer system for any reflectors, and the measured free surface velocity histories of ICE samples were treated with a backward integration code. The results show that the isentropes of Cu and Al samples under 35 GPa are close to their Hugoniots within a deviation of 3%. The LY12 aluminum flyer plates were accelerated to a velocity over 8.96 kms.

[Nedaplatin combined with tegafur in the treatment for advanced esophageal cancer].

OBJECTIVE: To investigate the efficacy and toxicity of nedaplatin combined with tegafur in the treatment for patients with advanced esophageal cancer. METHODS: Among the 65 patients with advanced esophageal cancer, 27 had no history of prior chemotherapy and the other 38 had ever received postoperative adjuvant chemotherapy before. The median age of those cases was 58.0 years. Nedaplatin was given daily by intravenous infusion at a dose of 20 mg/m(2) for 2 hours and tegafur at a dose of 500 mg/m(2) for 8 hours on D1 approximately D5, every 21 days as a cycle. RESULTS: 193 cycles of chemotherapy were accomplished in the 65 patients, and 63 patients were evaluable for response evaluation. Of 27 patients with no prior history of chemotherapy, 6 achieved complete response and 16 partial response, with a response rate (CR + PR) of 81.5%. Among the 36 patients who had ever received postoperative adjuvant chemotherapy, 6 obtained complete response and 10 partial response with a response rate (CR + PR) of 44.4%. The overall median time to tumor progression in this series was 5.6 months. The overall median actuarial survival was 9.3 months, and the one-year survival rate was 24.9%. Nausea and vomiting were the major toxicities, but were mild and well tolerable. Grade 3 to 4 neutropenia was only observed in two patients (3.2%). CONCLUSION: The regimen of nedaplatin combined with tegafur is effective and tolerable for the treatment of advanced esophageal cancer.

[Determination of sulfamethazine and sulfamethoxazole in muscle of chicken by high performance liquid chromatography].

Sulfamethazine and sulfamethoxazole in muscle of chicken was extracted by mixture of acetonitrile and chloroform. After being clean up, they were determined by C18 column using HPLC at 270 nm. The liquid of 0.01 mol/L phosphate buffer:methanol:acetic acid (75.9:23:1.1) was used as the mobile phase. The recovery of sulfamethazine was 74.7%-86.5%. The RSD was 3.6%-7.9%. The recovery of sulfamethoxazole was 74.7-86.5%. The R.S.D was 3.5%-7.9%.