Combining aminolaevulinic acid photodynamic therapy with carbon dioxide laser therapy to treat adult-onset laryngeal papillomatosis: case reports and a literature review.

This paper describes 3 cases in which 5-aminolevulinic acid photodynamic therapy (ALA-PDT) was combined with carbon dioxide (CO2) laser therapy to treat patients with adult-onset laryngeal papillomatosis (ALP). Laryngeal papilloma is the most common benign laryngeal tumor, and is usually caused by human papillomavirus (HPV) types 6 and 11. It has the characteristics of rapid growth and frequent recurrence, and has a tendency of malignant transformation. Moreover, it can spread to the lower respiratory tract, which might lead to a rise in mortality risk. Laryngeal papilloma lesions are frequently found on the vocal cords or in the laryngeal cavity, and the characteristic koilocytosis is dispensable in pathological diagnosis of papilloma. Common symptoms include various degrees of hoarseness and wheezing. In the cases reported herein, all 3 patients suffered a recurrence of ALP following treatment. After the removal of the laryngeal papilloma using a combination of ALA-PDT and CO2 laser therapy, the patients were cured; there was no recurrence, and no further malignant transformation was found in the 6-12 months postoperative follow-up period. Our experiences show that ALA-PDT combined with CO2 laser therapy is feasible and effective in the treatment of ALP, and produces no obvious adverse reactions. However, further clinical trials need to be undertaken to confirm the efficacy of this treatment.

Bibliometrics research on radiomics of lung cancer.

BACKGROUND: Lung cancer is currently the most commonly diagnosed malignant tumor worldwide. Exploring ways to improve the accuracy and timeliness of diagnosis has important clinical significance. Radiomics transforms images into high-dimensional data, and uses deep learning and artificial intelligence to improve the accuracy and efficiency of disease diagnosis. There is an increasing amount of research on radiomics in the diagnosis of lung cancer. This study analyzes the relevant literature in the Science Citation Index Expanded (SCI-E) database to understand the current research status and future development direction of lung cancer radiomics. METHODS: This study is based on the SCI-E database. The first search formula is topic = Lung cancer OR Lung neoplasms (#1), the second search formula is topic = Radiomics (#2), and the third search formula is #1 and #2, that is, literature that meets both the first and second search results. CiteSpace software was used to analyze lung cancer radiomics from the annual distribution of articles, countries, institutions, journals, and authors and keywords. HistCite software was used to visualize the citation chronology of the lung cancer radiomics literature, and Pajek software was used to analyze the main path of the citation chronology. RESULTS: There were a total of 749 publications, of which most were original articles (529, 70.63%) and reviews (109, 14.55%). The citation frequency is 21,676 times, the h-index is 66, and the average number of citations per publication is 28.94. The research mainly comes from the United States of America, China and other countries. The research institutions are mainly medical centers such as Moffitt Cancer Center, Maastricht University and Harvard Medical School. The authors are also mainly from these institutions. The literature was published in many related journals, mainly imaging and oncology journals. Keyword analysis shows that in recent years, research has focused on deep learning and artificial intelligence. CONCLUSIONS: The field of lung cancer radiomics is developing rapidly, and the main focuses of research are deep learning and artificial intelligence.

Successful management requiring multidisciplinary cooperation between seven departments for a large right-sided incarcerated traumatic diaphragmatic hernia: a case report and review of literature.

We present a rare case of incarcerated traumatic diaphragmatic hernia (TDH) at the right-side presenting as dramatic dyspnea and acute gastrointestinal obstruction, which required urgent operative repair. This entity is sometimes difficult to ascertain after acute trauma and then consequently give rise to diagnostic delays with life-threatening outcomes. Successful management required a coordinated effort between anesthetist, sonographer, intensive care specialist, thoracic, urological, hepatobiliary and gastrointestinal surgeons. Tight and active multidisciplinary cooperation in this case manifested the positive energy in emergent resuscitation.