Methodological and reporting quality of systematic reviews on health effects of air pollutants were higher than extreme temperatures: a comparative study.

BACKGROUND: An increasing number of systematic reviews (SRs) in the environmental field have been published in recent years as a result of the global concern about the health impacts of air pollution and temperature. However, no study has assessed and compared the methodological and reporting quality of SRs on the health effects of air pollutants and extreme temperatures. This study aims to assess and compare the methodological and reporting quality of SRs on the health effects of ambient air pollutants and extreme temperatures. METHODS: PubMed, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Library, Web of Science, and Epistemonikos databases were searched. Two researchers screened the literature and extracted information independently. The methodological quality of the SRs was assessed through A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2). The reporting quality was assessed through Preferred Reporting Items of Systematic reviews and Meta-Analyses (PRISMA). RESULTS: We identified 405 SRs (286 for air pollution, 108 for temperature, and 11 for the synergistic effects). The methodological and reporting quality of the included SRs were suboptimal, with major deficiencies in protocol registration. The methodological quality of SRs of air pollutants was better than that of temperature, especially in terms of satisfactory explanations for any heterogeneity (69.6% v. 45.4%). The reporting quality of SRs of air pollution was better than temperature, however, adherence to the reporting of the assessment results of risk of bias in all SRs (53.5% v. 34.3%) was inadequate. CONCLUSIONS: Methodological and reporting quality of SRs on the health effect of air pollutants were higher than those of temperatures. However, deficiencies in protocol registration and the assessment of risk of bias remain an issue for both pollutants and temperatures. In addition, developing a risk-of-bias assessment tool applicable to the temperature field may improve the quality of SRs.

Short-term joint effects of ambient PM2.5 and O3 on mortality in Beijing, China.

Introduction: In recent years, air pollution caused by co-occurring PM2.5 and O3, named combined air pollution (CAP), has been observed in Beijing, China, although the health effects of CAP on population mortality are unclear. Methods: We employed Poisson generalized additive models (GAMs) to evaluate the individual and joint effects of PM2.5 and O3 on mortality (nonaccidental, respiratory, and cardiovascular mortality) in Beijing, China, during the whole period (2014-2016) and the CAP period. Adverse health effects were assessed for percentage increases (%) in the three mortality categories with each 10-µg/m3 increase in PM2.5 and O3. The cumulative risk index (CRI) was adopted as a novel approach to quantify the joint effects. Results: The results suggested that both PM2.5 and O3 exhibited the greatest individual effects on the three mortality categories with cumulative lag day 01. Increases in the nonaccidental, cardiovascular, and respiratory mortality categories were 0.32%, 0.36%, and 0.43% for PM2.5 (lag day 01) and 0.22%, 0.37%, and 0.25% for O3 (lag day 01), respectively. There were remarkably synergistic interactions between PM2.5 and O3 on the three mortality categories. The study showed that the combined effects of PM2.5 and O3 on nonaccidental, cardiovascular, and respiratory mortality were 0.34%, 0.43%, and 0.46%, respectively, during the whole period and 0.58%, 0.79%, and 0.75%, respectively, during the CAP period. Our findings suggest that combined exposure to PM2.5 and O3, particularly during CAP periods, could further exacerbate their single-pollutant health risks. Conclusion: These findings provide essential scientific evidence for the possible creation and implementation of environmental protection strategies by policymakers.

Independent risk evaluation associated with short-term black carbon exposure on mortality in two megacities of Yangtze River Delta, China.

The adverse health effects of PM2.5 have been well demonstrated by many studies. However, as a component of PM2.5, evidence on the mortality risk of black carbon (BC) is still limited. In this study, based on the data of daily mean PM2.5 concentration, BC concentration, meteorological factors, total non-accidental (all-cause) and cardiovascular mortality in Shanghai and Nanjing during 2015-2016, a semi-parameter generalized additive model (GAM) in the time series and the constituent residual approach were employed to explore the exposure-response relationship between BC and human mortality in these two megacities of Yangtze River Delta, China. The main objective was to separate the health effects of BC from total PM2.5, and compare the difference of mortality ER related to BC original concentration and adjusted concentration after controlling PM2.5. Results showed that there were all significantly associated with daily mortality for PM2.5 and BC. The percentage excess risk (ER) increases in all-cause and cardiovascular categories were 1.68 % (95 % s 1.28, 2.08) and 2.16 % (95 % CI: 1.54, 2.79) with 1 µg/m3 increment in original BC concentration in Shanghai. And the ER in Nanjing was smaller than that in Shanghai. After eliminating PM2.5 confounding effects by a constituent residual approach, the BC residual concentration still had a strong significant ER. The ER for BC residual in Shanghai got an obvious increase, and ER of the cardiovascular mortality for all, females and males increased by 0.55 %, 1.46 % and 0.62 %, respectively, while the ER in Nanjing decreased slightly. It also revealed that females were more sensitive to the health risk associated with short-term BC exposure than males. Our findings provide additional important evidence and ER for mortality related to independent BC exposure. Therefore, BC emission reduction should be paid more attention in air pollution control strategies to reduce BC-related health burdens.

