RESUMO
Six cases of smooth muscle tumors of the stomach are reported. These comprise one leiomyosarcoma and five leiomyomas, observed over a period of five years. Clinical presentation, diagnosis difficulties and the method of treatment are discussed and the literature is reviewed.
Assuntos
Leiomioma/diagnóstico , Leiomiossarcoma/diagnóstico , Neoplasias Gástricas/diagnóstico , Adulto , Anemia/complicações , Feminino , Gastrectomia , Hemorragia Gastrointestinal/diagnóstico , Gastroscopia , Humanos , Leiomioma/terapia , Leiomiossarcoma/terapia , Masculino , Pessoa de Meia-Idade , Músculo Liso , Estômago , Neoplasias Gástricas/terapiaAssuntos
Asbestose/diagnóstico , Pneumoconiose/diagnóstico , Escarro/citologia , Citodiagnóstico , Egito , Humanos , MasculinoRESUMO
PIP: An investigation was carried out on albino rats in order to study the effects of estradiol, progesterone, and some of the different synthetically prepared steroid combinations on the adrenocortical activity. Biochemical determination of adrenocortical alkaline phosphatase activity was carried out in normal female rats, ovariectomized rats, and ovariectomized rats injected with estradiol or progesterone. Also, adrenocortical alkaline phosphatase activity was determined in groups of rats given different contraceptive pills (lyndiol 2.5, lyndiol 5, gyn-anovlar, eugynon, and ovulen) 1 tablet/rat/day for a period of 2 weeks. No pathological findings were detected in rats given contraceptive pills for 2 weeks, but after 6 weeks of treatment, the animals started to die and definite pathological changes were detected mainly in the liver, spleen, and lungs. It was determined that ovariectomy resulted in a decrease in the activity of the adrenal cortex. Progesterone had no effect, but estradiol injection caused a significant increase in the activity of alkaline phosphatase of the adrenal cortex to values exceeding that of normal females. There was an increase in the activity of the adrenal cortex with any of the pills. The increase was highest with lyndiol 2.5 and lyndiol 5 and least with ovulen. Histological investigation revealed a similarity between the glands subjected to the effects of oral contraceptives and those stimulated by adrenocorticotropic hormone, mainly in the narrowing or even absence of the zona glomerulosa.^ieng
Assuntos
Corticosteroides , Córtex Suprarrenal , Animais de Laboratório , Anticoncepcionais Femininos , Enzimas , Estradiol , Etinilestradiol , Diacetato de Etinodiol , Histologia , Linestrenol , Mestranol , Progesterona , Biologia , Anticoncepção , Anticoncepcionais , Anticoncepcionais Orais , Anticoncepcionais Orais Combinados , Anticoncepcionais Orais Hormonais , Glândulas Endócrinas , Sistema Endócrino , Estrogênios , Serviços de Planejamento Familiar , Hormônios , Noretindrona , Fisiologia , Progestinas , PesquisaAssuntos
Hipopituitarismo/etiologia , Distúrbios Nutricionais/complicações , Schistosoma haematobium , Schistosoma mansoni , Esquistossomose/complicações , 17-Hidroxicorticosteroides/metabolismo , 17-Cetosteroides/metabolismo , Adolescente , Hormônio Adrenocorticotrópico , Alanina Transaminase/metabolismo , Criança , Feminino , Transtornos do Crescimento/diagnóstico , Transtornos do Crescimento/metabolismo , Humanos , Hipopituitarismo/diagnóstico , Hepatopatias/diagnóstico , Hepatopatias/metabolismo , Masculino , Metirapona , Distúrbios Nutricionais/diagnóstico , Distúrbios Nutricionais/metabolismo , Esquistossomose/diagnóstico , Esquistossomose/metabolismo , Testes de Função TireóideaAssuntos
Estriol/urina , Hepatomegalia/complicações , Esquistossomose/sangue , Esquistossomose/urina , 17-Hidroxicorticosteroides/sangue , 17-Cetosteroides/urina , Adulto , Eosinófilos , Histiócitos , Humanos , Fígado/patologia , Cirrose Hepática/sangue , Cirrose Hepática/urina , Linfócitos , Masculino , Pessoa de Meia-Idade , Esquistossomose/complicações , Esquistossomose/patologia , Esplenomegalia/complicaçõesRESUMO
PIP: This Egyptian study made use of ovarian wedge biopsies from 5 patients (aged 30-37, parity greater than 5) undergoing laparotomy. The contraceptives and durations of treatment were Lyndiol 2.5 (2.5 mg lunestrenol, .075 mg mestranol) 3 years; Gynanovlar 21 (3 mg norethisterone acetate, .05 mg ethinyl estradiol) 1 year; Deladroxate monthly injections (150 mg 16, a 17a dihydroxyprogesteorne acetophonid, 10 mcg estadiol enanthate) 1 year; Lyndiol 2.5, 5 years stopped 2 months before operation; and 1 unidentified contraceptive stopped 5 months before operation. except in the 2 cases receiving Lyndiol 2.5, follicular development and maturation had proceeded normally. The tunic a albugenia generally was more thickened than in full-term pregnancy but markedly less thickened than in Stein-Leventhal ovaries. Hyperthecosis was unobserved. Fibrotic and cystic changes were less in extent than in Stein-Leventhal ovaries. Primary damage after long-term therapy appears to be effected at a higher level than the ovary. The authors warn against long-term therapy given freely to young nulliparas and advise interrupted courses (i.e., 1-2 years followed by a periof of rest of 1-2 ovulations) for patients in general.^ieng
