Wavelength-tunable spatiotemporal mode-locking in a large-mode-area Er:ZBLAN fiber laser at 2.8†µm.

We report a tunable spatiotemporally mode-locked large-mode-area Er:ZBLAN fiber laser based on the nonlinear polarization rotation technique. A diffraction grating is introduced to select the operating wavelength. Under the spectral and spatial filtering effects provided by the grating and spatial coupling respectively, stable ps-level spatiotemporally mode-locked pulses around 2.8 µm with a repetition rate of 43.4 MHz are generated. Through a careful adjustment of the grating, a broad wavelength tuning range from 2747 to 2797 nm is realized. To the best of our knowledge, this is the first wavelength-tunable spatiotemporally mode-locked fiber laser in the mid-infrared region.

HHCDB: a database of human heterochromatin regions.

Heterochromatin plays essential roles in eukaryotic genomes, such as regulating genes, maintaining genome integrity and silencing repetitive DNA elements. Identifying genome-wide heterochromatin regions is crucial for studying transcriptional regulation. We propose the Human Heterochromatin Chromatin Database (HHCDB) for archiving heterochromatin regions defined by specific or combined histone modifications (H3K27me3, H3K9me2, H3K9me3) according to a unified pipeline. 42 839 743 heterochromatin regions were identified from 578 samples derived from 241 cell-types/cell lines and 92 tissue types. Genomic information is provided in HHCDB, including chromatin location, gene structure, transcripts, distance from transcription start site, neighboring genes, CpG islands, transposable elements, 3D genomic structure and functional annotations. Furthermore, transcriptome data from 73 single cells were analyzed and integrated to explore cell type-specific heterochromatin-related genes. HHCDB affords rich visualization through the UCSC Genome Browser and our self-developed tools. We have also developed a specialized online analysis platform to mine differential heterochromatin regions in cancers. We performed several analyses to explore the function of cancer-specific heterochromatin-related genes, including clinical feature analysis, immune cell infiltration analysis and the construction of drug-target networks. HHCDB is a valuable resource for studying epigenetic regulation, 3D genomics and heterochromatin regulation in development and disease. HHCDB is freely accessible at http://hhcdb.edbc.org/.

All-polarization-maintaining Ho-doped fiber oscillator mode-locked with nonlinear polarization evolution.

We report a self-starting mode-locked all-polarization-maintaining (PM) holmium (Ho)-doped fiber oscillator operating at ∼2.08 µm based on nonlinear polarization evolution (NPE). The oscillator is configured as a linear cavity structure with two output ports exhibiting completely different pulse characteristics. One output port of the oscillator can deliver a stable, clean soliton-like pulse with a pulse duration of 439 fs and an average power of 7.5 mW at a fundamental repetition rate of 61.67 MHz. In contrast, the other port delivers a low-quality pulse with a complex structure. Numerical simulations reveal that the pulse difference between the two ports is mainly caused by the nonlinear optical interactions between the slow-axis and fast-axis modes in the PM fibers. Furthermore, the obtained clean pulses show significant improvements in relative intensity noise and power stability compared to complex pulses. Our study can help researchers obtain high-quality, stable pulses from PM-NPE mode-locked fiber oscillators.

Frequency-domain-resolved investigation of unitary h-shaped pulses.

We experimentally investigate the generation of h-shaped pulse in an all-polarization-maintaining (PM) and all-normal-dispersion (ANDi) mode-locked fiber laser. The generated pulse is demonstrated to be a unitary pulse, instead of a noise-like pulse (NLP). Furthermore, by employing an external filtering system, the obtained h-shaped pulse can be resolved into rectangular-shaped pulses, chair-like pulses, and Gaussian pulses. The authentic AC traces with a double-scale structure of unitary h-shaped pulses and chair-like pulses are observed on the autocorrelator. The chirp of h-shaped pulses is also proved similar to that of DSR pulses. To the best of our knowledge, this is the first time that the existence of unitary h-shaped pulse generation has been confirmed. Moreover, our experimental results reveal the close relationship of formation mechanisms of dissipative soliton resonance (DSR) pulses, h-shaped pulses, and chair-like pulses, which helps to unify the essences of such "DSR-like" pulses.

976†nm all-polarization-maintaining mode-locked fiber laser based on nonlinear polarization evolution.