Stronger susceptibilities to air pollutants of influenza A than B were identified in subtropical Shenzhen, China.

Air pollution was indicated to be a key factor contributing to the aggressive spread of influenza viruses, whereas uncertainty still exists regarding to whether distinctions exist between influenza subtypes. Our study quantified the impact of five air pollutants on influenza subtype outbreaks in Shenzhen, China, a densely populated and highly urbanized megacity. Daily influenza outbreak data of laboratory-confirmed positive cases were obtained from the Shenzhen CDC, from May 1, 2013 to Dec 31, 2015. Concentrations of nitrogen dioxide (NO2), sulfur dioxide (SO2), particulate matters ≤2.5 µm (PM2.5), particulate matters ≤10 µm (PM10), and ozone (O3), were retrieved from the 18 national monitoring stations. The generalized additive model (GAM) and distributed lag non-linear model (DLNM) were used to calculate the concentration-response relationships between environmental inducers and outbreak epidemics, respectively for influenza A (Flu-A) and B (Flu-B). There were 1687 positive specimens were confirmed during the study period. The cold season was restricted from Nov. 4th to Apr. 20th, covering all seasons other than the long-lasting summer. Relatively heavy fine particle matter (PM2.5) and NO2 pollution was observed in cold months, with mean concentrations of 46.06 µg/m3 and 40.03 µg/m3, respectively. Time-series analysis indicated that high concentrations of NO2, PM2.5, PM10, and O3 were associated with more influenza outbreaks at short lag periods (0-5 d). Although more Flu-B (679 cases) epidemics occurred than Flu-A (382 cases) in the cold season, Flu-A generally showed higher susceptibility to air pollutants. A 10 µg/m3 increment in concentrations of PM2.5, PM10, and O3 at lag 04, was associated with a 2.103 (95%CI: 1.528-2.893), 1.618 (95%CI: 1.311-1.996), and 1.569 (95%CI: 1.214-2.028) of the relative risk (RR) of Flu-A, respectively. A 5 µg/m3 increase in NO2 was associated with higher risk of Flu-A at lag 03 (RR = 1.646, 95%CI: 1.295-2.092) and of Flu-B at lag 04 (RR = 1.319, 95%CI: 1.095-1.588). Nevertheless, barely significant effect of particulate matters (PM2.5, PM10) on Flu-B and SO2 on both subtypes was detected. Further, the effect estimates of NO2 increased for both subtypes when coexisting with other pollutants. This study provides evidence that declining concentrations of main pollutants including NO2, O3, and particulate matters, could substantially decrease influenza risk in subtropical Shenzhen, especially for influenza A.

Is short-term and long-term exposure to black carbon associated with cardiovascular and respiratory diseases? A systematic review and meta-analysis based on evidence reliability.

OBJECTIVE: Adverse health effects of fine particles (particulate matter2.5) have been well documented by a series of studies. However, evidences on the impacts of black carbon (BC) or elemental carbon (EC) on health are limited. The objectives were (1) to explored the effects of BC and EC on cardiovascular and respiratory morbidity and mortality, and (2) to verified the reliability of the meta-analysis by drawing p value plots. DESIGN: The systematic review and meta-analysis using adapted Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach and p value plots approach. DATA SOURCES: PubMed, Embase and Web of Science were searched from inception to 19 July 2021. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Time series, case cross-over and cohort studies that evaluated the associations between BC/EC on cardiovascular or respiratory morbidity or mortality were included. DATA EXTRACTION AND SYNTHESIS: Two reviewers independently selected studies, extracted data and assessed risk of bias. Outcomes were analysed via a random effects model and reported as relative risk (RR) with 95% CI. The certainty of evidences was assessed by adapted GRADE. The reliabilities of meta-analyses were analysed by p value plots. RESULTS: Seventy studies met our inclusion criteria. (1) Short-term exposure to BC/EC was associated with 1.6% (95% CI 0.4% to 2.8%) increase in cardiovascular diseases per 1 µg/m3 in the elderly; (2) Long-term exposure to BC/EC was associated with 6.8% (95% CI 0.4% to 13.5%) increase in cardiovascular diseases and (3) The p value plot indicated that the association between BC/EC and respiratory diseases was consistent with randomness. CONCLUSIONS: Both short-term and long-term exposures to BC/EC were related with cardiovascular diseases. However, the impact of BC/EC on respiratory diseases did not present consistent evidence and further investigations are required. PROSPERO REGISTRATION NUMBER: CRD42020186244.

