[Clinical and experimental study on the prescription of jianpi yipi].

According to "Spleen-Stomach" theory, the effect of Jianpi Yiqi prescription (JPYQ) was observed clinically and studied experimentally. 168 cases manifested as Spleen-Qi ( ) deficiency including chronic gastritis and peptic ulcer (84 cases), chronic glomerulonephritis (44 cases) and vomitus gravidarum-edema of pregnancy (40 cases) were treated with JPYQ. Estimation were made based on their clinical conditions. Serum gastrin, serum cholyglycine, blood acetylcholine and cholinesterase, blood 5-HT and histamine were measured before and after treatment. The overall effective rate was 92.9% in gastritis and peptic ulcer group, 86.3% in nephritis group and 100% in pregnancy group respectively. A marked increase of serum glycocholic acid level was shown in gastritis and peptic ulcer and vomitus gravidarum groups. That was considered as the result of the secretion of cholic acid by this prescription. Clinical improvement was also obtained in nephritis group accompanying disappearance of albuminuria in 36.4%. Blood level of 5-HT and histamine lowered to some extent and tended to be normal. Besides, this prescription markedly inhibited electric stimulated excitement on isolated longitudinal muscle strip of guinea pig's ileum. The mechanism could be the inhibition of release of acetylcholine from Auerbach's plexus by this prescription.

[Observation on muscular glycogen in spleen-deficient rats treated with a jian pi yi qi decoction].

The relationship between "Spleen" and muscles was explored by determining the amount of muscular glycogen to indicate the stored energy in muscles. The amount of muscular glycogen in normal rats was 6.34 +/- 0.20 mg/g muscles, it was much more than that in Spleen deficiency rats caused by rhubarb (4.27 +/- 0.40 mg/g muscles). In order to observe the effects of Jian Pi Yi Qi decoction on Spleen deficiency, the Spleen deficiency rats were divided into two groups, one of which was treated with Jian Pi Yi Qi decoction as experimental group, the other with distilled water as control. After one week, the amount of muscular glycogen in experimental group was 5.35 +/- 0.16 mg/g muscles and in control 4.63 +/- 0.15 mg/g muscles. It showed that the rising of the amount of muscular glycogen in experimental group was more than that in control with statistic significance but it was still lower than that in normal rats.