A Free-Space Optical Communication System Based on Bipolar Complementary Pulse Width Modulation.

In this work, we propose a bipolar complementary pulse width modulation strategy based on the differential signaling system, and the modulation-demodulation methods are introduced in detail. The proposed modulation-demodulation strategy can effectively identify each symbol's start and end time so that the transmitter and receiver can maintain correct bit synchronization. The system with differential signaling has the advantages of not requiring channel state information and reducing background radiation. To further reduce the noise in the system, a multi-bandpass spectrum noise reduction method is proposed according to the spectrum characteristics of the received modulation signals. The proposed modulation method has an error bit rate of 10-5 at a signal-to-noise ratio of 7 dB. The fabricated optical communication system can stably transfer voice and text over a distance of 5.6 km.

miR-218-5p in endometrial microenvironment prevents the migration of ectopic endometrial stromal cells by inhibiting LASP1.

BACKGROUND: Our previous two-dimensional electrophoresis experiment showed that the expression of LASP1 in patients with endometriosis was significantly higher than that of control endometrium. However, the molecular mechanism by which LASP1 is regulated in endometriosis/adenomyosis is unknown. METHODS: Herein, qPCR was performed to analyze the expression levels of LASP1 and miR-218-5p between endometriosis (Ems) cells and control cells. Fluorescence in situ hybridization was carried out to measure the expression level of miR-218-5p in ectopic endometrium versus normal endometrium. After miR-218-5p mimic or inhibitor were transfected, the transwell experiment was carried out to see the effect of miR-218-5p on the migration of endometrial stromal cells (ESCs). EdU was used to measure cell proliferation rate. Dual-luciferase reporter assay was used to verify the binding of hsa-miR-218-5p to the 3'UTR of LASP1. Western blot and immunofluorescence analysis were carried out to identify the protein expression pattern of LASP1 and EMT markers in endometrial tissue. RESULTS: The miR-218-5p is mainly secreted from blood vessels and expressed in the muscle layer around the endometrium, which inhibits the expression level of LASP1 by binding the 3'UTR region of LASP1 in normal ESCs. Overexpression of miR-218-5p impedes the epithelial-to-mesenchymal transition (EMT) and prevents the migration of ESCs and the expression of Vimentin in Ems. CONCLUSIONS: Our findings revealed that miR-218-5p in endometrial microenvironment prevents the migration of ectopic endometrial stromal cells by inhibiting LASP1.

Time-multiplexed stereoscopic display with a quantum dot-polymer scanning backlight.

We fabricate a time-multiplexed stereoscopic display, which is composed of a quantum dot-polymer (QDP) scanning backlight, 120 Hz liquid crystal display (LCD), and shutter glasses. Blue LEDs, which can excite QDP film to produce white light, are adopted to replace the traditional white LEDs. The QDP scanning backlight, LCD, and shutter glasses can be controlled by the synchronization signal and work together, enabling viewers to obtain parallax views. Crosstalk is about 1%, and luminance through the shutter glasses is higher than 150 nit. The color gamut can be widely extended to 77.98% rather than the traditional 55.75% in the ITU-R Recommendation BT.2020 (Rec.2020) color space, due to the excellent properties of QD material.

Accuracy evaluation of digital surgical template in angled implantation in the maxillary posterior region / 口腔疾病防治

Objective@#To evaluate the accuracy of digital surgical guide in tilted implant in the maxillary posterior region.@*Methods @# Jaw data from 14 patients were scanned using cone beam computed tomography (CBCT), and digital models were acquired by scanning maxillary plaster models. Implant software was employed to process jaw data and digital models in order to design the surgical template. Then the stereolithographic (SLA) surgical template was created to guide the surgery. After that CBCT data was collected again and compared with the data collected before. Deviations between the actual implant position and the planned implant position were analyzed. @*Results@#Central deviation at the hex and apex between the actual implant and the planned implant was almost constant with a mean of (0.625 ± 0.183) mm and (0.820 ± 0.208) mm. Mean value of horizontal deviation at the hex was (0.314 ± 0.070) mm, horizontal deviation at the apex was (0.509 ± 0.139) mm, vertical deviation at the hex was (0.538 ± 0.178) mm, vertical deviation at the apex was (0.638 ± 0.178) mm. @*Conclusion@#Angled implantation in the maxillary posterior region can reduce risks and trauma as well as the difficulties and duration of surgery. However, our data suggested that significant deviations existed in the actual implant position and the planned implant position.