Modification effects of ambient temperature on ozone-mortality relationships in Chengdu, China.

A multitude of epidemiological studies have demonstrated that both ambient temperatures and air pollution are closely related to health outcomes. However, whether temperature has modification effects on the association between ozone and health outcomes is still debated. In this study, three parallel time-series Poisson generalized additive models (GAMs) were used to examine the effects of modifying ambient temperatures on the association between ozone and mortality (including non-accidental, respiratory, and cardiovascular mortality) in Chengdu, China, from 2014 to 2016. The results confirmed that the ambient high temperatures strongly amplified the adverse effects of ozone on human mortality; specifically, the ozone effects were most pronounced at > 28 °C. Without temperature stratification conditions, a 10-µg/m3 increase in the maximum 8-h average ozone (O3-8hmax) level at lag01 was associated with increases of 0.40% (95% confidence interval [CI] 0.15%, 0.65%), 0.61% (95% CI 0.27%, 0.95%), and 0.69% (95% CI 0.34%, 1.04%) in non-accidental, respiratory, and cardiovascular mortality, respectively. On days during which the temperature exceeded 28 °C, a 10-µg/m3 increase in O3-8hmax led to increases of 2.22% (95% CI 1.21%, 3.23%), 2.67% (95% CI 0.57%, 4.76%), and 4.13% (95% CI 2.34%, 5.92%) in non-accidental, respiratory, and cardiovascular mortality, respectively. Our findings validated that high temperature could further aggravate the health risks of O3-8hmax; thus, mitigating ozone exposure will be brought into the limelight especially under the context of changing climate.

Novel Evidence Showing the Possible Effect of Environmental Variables on COVID-19 Spread.

Coronavirus disease (COVID-19) remains a serious issue, and the role played by meteorological indicators in the process of virus spread has been a topic of academic discussion. Previous studies reached different conclusions due to inconsistent methods, disparate meteorological indicators, and specific time periods or regions. This manuscript is based on seven daily meteorological indicators in the NCEP reanalysis data set and COVID-19 data repository of Johns Hopkins University from 22 January 2020 to 1 June 2021. Results showed that worldwide average temperature and precipitable water (PW) had the strongest correlation (ρ > 0.9, p < 0.001) with the confirmed COVID-19 cases per day from 22 January to 31 August 2020. From 22 January to 31 August 2020, positive correlations were observed between the temperature/PW and confirmed COVID-19 cases/deaths in the northern hemisphere, whereas negative correlations were recorded in the southern hemisphere. From 1 September to 31 December 2020, the opposite results were observed. Correlations were weak throughout the near full year, and weak negative correlations were detected worldwide (|ρ| < 0.4, p ≤ 0.05); the lag time had no obvious effect. As the latitude increased, the temperature and PW of the maximum confirmed COVID-19 cases/deaths per day generally showed a decreasing trend; the 2020-year fitting functions of the response latitude pattern were verified by the 2021 data. Meteorological indicators, although not a decisive factor, may influence the virus spread by affecting the virus survival rates and enthusiasm of human activities. The temperature or PW threshold suitable for the spread of COVID-19 may increase as the latitude decreases.

Drivers of 2013-2020 ozone trends in the Sichuan Basin, China: Impacts of meteorology and precursor emission changes.

