RESUMO
Phytochemical investigation of Cydonia oblonga Mill. collected in Xinjiang province, China, led to the isolation and identification of three new dibenzofurans (1-3) along with one known compound (4). Their structures were elucidated based on HRESIMS, spectroscopic data (IR, UV, 1D, 2D NMR) and X-ray diffraction analysis.
Assuntos
Dibenzofuranos/isolamento & purificação , Rosaceae/química , China , Dibenzofuranos/química , Estrutura Molecular , Análise Espectral , Difração de Raios XRESUMO
Phytochemical investigation of the 95% ethanol extract of the whole plant of Palhinhaea cernua afforded five new serratene-type triterpenoids (1-5) together with four known analogues (6-9). The structures of the new compounds were elucidated by extensive spectroscopic analysis and X-ray crystallographic data. Compounds 1-3 triggered apoptosis of Hela-/- cell with EC50 values of 3.49⯱â¯0.05, 0.28⯱â¯0.13 and 7.98⯱â¯0.03⯵M, respectively.
Assuntos
Lycopodiaceae/química , Triterpenos/isolamento & purificação , Apoptose , Cristalografia por Raios X , Células HT29 , Células HeLa , Humanos , Estrutura Molecular , Componentes Aéreos da Planta/químicaRESUMO
Ten terpenoid indole alkaloids, mappiodines A-C and mappiodosides A-G, together with eight known compounds, were isolated from stems of Mappianthus iodoides Hand.-Mazz. Their structures were elucidated by spectroscopic analyses including 1D, 2D NMR, MS and CD methods. The ten compounds were evaluated for their cytotoxic activity, but were inactive.