Assuntos
Acetofenida de Algestona , Anticoncepcionais Femininos , Etinilestradiol , Histologia , Linestrenol , Mestranol , Ovário , Tempo , Fatores Etários , Biologia , Anticoncepção , Anticoncepcionais , Anticoncepcionais Orais , Anticoncepcionais Orais Combinados , Anticoncepcionais Orais Hormonais , Demografia , Serviços de Planejamento Familiar , Genitália , Genitália Feminina , Injeções , Noretindrona , Paridade , Fisiologia , População , Dinâmica Populacional , Fatores de Tempo , Sistema UrogenitalRESUMO
PIP: Women requesting family planning advice at the Family Planning Clinic at El-Galaa Hospital in Cairo participated in a study investigating some of the main clinicopathological aspects of switching from 1 oral contraceptive to another. The pills were Vestalin M (2.5 mg vinylestrenelone, .1 mg ethinyl estradiol), Vestalin Uno (1 mg vinylestrenelone, .1 mg ethinyl estradiol), Gynovlar (3 mg article says "m" norethisterone acetate, .05 mg ethinyl beta-estradiol), and chlormadinone, .5 mg. Controls used either Vestalin M (68) or Vestalin Uno (55) for 6 months. 24 users of Vestalin M (average 11 months use) switched to Vestalin Uno, thus changing from a higher to lower level of gestagen. 26 users of Vestalin Uno switched to Vestalin M. 3 groups switched from 1 chemical composition to another: 41 Gynovlar users of average 6 months switched to Vestalin Uno, 14 chlormadinone users of average 24 months switched to Vestalin Uno, and 18 chlormadinone users of average 18 months switched to Vestalin M. Post-menstrual endometrial biopsies (cycle days 5-7) were taken before the start of first therapy, before the switch, and at the end of the second drug's trial. Percentages of participants with first-cycle amenorrhea, hypomennorhea, and breakthrough bleeding were 7.5, 3.9, and 9.4 with Vestalin M and 2.0, 8.0, and 2.0 with Vestalin Uno. However, by the fifth cycle, the percentages with hypomennorhea were 25.8 and 12.2, respectively. The high gestagen level reduced the number of endometrial glands and the height of the lining epithelium and caused and excessive decidual reaction of the stroma, a reaction gradually involving the endometrium's compact basal layer, which has no involvement with the luteinization process of the secretory phase in normal women. The material shed included the necks of the endometrial glands responsible for the regeneration of the endometrium in subsequent cycles. When switching from a high to a low gestagen level, the endometrium regenerated and withdrawal bleeding lessened markedly in amount and duration. A few, less systematic, observations are reported for the women changing from 1 chemical composition to another.^ieng
Assuntos
Amenorreia , Anticoncepcionais Orais Combinados , Anticoncepcionais Orais Hormonais , Anticoncepcionais Orais , Endométrio , Histologia , Incidência , Menorragia , Distúrbios Menstruais , Metrorragia , Congêneres da Progesterona , Útero , Biologia , Acetato de Clormadinona , Anticoncepção , Anticoncepcionais , Anticoncepcionais Femininos , Doença , Etinilestradiol , Serviços de Planejamento Familiar , Genitália , Genitália Feminina , Hemorragia , Fisiologia , Pesquisa , Projetos de Pesquisa , Sinais e Sintomas , Sistema UrogenitalRESUMO
PIP: A clinical study of a daily dosage of .5 chlormadinone acetate, a progestagen, was carried out on 101 randomly chosen women for a total of 954 cycles in Galaa Hospital and in the University Hospital Mansoura Faculty of Medicine. There were no reportedly pregnancies. One patient discontinued use after 16 days because of continuous bleeding. There were 20 dropouts between cycles 1-8 with reasons not investigated. Minor side effects included headache, giddiness, nausea, distension and breast discomfort. Of 34 lactating women in the study, 32 reported no effect on lactation and 2 reported diminished lactation. Amenorrhea was reported in 10% of the cycles. Cervicle mucus studies showed the mucus to be hostile to sperm.^ieng