The Sichuan Basin (SCB) of China is known for excessive ozone (O3) pollution owing to high anthropogenic emissions combined with terrain-induced poor ventilation and weak wind fields against the surrounding mountains. While O3 pollution has emerged as a prominent concern in southwestern China yet variations in O3 levels during 2013-2020 are still unclear and the dominant factor in explaining the long-term O3 trend throughout the SCB remains elusive due to uncertainties in emission inventory and variability associated with meteorological conditions. Here, we use extensive basin-wide ambient measurements to examine the spatial pattern and trend of O3 and leverage OMI and TROPOMI satellites in conjunction with MEIC emission inventory to track emission changes. Sensitivity simulations are conducted by using WRF-CMAQ model to investigate the impacts of meteorological variability and emission changes on O3 changes over 2013-2020. O3 concentrations exhibit obvious interannual increases during 2013-2019 and a slight decrease in 2020. Both decreases in the MEIC emission inventory (-2.9% yr-1) and OMI NO2 column density (-3.1% yr-1) reflects the declining trend in NOx emissions over 2013-2020, while anthropogenic VOCs were not adequately regulated during 2013-2017, which explained the majority of deteriorated O3 pollution from 2013 to 2017. Furthermore, attribution analysis based on CMAQ simulations indicate that the unexpected aggravated O3 levels in 2019 is not only modulated by disproportional reductions in VOCs and NOx emissions, but also associated with unfavorable meteorological conditions featured by profound heatwaves and frequent stagnant conditions. In 2020, the abnormal meteorological conditions in May leads to substantial increase of O3 by 26.8 µg m-3 as compared to May 2019, while the considerable enhancement was fully offset by low O3 levels over the whole period which attributes to substantial emission reductions. This study reveals the long-term trend of O3 levels and precursor emissions and highlights the effects of meteorological variability and emission changes on O3 pollution over the SCB, with strong implications for designing effective O3 control measures.

Influenza A and B outbreaks differed in their associations with climate conditions in Shenzhen, China.

Under the variant climate conditions in the transitional regions between tropics and subtropics, the impacts of climate factors on influenza subtypes have rarely been evaluated. With the available influenza A (Flu-A) and influenza B (Flu-B) outbreak data in Shenzhen, China, which is an excellent example of a transitional marine climate, the associations of multiple climate variables with these outbreaks were explored in this study. Daily laboratory-confirmed influenza virus and climate data were collected from 2009 to 2015. Potential impacts of daily mean/maximum/minimum temperatures (T/Tmax/Tmin), relative humidity (RH), wind velocity (V), and diurnal temperature range (DTR) were analyzed using the distributed lag nonlinear model (DLNM) and generalized additive model (GAM). Under its local climate partitions, Flu-A mainly prevailed in summer months (May to June), and a second peak appeared in early winter (December to January). Flu-B outbreaks usually occurred in transitional seasons, especially in autumn. Although low temperature caused an instant increase in both Flu-A and Flu-B risks, its effect could persist for up to 10 days for Flu-B and peak at 17 C (relative risk (RR) = 14.16, 95% CI: 7.46-26.88). For both subtypes, moderate-high temperature (28 C) had a significant but delayed effect on influenza, especially for Flu-A (RR = 26.20, 95% CI: 13.22-51.20). The Flu-A virus was sensitive to RH higher than 76%, while higher Flu-B risks were observed at both low (< 65%) and high (> 83%) humidity. Flu-A was active for a short term after exposure to large DTR (e.g., DTR = 10 C, RR = 12.45, 95% CI: 6.50-23.87), whereas Flu-B mainly circulated under stable temperatures. Although the overall wind speed in Shenzhen was low, moderate wind (2-3 m/s) was found to favor the outbreaks of both subtypes. This study revealed the thresholds of various climatic variables promoting influenza outbreaks, as well as the distinctions between the flu subtypes. These data can be helpful in predicting seasonal influenza outbreaks and minimizing the impacts, based on integrated forecast systems coupled with short-term climate models.

[Effects of Interaction between PM2.5 and O 3 8-h max on Mortality of Cardiovascular Diseases in Chengdu].

OBJECTIVE: To explore the health risks of the interactive effects between PM2.5 and ozone on cardiovascular mortality in Chengdu. METHODS: Daily data on the mortality of cardiovascular diseases, including data for both men and women, during 2014-2016 were collected. The meteorological data, the daily average of particulate matter with aerodynamic diameter less than 2.5 micrometers (PM2.5), and the daily ozone 8 h maximum concentration (O 3 8-h max) in Chengdu of the same period were also collected. Generalized Additive Models (GAMs) were adopted to explore the respective adverse health effects of PM2.5 and O 3 8-h max and the synergistic effects between PM2.5 and O 3 8-h max on the mortality of cardiovascular diseases in the city. RESULTS: The highest health risks of PM2.5 and O 3 8-h max for mortality of cardiovascular diseases were found to be the strongest for the cumulative effect of the lag of one day (lag01). For every 10 µg/m 3 increment in the mass concentration of PM2.5 (lag01), the associated increase in risks for total, male, and female cardiovascular mortalities was 0.35%, 0.26% and 0.38%, respectively. For every 10 µg/m 3 increment in the mass concentration of O 3 8-h max (lag01), the associated increase in risks for total, male, and female cardiovascular mortalities was 0.66%, 0.43%, and 1.05%, respectively. The total, male, and female cardiovascular mortalities all reached their maximum values when high concentration of PM2.5 coexisted with high concentrations of O 3 8-h max. CONCLUSION: There was a synergistic amplification effect between high concentrations of PM2.5 and high concentrations of O 3 8-h max on cardiovascular mortality.