An all-polarization-maintaining (PM) mode-locked fiber laser based upon nonlinear polarization evolution (NPE) that operates around 976 nm is presented. The NPE-based mode-locking is realized using a special section of the laser which comprises three pieces of PM fibers with specific deviation angles between the polarization axes and a polarization-dependent isolator. By optimizing the NPE section and adjusting the pump power, dissipative soliton (DS) pulses with a pulse duration of ∼6 ps, a spectral bandwidth of >10 nm and a maximum pulse energy of 0.54 nJ are generated. Self-starting, steady mode-locking operation is achievable within a pump power range of ∼2 W. Moreover, by incorporating a segment of passive fiber into the appropriate location in the laser resonator, an intermediate regime between stable single-pulse mode-locking and noise-like pulse (NLP) is realized in the laser. Our work expands the dimension of the research on the mode-locked Yb-doped fiber laser operating around 976 nm.

All-fiber 3.4-W 2.8-µm ultra-short pulse MOPA system seeded by the soliton self-frequency shift of 2-µm pulses.

We report an all-fiber 2.8-µm ultra-short pulse master oscillator power amplifier (MOPA) system seeded by a soliton self-frequency shift from a mode-locked thulium-doped fiber laser. This all-fiber laser source delivers 2.8-µm pulses with an average power of 3.42 W, a pulse width of 115 fs, and a pulse energy of 45.4 nJ. We demonstrate, to the best of our knowledge, the first femtosecond watt-level all-fiber 2.8-µm laser system. A 2.8-µm pulse seed was obtained via the soliton self-frequency shift of 2-µm ultra-short pulses in a cascaded silica and passive fluoride fiber. A novel, to the best of our knowledge, high-efficiency and compact home-made end-pump silica-fluoride fiber combiner was fabricated and used in this MOPA system. Nonlinear amplification of the 2.8-µm pulse was realized, and soliton self-compression was observed accompanied by spectral broadening.

High-energy femtosecond pulse generation from a hybrid mode-locked large-mode-area Er:ZBLAN fiber laser.

We report a hybrid mode-locked fiber laser at 2.8 µm based on a large-mode-area Er:ZBLAN fiber. Reliable self-starting mode-locking is achieved via the combination of nonlinear polarization rotation and a semiconductor saturable absorber. Stable mode-locked pulses with a pulse energy of 9.4 nJ and a pulse duration of 325 fs are generated. To the best of our knowledge, this is the highest pulse energy directly generated from a femtosecond mode-locked fluoride fiber laser (MLFFL) to date. The measured M2 factors are below 1.13, indicating a nearly diffraction-limited beam quality. Demonstration of this laser provides a feasible scheme for the pulse energy scaling of mid-infrared MLFFLs. Moreover, a peculiar multi-soliton mode-locking state is also observed, in which the time interval between the solitons varies irregularly from tens of picoseconds to several nanoseconds.

Mid-infrared ultrashort pulses generated from a hybrid mode-locked Er:ZBLAN fiber laser.

By combining nonlinear polarization rotation (NPR) and semiconductor saturable absorber, we report a hybrid mode-locked Er:ZBLAN fiber oscillator at 2.8 µm. Stable 325-fs mode-locked pulses with an average power of 131 mW and a record signal-to-noise ratio of 79 dB at the fundamental frequency of 55.4 MHz are generated. Numerical simulations are carried out based on the modified coupled nonlinear Schrödinger equations, and offer new insights into the underlying dynamics of pulse generation. The simulations indicate that compared with Er:ZBLAN fiber lasers mode-locked by NPR alone, the hybrid mode-locked Er:ZBLAN fiber oscillator allows a wider range and a lower threshold of the pump power while maintaining the ultrashort pulse width. Moreover, we numerically demonstrate that the hybrid mode-locked oscillator is less sensitive to the variation of polarization states, which will increase its robustness against environmental disturbance. This is the first time that the hybrid mode-locking technique is applied in the mid-infrared, opening up new opportunities for the development of stable ultrafast mid-infrared laser sources and practical applications outside the laboratory.

Tunable mode-locked Tm-doped fiber laser based upon cross-phase modulation.

We demonstrate the generation of soliton and dissipative soliton in an ultrafast thulium (Tm) doped fiber laser based upon cross-phase modulation (XPM) induced mode-locking. The mode-locking is realized by periodically modulating the 2-µm signal through XPM that is activated by an injected 1.5-µm pulsed laser. Such a mechanism enables the laser to be mode-locked in various operation regimes without any real or artificial saturable absorbers. Thanks to the XPM pulling effect, the wavelength of the Tm-doped fiber laser can be tuned by adjusting the repetition frequency of the 1.5-µm pulsed laser. The maximum tuning ranges achieved in this work for the soliton and dissipative soliton regimes are respectively 11 nm and 15 nm. The outcomes of this work not only provide a continuously and controllably wavelength-tunable ultrafast laser but also offer a passively synchronized dual-color fiber laser system, which is promised for many important applications such as Raman spectroscopy, nonlinear frequency conversion systems, and multi-color pump-probe systems.