A comparative study between the immediate and early implant on the aesthetic influences of the peri-implant soft tissues in the aesthetic area / 口腔疾病防治

Objective@# The aim was to compare and document the aesthetic influences on peri-implant soft tissues between the immediate and early implant placement in the aesthetic area. @*Methods @#22 patients with single anterior teeth missing were included and divided into 2 group. Group A (12cases): Following the extraction of teeth, 12 Zimmer implants were immediately placed into sockets. Group B (10 cases): 4~8 weeks after the extraction, 10 Zimmer implants were early placed into the healing sockets. Zirconia crowns were applied on the implants 6 months later after implantation. The peri-implant soft tissues in both group were examined and evaluated by pink esthetic score (PES) 6~12 months later. Analysis of the data was performed by software SPSS 13.0. @*Results @#The mean PES was 9.27 (clinical acceptance) for all of the implants. No significant were found for any of the parameters between the treatment modalities regardness of total PES or single PES. However there were significant differences in the following aspects: the correlation between periodontal disease and papilla, the correlation between gingival biotype and mesial papilla, the correlation between gingival biotype and alveolar process deficiency, the correlation between Implant location and midfacial soft tissue level. @*Conclusion@#There are no significant differences between immediate placement and early placement on the aesthetic outcome of peri-implant soft tissues. The aesthetic outcome are related to patients oral health condition and clinicians skills.

Effects of Er-Zhi-Wan on microarchitecture and regulation of Wnt/ß-catenin signaling pathway in alveolar bone of ovariectomized rats.

Recent studies have shown that Er-Zhi-Wan (EZW), a traditional Chinese medicine consisting of Herba Ecliptae (HE) and Fructus Ligustri Lucidi (FLL), had a definite antiosteoporotic effect on osteoporotic femur, but its effect on osteoporosis of alveolar bone remains unknown. In the present study, we investigated the effects of Er-Zhi-Wan (EZW) on the microarchitecture and the regulation of Wnt/ß-catenin signaling pathway in the alveolar bone of ovariectomized rats. Thirty Sprague-Dawley rats were randomly divided into three groups: sham operation group (sham, n=10), ovariectomy (OVX) group (n=10), and OVX with EZW treatment group (EZW group, n=10). From one week after ovariectomy, EZW (100 mg/mL) or vehicle (distilled water) was fed (1 mL/100 g) once per day for 12 weeks until the sacrifice of the rats. The body weights were measured weekly. After sacrifice, the sera and mandible were collected and routinely prepared for the measurement of alveolar trabecular microarchitecture, serum levels of E2, bone-specific alkaline phosphatase (BALP) and tartrate-resistant acid phosphatase 5b (TRAP5b), as well as mandibular mRNA expression of Wnt/ß-catenin signaling pathway molecules wnt3a, low-density lipoprotein receptor-related protein 5 (LRP5), ß-catenin and dickkopf homolog 1 (DKK1). The results showed that EZW treatment significantly prevented the body weight gain, degradation of alveolar trabecular microarchitecture and alveolar bone loss in the OVX rats. Furthermore, we observed that EZW could increase the serum levels of E2 and BALP, and decrease levels of serum TRAP5b in EZW group compared with vehicle group. In addition, RT-PCR results revealed that EZW upregulated the expression levels of wnt3a, LRP5 and ß-catenin, and reduced the expression of DKK1 in OVX rats. Taken together, our results suggested that EZW may have potential anti-osteoporotic effects on osteoporotic alveolar bone by stimulating Wnt/LRP5/ß-catenin signaling pathway.

The osteogenic potential of mesoporous bioglasses/silk and non-mesoporous bioglasses/silk scaffolds in ovariectomized rats: in vitro and in vivo evaluation.

Silk-based scaffolds have been introduced to bone tissue regeneration for years, however, their local therapeutic efficiency in bone metabolic disease condition has been seldom reported. According to our previous report, mesoporous bioactive glass (MBG)/silk scaffolds exhibits superior in vitro bioactivity and in vivo osteogenic properties compared to non-mesoporous bioactive glass (BG)/silk scaffolds, but no information could be found about their efficiency in osteoporotic (OVX) environment. This study investigated a biomaterial-based approach for improving MSCs behavior in vitro, and accelerating OVX defect healing by using 3D BG/silk and MBG/silk scaffolds, and pure silk scaffolds as control. The results of SEM, CCK-8 assay and quantitative ALP activity showed that MBG/silk scaffolds can improve attachment, proliferation and osteogenic differentiation of both O-MSCs and sham control. In vivo therapeutic efficiency was evaluated by µCT analysis, hematoxylin and eosin staining, safranin O staining and tartrate-resistant acid phosphatase, indicating accelerated bone formation with compatible scaffold degradation and reduced osteoclastic response of defect healing in OVX rats after 2 and 4 weeks treatment, with a rank order of MBG/silk > BG/silk > silk group. Immunohistochemical markers of COL I, OPN, BSP and OCN also revealed that MBG/silk scaffolds can better induce accelerated collagen and non-collagen matrix production. The findings of this study suggest that MBG/silk scaffolds provide a better environment for cell attachment, proliferation and differentiation, and act as potential substitute for treating local osteoporotic defects.