[Interactive Effects of the Influencing Factors on the Changes of O3 Concentrations Based on GAMs Model in Chengdu].

To explore the influence characteristics of the interaction effects between meteorological factors on ozone(O3) concentration in Chengdu, daily air pollutants and meteorological data from 2014 to 2019 were collected. Generalized additive models(GAMs) were adopted to explore the effects of different factors on O3 concentration. The results showed that the relationship between O3 and maximum temperature, sunshine hours, relative humidity, wind speed, precipitation, maximum mixed depth(MMD), and ventilation coefficient(VC) was non-linear. Specifically, the maximum temperature, sunshine hours, MMD, and relative humidity had a significant influence on O3 concentration throughout the year. It is worth noting that the influence of relative humidity and precipitation on O3 concentration during summer was more significant than that for the whole year. In the multi-meteorological factors GAMs of O3 concentration, the meteorological factors mentioned above, except average wind, had significant impacts on O3 concentration change. For the whole year, the judgment coefficient(R2) was 0.849 and the variance explanation rate was 85.1%. The maximum temperature was the most important influencing factor on O3 concentration throughout the year. During summer, corresponding R2 was 0.811 and the explanation rate of variance was 81.3%; however, maximum temperature and MMD were the dominant meteorological factors. In the interaction GAMs, for the whole year, the interaction between maximum temperature and sunshine hours, relative humidity, and precipitation, and the interaction between sunshine hours and MMD had a significant impact on O3 concentrations. The interaction between maximum temperature and sunshine hours played a leading role in changes of O3 concentration. The high temperature+strong radiation+MMD(about 2000 m) +no precipitation were conducive to the formation of O3 concentration, but in summer, only the maximum temperature, sunshine hours, and VC had the most significant effect on the O3 concentration, and strong high temperatures+strong radiation+the little horizontal wind in summer were conducive to the formation of O3 concentration near the surface. In summary, GAMs model can not only be used to identify the dominant influencing factors of O3 pollution, but also quantitatively analyze the influence of single effects and interaction of influencing factors on O3 concentration, which has great significance for the prevention and control of O3 pollution.

Effect of diurnal temperature change on cardiovascular risks differed under opposite temperature trends.

Temperature change between neighboring days (TCN) is an important trigger for cardiovascular diseases, but the modulated effects by seasonal temperature trends have been barely taken into account. A quantified comparison between impacts of positive TCNs (temperature rise) and negative situations (temperature drop) is also needed. We evaluated the associations of TCNs with emergency room (ER) visits for coronary heart disease (CHD) and cerebral infarction (CI) in Beijing, China, from 2008 to 2012. A year was divided into two segments dominated by opposite temperature trends, quasi-Poisson regression with distributed lag nonlinear models estimating TCN-morbidity relations were employed, separately for each period. High morbidities of CHD and CI both occurred in transitional seasons accompanied by large TCNs. Under warming backgrounds, positive TCNs increased CHD risk in patients younger than 65 years, and old people showed limited sensitivity. In the cooling periods, negative TCNs induced CHD risk in females and the elderly; the highest RR showed on lag 6 d. In particular, a same diurnal temperature decrease (e.g., - 2°C) induced greater RR (RR = 1.113, 95% CIs: 1.033-1.198) on old people during warming periods than cooling counterparts (RR = 1.055, 95% CIs: 1.011-1.100). Moreover, positive TCNs elevated CI risk regardless of background temperatures, and males were particularly vulnerable. Seasonal temperature trends modify TCN-cardiovascular morbidity associations significantly, which may provide new insights into the health impact of unstable weathers.

Origin of regional springtime ozone episodes in the Sichuan Basin, China: Role of synoptic forcing and regional transport.