All-polarization-maintaining NALM mode-locked Er/Yb-doped large-mode-area fiber oscillator.

We report a mode-locked high-power all-polarization-maintaining Er/Yb-doped large-mode-area fiber oscillator based on a bias nonlinear amplifying loop mirror (NALM). The oscillator can generate ∼1-nJ femtosecond pulses without dispersion compensation. By inserting a Martinez-type compensator to provide normal dispersion, it can generate >10-nJ picosecond dissipative solitons (DSs). The measured M2 factors are below 1.5, indicating a good beam quality. When the cavity dispersion is tuned to be ∼0.704 ps2, the oscillator can deliver chirped DSs with an average power as high as 690 mW at a repetition rate of 49.86 MHz, corresponding to a pulse energy of ∼13.8 nJ. The pulse after compression has a near Fourier-limited width of ∼2 ps. Successful demonstration of this laser provides a robust scheme for improving the performance of ultrafast fiber lasers in average power and pulse energy.

Average-power (4.13 W) 59 fs mid-infrared pulses from a fluoride fiber laser system.

We report a high-average-power mid-infrared ultrafast laser system consisting of a fluoride fiber mode-locked oscillator and a nonlinear amplifier. A backward pumping scheme was used in the amplifier to simultaneously realize pulse amplification and self-compression. The input signal polarization was demonstrated to play an important role in the self-compression process. Through the optimization of input polarization, a 4.13 W average-power 59 fs pulse at 2.8 µm was achieved, with an estimated pulse energy of 42.2 nJ and a peak power of 715 kW. To the best of our knowledge, this is the highest average-power pulse with sub-100-fs duration generated from a mid-infrared fiber laser system to date.

High Modulation Depth Enabled by Mo2Ti2C3Tx MXene for Q-Switched Pulse Generation in a Mid-Infrared Fiber Laser.

Two-dimensional (2D) materials show great promise as saturable absorbers (SAs) for ultrafast fiber lasers. However, the relatively low modulation depth and poor stability of some 2D materials, such as graphene and black phosphorus, restrict their applications in the mid-infrared pulse generation. Herein, we first report a novel 2D double transition metal carbide, denoted as Mo2Ti2C3Tx MXene, as the saturable absorber (SA) for a passively Q-switched mid-infrared fiber laser. Due to the unique four-metal atomic layer structure, the Mo2Ti2C3Tx exhibits superior saturable absorption properties, particularly with a higher modulation depth (40% at 2796 nm) than most of the other reported 2D SA materials. After incorporating the MXene SA with an erbium-doped fiber system, the passively Q-switched pulses were achieved with a repetition rate of 157.3 kHz, the shortest pulse width of 370 ns, and single-pulse energy of 1.92 µJ, respectively. Such results extend the MXene-based SAs as promising candidates for advanced photonic devices.

Tunable thulium-doped mode-locked fiber laser with watt-level average power.

We demonstrate a wavelength-tunable, sub-200 fs, and watt-level thulium-doped ultrafast fiber oscillator with a fundamental frequency repetition rate of 509.7 MHz. The wavelength can be tuned between 1918.5 nm and 2031 nm by adjusting the intra-cavity waveplates. When the wavelength is tuned to below 2000 nm, the average output power exceeds 1 W. The oscillator provides a maximum average power of 1.314 W (corresponding to a pulse energy of 2.58 nJ) and a highest peak power of 12.5 kW at 1940 nm. Such a high-power, tunable 2-µm mode-locked fiber laser is an ideal light source candidate for a variety of applications, such as frequency metrology, molecular spectroscopy, and ultrafast pump-probe spectroscopy.

Generation of few-cycle pulses from a mode-locked Tm-doped fiber laser.

We report a compact, self-starting dispersion-managed mode-locked thulium-doped fiber oscillator that delivers 2.6 nJ pulses at 2 µm with a repetition rate of 250 MHz. The average output power and spectral bandwidth of the pulses reach impressive values of 648 mW and 103 nm, respectively. The generated pulses are near linearly chirped, capable of linearly compressing to 74 fs in a normal dispersion fiber after power attenuation. Using a nonlinear fiber compression scheme can even compress the pulses to 29 fs (4.3-cycle). The remaining pulse energy is 1.15 nJ, and the corresponding peak power is estimated as 39.4 kW. To the best of our knowledge, this is the first demonstration of nonlinearly compressing the pulse of a 2 µm fiber oscillator to the sub-5 cycle regime. Such a few-cycle fiber laser could be an ideal candidate source for short-wavelength mid-infrared frequency metrology and molecular spectroscopy applications.

