1.
Bioorg Med Chem Lett
; 13(10): 1657-60, 2003 May 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12729635
RESUMO
Using the pyrrolidine-5,5-trans-lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 2b, with a spiro-cyclobutyl P1 substituent and an isopropyl carbonyl substituent at the lactam nitrogen, has an IC(50) value in the replicon cell-based assay of 3 microM.