The Sichuan Basin (SCB) located in southwestern China has long been considered the most polluted city cluster with exposure to unhealthy levels of ozone (O3) at times. However, the features of O3 regional transport and source contributions in SCB are poorly understood. In this study, ambient measurements, ERA5 reanalysis dataset, IASI O3 column, and the Weather Research and Forecasting-Community Multiscale Air Quality (WRF-CMAQ) modeling system coupled with the Integrated Source Apportionment Method (ISAM) module were used to investigate the formation mechanism and sources of a severe O3 episode in spring 2020 over the SCB. In the first stage of the O3 episode, a high-pressure system persisted over the western SCB and caused northeasterly wind fields, leading to enhanced regional transport from the northern boundary with the O3 contribution from the boundary exceeding 50% across the SCB. As the synoptic pattern evolved, southeasterly winds dominated the SCB and the stagnant zone over the Chengdu Plain confined O3 originating from the southern SCB and Chongqing city, leading to the accumulation of precursors and elevated O3 levels. During the O3 episode, transportation and industrial sources were major contributors to O3 formation especially for the Chengdu Plain and Chongqing city. In addition, the O3-rich air mass in the nocturnal residual layer that formed over Chongqing city was transported to the Chengdu Plain through southeastern corridor at 400-1600m above ground-level under the prevailing southeasterly winds. With sunrise and the development of the atmospheric boundary layer, the O3-rich air mass in the residual layer (RL) was entrained to the ground-level via vertical mixing, which further enhanced O3 pollution across the Chengdu Plain. Our results revealed the mechanism of regional transport via northeastern and southeastern corridors during an O3 episode and demonstrated the need for joint emission regulation across the SCB to mitigate O3 pollution.

Influence of air pollution on human comfort in five typical Chinese cities.

It is known that air pollution is harmful to creatures, though until now most of the human thermal comfort indices that existed were calculated only with meteorological conditions. Therefore, a new index - meteorology and environment comfort (MEC) - was given out in this paper that considers both meteorology and air pollution conditions and presents the comprehensive and synergistic effects of meteorological and air pollution. The meteorology and air pollution data were used to establish the influence function of the five air pollutants (PM2.5, PM10, O3, NO2, and SO2) according to Fechner's law; then, we calculated the somatosensory temperature (ST, a class of human thermal comfort indices) and MEC values of five typical cities (Beijing, Xining, Nanjing, Kunming, and Guangzhou). The results showed average improvements of five cities on MEC as a new comprehensive human comfort index to new ST. In spring, the MEC comfort proportion fell by 29.25%. Besides, the extreme heat discomfort ratio in Nanjing and Kunming has increased over 20%. In summer, the comfort proportion fell 12.54%; the extreme heat discomfort proportion of Beijing increased 37.86% and Kunming increased 24.09%. Air pollution significantly raised discomfort stress in Beijing. In fall, the comfort proportion fell by 20.87%; and the extreme heat discomfort of Nanjing increased 23.67% caused by poor air quality. About winter, the comfort ratio decreased 12.72%, and the cold discomfort proportion of Nanjing increased 30.30%, signifying awful air quality in winter. Air pollution levels significantly affect the comfort levels in all seasons, which is more evident with good weather patterns. MEC can offer early warnings of extreme weather events and provide a basis for the better prevention and control of air pollution to protect human health basing on the predictions of meteorological and environmental impact factors.

Associations between winter atmospheric teleconnections in drought and haze pollution over Southwest China.

In the early 21st century, Southwest China (SWC) frequently experienced extreme droughts and severe haze pollution events. Although the meteorological causes of these extreme droughts have been widely investigated, previous studies have yet to understand the causes of haze pollution events over SWC. Moreover, the associations between winter atmospheric teleconnections during drought and haze pollution event across SWC has received negligible attention and therefore warrants investigation. This study examines the associations between the atmospheric teleconnections with respect to winter droughts and winter haze pollution over SWC. Our main conclusions are as follows. (1) Winter precipitation and winter haze days (WHD) over SWC had three major fluctuations from 1959 to 2016. (2) The atmospheric circulation pattern over the Eurasian (EU) continent associated with WHD over SWC resembled that of winter droughts over SWC, where both can be characterized by an EU teleconnection pattern. The Arctic Oscillation (AO) mainly induced the atmospheric circulation pattern over the EU continent that is associated with WHD over SWC. (3) The sea surface temperature (SST) and low circulation anomalies in the Pacific and north Atlantic associated with WHD were similar to those associated with winter droughts over SWC. La Niña events and negative phases of the North Atlantic Oscillation (NAO) may induce winter drought and increase the WHD over SWC. (4) Compared with winter drought over SWC, the variation in the WHD was more complex and the factors affecting WHD were more diverse, and winter drought and its related atmospheric circulations were important factors that induced haze pollution over SWC. Overall, this study not only fills a gap in the literature with respect to the associations between the atmospheric teleconnections of winter drought and winter haze pollution over SWC, but also provides an important scientific basis for the development of potential predictions of local monthly haze pollution, which improves the forecast accuracy of local short-term haze pollution and enriches the theoretical understanding of the meteorological causes of local haze pollution.