Sub-200 fs, 344 MHz mode-locked Tm-doped fiber laser.

We demonstrate a compact, self-starting mode-locked thulium-doped fiber laser based on nonlinear polarization evolution (NPE), with a fundamental repetition rate of ∼344MHz and a pulse duration of ∼160fs. The generated pulses centered at ∼1975nm have a maximum output power of ∼560mW, corresponding to a pulse energy of ∼1.63nJ. To the best of our knowledge, the achieved repetition rate represents the highest value of fundamentally NPE mode-locked fiber lasers at ∼2µm, while the average output power is also higher than the previously reported 2 µm ultrafast single-mode fiber oscillators. The timing jitter in the integrated range [5 kHz, 10 MHz] and the integrated relative intensity noise in the range [10 Hz, 10 MHz] reach ∼35fs and ∼0.009%, respectively. Our high-performance laser is an ideal candidate for various applications, including mid-infrared frequency metrology and high-speed optical sampling.

High-power mode-locked thulium-doped fiber laser with tungsten ditelluride as saturable absorber.

A passively mode-locked thulium-doped fiber laser using a tungsten ditelluride saturable absorber (${{\rm WTe}_2}\mbox{-}{\rm SA}$WTe2-SA) is demonstrated. High-power mode-locked pulses with an average output power of 108.1 mW were achieved by incorporating the ${{\rm WTe}_2}\mbox{-}{\rm SA}$WTe2-SA into a thulium-doped fiber oscillator. To the best of our knowledge, this is the highest average power obtained from a ${{\rm WTe}_2}\mbox{-}{\rm SA}$WTe2-SA-based fiber laser. We further amplified the output power to 5.60 W with an all-fiber thulium-doped double-cladding fiber amplifier. Our result indicates that ${{\rm WTe}_2}\mbox{-}{\rm SA}$WTe2-SA could be an excellent candidate for a high-power fiber laser system.

Fundamental and harmonic mode-locked h-shaped pulse generation using a figure-of-9 thulium-doped fiber laser.

Herein, we present a fundamental and harmonic mode-locked figure-of-9 thulium-doped fiber laser using a nonlinear amplifying loop mirror. The generated fundamental mode-locked h-shaped pulse is centered at 1889 nm with an average output power reaching 282 mW and a pulse energy up to 1.23 µJ, which is the highest power and pulse energy of an h-shaped pulse. In the harmonic mode-locked regime, up to the 8th harmonic h-shaped pulse is obtained. The detailed characteristics of the h-shaped pulse are discussed. The proposed study shows that the figure-of-9 fiber laser can generate h-shaped pulses and also allows the generation of nanosecond pulses with a µJ-level pulse energy.

172 fs, 24.3 kW peak power pulse generation from a Ho-doped fiber laser system.

We demonstrate a high-peak-power femtosecond fiber laser system based on single-mode holmium (Ho)-doped fibers. 833 fs, 27.7 MHz pulses at 2083.4 nm generated in a passively mode-locked Ho fiber laser are amplified and compressed to near transform-limited 172 fs, 7.2 nJ pulses with 24.3 kW peak power. We achieve this performance level by using the soliton effect and high-order soliton compression. To the best of our knowledge, this is the first demonstration of sub-200 fs pulses, with peak power exceeding 10 kW from a Ho-doped single-mode fiber laser system without using bulk optics compressors.

α-In2Se3 wideband optical modulator for pulsed fiber lasers.

With the magnetron-sputtering deposition method, α phase indium selenide (α-In2Se3) was developed into a saturable absorber (SA) with wideband saturable absorption property at 800, 1560, and 1930 nm. After inserting the α-In2Se3 SA into erbium-doped fiber laser (EDFL) and thulium-doped fiber laser (TDFL) systems, we can easily obtain stable soliton pulse trains. The pulse duration/pulse energy/slope efficiency for EDFL and TDFL were 276 fs/2.03 nJ/15.8% and 1.02 ps/7.1 nJ/23.5%, respectively. These results showed that the MSD-grown α-In2Se3 could be regarded as high efficiency material to be applied in ultrafast photonics.

Raman scattering enhancement of a single ZnO nanorod decorated with Ag nanoparticles: synergies of defects and plasmons: publisher's note.

This publisher's note corrects an error in the funding section in Opt. Lett.43, 2244 (2018)OPLEDP0146-959210.1364/OL.43.002244.