Psychiatric implications of anti-seizure medications in epileptic population.

BACKGROUND AND OBJECTIVE: Epilepsy is a prevalent neurological disorder that affects a significant number of individuals globally. This condition is associated with a high occurrence of psychiatric comorbidities, which can significantly affect the quality of life of individuals affected. The aim of this study was to investigate the association between antiseizure therapies and the likelihood of psychiatric comorbidities in individuals with epilepsy. METHODOLOGY: Data for this study was gathered from the Neurology referral center in Islamabad, Pakistan. A standardized questionnaire was utilized to gather data from 120 individuals diagnosed with epilepsy. The survey consisted of inquiries regarding the management of seizures, the utilization of anti-seizure medications, and the presence of psychiatric comorbidities. The data was analyzed using the Statistical Package for the Social Sciences (SPSS). RESULTS: The findings indicated that individuals who were using multiple antiseizure medications had a notably higher likelihood of having psychiatric comorbidities in comparison to those who were on mono therapy (p = 0.010). suggests that patients with unsuccessful seizure control are more probable to have psychiatric comorbidities as compared to those with good seizure control (p = 0.029). CONCLUSION: To conclude poor seizure control and poly therapy are associated with increased risk of psychiatric comorbidities.

Neurological Manifestations in Two Cases of En Coup De Sabre.

Scleroderma En Coup de Sabre (ECDS) is a form of localised scleroderma that primarily develops in the younger population, usually before the age of 18 years and occurs on the scalp or forehead. In localised scleroderma, en coup de sabre, many studies and case reports describe neurological signs and symptoms. Two patients with the disease are reported here who were noted to have brain cysts by neuroimaging. It is important to specifically inquire about neurological symptoms and signs in the history and examination, respectively, and to consider neuroimaging in patients with scleroderma en coup de sabre to diagnose and treat neurological complications. Key Words: Localised  scleroderma, en Coup de Sabre, Neurological manifestations.