The impact of main air pollutants on respiratory emergency department visits and the modification effects of temperature in Beijing, China.

Research indicates that air pollution is a risk factor of an increased occurrence of diseases. However, evidence is limited on the effects of the pollution index on disease and whether temperature modifies the effects. The objectives were (i) to explore the effects of the Air Pollution Index (API) and specific indices for pollutants (PM10, NO2, and SO2) on respiratory emergency department (ED) visits in Beijing and (ii) to investigate whether temperature modified the effects of main air pollutants on respiratory ED visits. A quasi-Poisson generalized additive model was employed to examine the association of API and indices for pollutants with respiratory disease. Bivariate response surface model and stratification model (cold days, moderately cold days, moderately hot days, and hot days) were used to analyze the modification effects of temperature on air pollution and respiratory disease. The results showed that (i) the effects of API on respiratory diseases were similar to the index for PM10 in Beijing. (ii) API and PM10 were associated with increased respiratory ED visits on cold days and moderately cold days. Furthermore, the effects of PM10 on respiratory disease on moderately cold days [Relative risk (RR) = 1.006 per 10 µg/m3, 95% CI 1.002-1.009] were stronger than on cold days (RR = 1.004 per 10 µg/m3, 95% CI 1.000-1.008). (iii) PM10 (API) had a greater impact on children aged 10 to 17 years and females on moderately cold days, while the elderly had an increased risk of respiratory disease to PM10 (RR = 1.008 per 10 µg/m3, 95% CI 1.002-1.013) and API (RR = 1.013 per 10, 95% CI 1.004-1.022) on cold days. In conclusion, temperature can modify the association between API and respiratory morbidity. A stronger correlation existed between PM10 and respiratory diseases on moderately cold days, while the effects of cold days were less than that attributable to moderately cold days.

Meteorological rhythms of respiratory and circulatory diseases revealed by Harmonic Analysis.

The intricately fluctuating onset of respiratory and circulatory diseases displays rhythms of multi-scaled meteorological conditions due to their sensitivity to weather changes. The intrinsic meteorological rhythms of these diseases are revealed in this bio-meteorological study via Fourier decomposition and harmonic analysis. Daily emergency room (ER) visit data for respiratory and circulatory diseases from three comprehensive hospitals in Haidian district of Beijing, China were used in the analysis. Meteorological data included three temperature metrics, relative humidity, sunshine duration, daily mean air pressure, and wind speed. The Fourier decomposition and harmonic analysis on ER visits and meteorological variables involve frequency, period, and power of all harmonics. The results indicated that: i) for respiratory morbidity, a strong climatic annual rhythm responding to annual temperature change was firstly revealed; its ratio of spectral density was 16-33%. Moreover, significant correlations existed between the high-frequency fluctuations (<30 d) of morbidity and short-term harmonics of humidity and solar duration. High-frequency harmonics of temperature and pressure showed no statistically significant effect. ii) With regard to all types of circulatory morbidity, their annual periodicity was weaker than that of respiratory diseases, whose harmonic energy took a ratio less than 8%. Besides, the power of all high-frequency harmonics of circulatory morbidity accounted for up to 70-90% in the original sequences, and their relationship to many short-term meteorological factors were significant, including the mean and maximum temperatures, wind speed, and solar duration. iii) The weekly rhythm appeared in respiratory ER visits with 15% of harmonic variance but not prominent in circulatory morbidity. In summary, by decomposing the sequence of respiratory and circulatory diseases as well as recognizing their meteorological rhythms, different responses to meteorological conditions on various time scales were identified.

Chimeric Peptides Self-Assembling on Titanium Carbide MXenes as Biosensing Interfaces for Activity Assay of Post-translational Modification Enzymes.

Post-translational modifications (PTMs) refer to the chemical modifications of proteins coordinated by PTM enzymes, and they play a key role in numerous physiological and pathological processes. Herein, chimeric peptide-functionalized titanium carbide MXenes (Pep-Ti3C2) were devised for the activity assay of PTM enzymes by integration with carboxypeptidase Y (CPY)-mediated peptide cleavage. The Pep-Ti3C2 is fabricated by self-assembly of chimeric peptide probes on the surface of phospholipid-coated Ti3C2 MXenes and works as the fluorescent nanoprobe for the sensing of PTM enzymes. In the presence of a target PTM enzyme, the modification groups in the peptide probes are removed along with the digestion of the peptides by CPY, thereby leading to the release of labeled fluorophores. Consequently, fluorescent analysis of PTM enzymes, including deacetylase sirtuin-1 and protein phosphatase 2C at low-nanomolar concentrations was achieved. Furthermore, the versatility of the nanoprobes was also demonstrated in simultaneous profiling of the activities of the two PTM enzymes in different cells, as well as in evaluation of the inhibition on PTMs by small molecules in complicated biological samples. Therefore, this work deploys peptide-functionalized MXenes as a generic biosensing interface for the activity assay of PTM enzymes, providing a useful tool for biochemical research and clinical diagnosis.

