Interpreting the retinal neural code for natural scenes: From computations to neurons.

Understanding the circuit mechanisms of the visual code for natural scenes is a central goal of sensory neuroscience. We show that a three-layer network model predicts retinal natural scene responses with an accuracy nearing experimental limits. The model's internal structure is interpretable, as interneurons recorded separately and not modeled directly are highly correlated with model interneurons. Models fitted only to natural scenes reproduce a diverse set of phenomena related to motion encoding, adaptation, and predictive coding, establishing their ethological relevance to natural visual computation. A new approach decomposes the computations of model ganglion cells into the contributions of model interneurons, allowing automatic generation of new hypotheses for how interneurons with different spatiotemporal responses are combined to generate retinal computations, including predictive phenomena currently lacking an explanation. Our results demonstrate a unified and general approach to study the circuit mechanisms of ethological retinal computations under natural visual scenes.

Predictive variational autoencoder for learning robust representations of time-series data.

Variational autoencoders (VAEs) have been used extensively to discover low-dimensional latent factors governing neural activity and animal behavior. However, without careful model selection, the uncovered latent factors may reflect noise in the data rather than true underlying features, rendering such representations unsuitable for scientific interpretation. Existing solutions to this problem involve introducing additional measured variables or data augmentations specific to a particular data type. We propose a VAE architecture that predicts the next point in time and show that it mitigates the learning of spurious features. In addition, we introduce a model selection metric based on smoothness over time in the latent space. We show that together these two constraints on VAEs to be smooth over time produce robust latent representations and faithfully recover latent factors on synthetic datasets.