Association between moderately cold temperature and mortality in China.

Ambient air temperature is a key factor affecting human health. Adverse effects of extreme weather on mortality have been well explored and expounded in numerous epidemiological studies. The relationship between moderate temperature and mortality is, however, underexplored. This study quantitatively investigated the temperature-dependent mortality burden in China. Data on daily average temperature and mortality in 15 Chinese cities during 2010-2016 were collected for this study. The association between temperature and city-specific mortality was investigated with a quasi-Poisson regression combined with a distributed lag nonlinear model across lag 0-21 days. The results were then included in a multivariate meta-analysis to derive the pooled estimates of the effect of temperature on mortality at the multi-city level. Mortality fractions attributable to cold and heat (i.e., at temperatures below and above the minimum mortality temperature (MMT)) were calculated. Additionally, temperature ranges were further divided into 1 °C intervals of ambient temperature, and the attributable fractions were calculated for each range. The MMT varied from the 71th to 93th percentiles of temperature in the 15 Chinese cities, centering at the 78th percentile at the multi-city level. In total, 12.65% of non-accidental mortality was attributable to non-optimum temperature, of which cold and hot temperatures corresponded to attributable fractions of 11.38% and 1.27%, respectively. The results of temperature stratifications suggested that moderately cold temperatures provided the highest contribution to mortality caused by temperature. Specifically, the highest attributable fractions were at 7 °C, 7 °C, 8 °C, 8 °C, 4 °C, 4 °C, 5 °C, 7 °C, 7 °C, 4 °C, 5 °C, 5 °C, 6 °C, 11 °C, and 12 °C, for Harbin, Changchun, Shenyang, Urumqi, Beijing, Tianjin, Shijiazhuang, Xining, Lanzhou, Nanjing, Shanghai, Hefei, Chengdu, Kunming, and Guangzhou, respectively. Cold temperature was responsible for a higher proportion of deaths than heat. Moderate cold temperature contributed to most of the total health burden. Finally, the cumulative total counts of deaths caused by moderate cold were the largest. Although moderate cold conferred a slightly lower relative risk than extreme cold, it was more common than extreme cold. Taken together, our results show that the effects of moderate cold temperature on health should receive more attention. Furthermore, our findings could help improve the prediction of climate change effects on human health and support the development of response strategies for the changing climate.

Temperature inversions in the atmospheric boundary layer and lower troposphere over the Sichuan Basin, China: Climatology and impacts on air pollution.

The Sichuan Basin (SB) is one of the four most severely polluted regions in China in terms of air quality, and the frequent generation of temperature inversions is a key factor. The deep mountain-basin topography and the geographical location adjacent to the Tibetan Plateau combine to make the inversion characteristics of this region unique. Knowledge regarding these characteristics remains limited, however. In this study, the radiosonde data at standard pressure levels and significant levels from all SB operational radiosonde stations over 2015-2018 were used to document the climatological features of the inversions from the surface to a height of 5500 m and to evaluate the impact on local air pollutant concentrations. Results revealed that the temperature inversion in the SB is a common and year-round phenomenon. The annual inversion frequency, depth, and strength values are 74.4%, 252.2 m, and 1.3 °C/100 m, respectively. The inversions are most frequent (95.4%), deepest (289.4 m), and strongest (1.6 °C/100 m) in winter. They tend to occur at one of two heights, either below 600 m or between 2200 and 3500 m. Based on their bottom heights, the inversions were divided into three groups: surface-based inversions (SIs), elevated inversions (EIs), and lower-troposphere inversions (LTIs). Annual LTI is most frequent (63.0%) and deepest (264.7 m), while annual SI is strongest (1.8 °C/100 m). Extreme contrasts exist in the seasonal properties of different inversion types. All types of inversions play a considerable role in air pollution, resulting in a high probability of severe and very serious pollution in winter. SI has a greater impact on pollutant concentrations than EI and LTI. The frequent generation of LTIs is a unique feature of the deep SB. LITs exert a significant impact on the formation of local heavy air pollution, but have not been given sufficient attention.